Results 61 to 70 of about 16,488,690 (299)

The Relationship between B-cell Epitope and Mimotope Sequences [PDF]

Protein & Peptide Letters, 2016
B-cell epitope is a group of residues which is on the surface of an antigen. It invokes humoral responses. Locating B-cell epitope is important for effective vaccine design, and the development of diagnostic reagents. Mimotope-based B-cell epitope prediction method is a kind of conformational B-cell epitope prediction, and the core idea of the method ...
Zhang, Chunhua, Li, Yunyun, Tang, Weina, Zhou, Zhiguo, Sun, Pingping, Ma, Zhiqiang   +5 more
openaire   +2 more sources

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

In silico Guided Design of a Synthetic Peptide Vaccine Construct from Intrinsically Disordered Regions of the Group Specific Antigen Polyprotein

Biomedical and Biotechnology Research Journal
Background: The group specific antigen (Gag) polyprotein of human immunodeficiency virus-1 is an essential protein for the formation of virus particles and has emerged as a target for potential therapeutic interventions. Identification of viable linear B-
Gwyneth Anne A. Rabanal, Gaitano Arturo Lano III   +1 more
doaj   +1 more source

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus

Journal of Immunology Research, 2017
Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis.
Julio Alonso-Padilla, Esther M. Lafuente, Pedro A. Reche   +2 more
doaj   +1 more source

B-Cell Epitopes in GroEL of Francisella tularensis

PLoS ONE, 2014
The chaperonin protein GroEL, also known as heat shock protein 60 (Hsp60), is a prominent antigen in the human and mouse antibody response to the facultative intracellular bacterium Francisella tularensis (Ft), the causative agent of tularemia. In addition to its presumed cytoplasmic location, FtGroEL has been reported to be a potential component of ...
Zhaohua Lu, Michael J Rynkiewicz, Guillermo Madico, Sheng Li, Chiou-Ying Yang, Hillary M Perkins, Seshi R Sompuram, Vani Kodela, Tong Liu, Timothy Morris, Daphne Wang, Marly I Roche, Barbara A Seaton, Jacqueline Sharon   +13 more
openaire   +4 more sources

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

The Analysis of B-Cell Epitopes of Influenza Virus Hemagglutinin [PDF]

Acta Naturae, 2016
Vaccination has been successfully used to prevent influenza for a long time. Influenza virus hemagglutinin (HA), which induces a humoral immune response in humans and protection against the flu, is the main antigenic component of modern influenza vaccines.
SHCHERBININ D.N., ALEKSEEVA S.V., SHMAROV M.M., SMIRNOV YU.A., NARODITSKIY B.S., GINTSBURG A.L.   +5 more
openaire   +3 more sources

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Phylogenetic Analyses of HPV53 and Prediction of B and T Cell Epitopes

Xiehe Yixue Zazhi
Objective To construct phylogenetic trees based on HPV53 full length sequences, and predict the physical and chemical parameters, secondary structure, B and T cell epitopes of HPV53 proteins(E1, E2, E4, E6, E7, L1, and L2).
LAN Sihan, FENG Min
doaj   +1 more source

In-silico Immunomodelling of SARS-CoV-2 [PDF]

Journal of Medical Microbiology and Infectious Diseases, 2021
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-strand RNA virus belonging to the Coronaviridae family, responsible for coronavirus infectious disease 2019 (COVID-19) with the rapid transmission. This
Amirhosein Maali, Hossein Teimouri, Mehdi Azad, Shahin Amiri, Setare Adibzadeh   +4 more
doaj