Results 151 to 160 of about 65,038 (202)

CD1 expression on B‐CLL lymphocytes

British Journal of Haematology, 1989
Summary In a previous report we showed that D47 CD1a monoclonal antibody positively labelled B‐CLL cells of some patients. Six cases were selected to further characterize CD1 antigenic expression at the leukaemic cell surface using flow cytometry with a battery of six CD1a, two CD1b and two CD1c monoclonal antibodies. CLL cells were positively labelled
H, Merle-Beral, L, Boumsell, A, Michel, P, Debré   +3 more
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New molecular markers in resistant B-CLL

Leukemia & Lymphoma, 2006
B-chronic lymphocytic leukemia (B-CLL) is characterized by a highly variable clinical course which has long remained a stumbling block for clinicians. This variability appears to arise from complex molecular alterations identified in malignant cells from patient subsets.
Julien, Bouley, Ludovic, Deriano, Jozo, Delic, Hélène, Merle-Béral   +3 more
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B-CLL in PLL Transformation Associated with Hypercalcemia

Leukemia & Lymphoma, 1994
A 64-year-old woman is reported with Stage I (Rai) chronic lymphocytic leukaemia (CLL), in whom hypercalcemia developed when an increased proportion of prolymphocytic cells characterized a transformation of CLL in prolymphocytoid leukaemia (CLL/PL). Although hypercalcemia is more frequently found in T-cell leukaemia associated with human T lymphotropic
D, Lerner, C, Esteves, M S, De Oliveira
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Immunophenotype analysis of B‐CLL lymphoma and immunocytoma

APMIS, 1989
The differential diagnosis between lymphocytic lymphoma of the B‐CLL type and immunocytoma (IC) can be difficult when it is based only upon morphological criteria. With the aim of improving the distinction between these subgroups, frozen sections of lymph nodes or other biopsied tissues from 14 cases of B‐CLL and 16 cases of IC were investigated ...
U, Martinsson, C, Sundström, B, Glimelius   +2 more
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B-CLL kicks it up a Notch

Blood, 2009
Mutations in Notch are known to play a critical role in the development of T-ALL.[1][1] In this issue of Blood , Rosati and colleagues provide compelling evidence that Notch signaling also plays an important role in cell survival in B-CLL.
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Comparison of the ZAP70+ and ZAP70− B-CLL Kinome: Higher Kinase Activity in ZAP70+ B-CLL Cells.

Blood, 2006
Abstract B-cell chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease with a highly variable clinical course. The expression of ZAP70 can serve as a novel prognostic marker in B-CLL, but the function of ZAP70 in the disease is still unknown.
Miao Wang, Stephano Rosati, Kaushal Parikh, Maikel Peppelenbosch, Simon Daenen, P.M. Kluin, Lydia Visser   +6 more
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Vaccination Strategies for Patients with B-CLL.

Blood, 2008
Abstract B-chronic lymphocytic leukemia (B-CLL) cells express tumor associated antigens that may generate a T cell mediated immune response, but present these antigens poorly. Moreover, patients with B-CLL often have poor immune function due to the disease or its treatment.
Linhong Li, Madhusudan V Peshwa, Joseph C. Fratantoni, Malcolm K Brenner, Helen E. Heslop, George Carrum, Gianpietro Dotti, Eric Yvon, Fatma V Okur   +8 more
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In vitroActivation of B-CLL Cells

Leukemia & Lymphoma, 1991
Apart from surface Ig receptors, a variety of membrane molecules have now been described to deliver activation and progression signals to human B cells. Among them, CD40 antigen is likely to play a crucial role in the antigen-dependent maturation process. Recent studies performed in the laboratory have established that presentation of anti-CD40 mAbs in
T, Defrance, A C, Fluckiger, J F, Rossi, F, Rousset, J, Banchereau   +4 more
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Immunoglobulin Gene Rearrangement and Expression in B-CLL

Leukemia & Lymphoma, 1991
The malignant cells from most patients with B cell chronic lymphocytic leukemia (B-CLL) and related small lymphocytic lymphomas (SLL) co-express B cell differentiation antigens and the pan-T lymphocytes surface antigen CD5 (Leu 1). As such, B-CLL and related lymphomas generally may be considered malignancies of the CD5 B cell, a minor B cell ...
T J, Kipps, L Z, Rassenti, S, Duffy, R, Kobayashi, T, Martin, P P, Chen, D A, Carson   +6 more
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Chromosomal abnormalities in B-CLL.

Nouvelle revue francaise d'hematologie, 1989
Amongst 141 patients with B-CLL, 53% had an abnormal karyotype. Treatment free survival was shorter in those with karyotypic abnormalities, and especially in those with multiple abnormalities. Multiple abnormalities tended to be associated with progressive disease. Trisomy 12 alone carried no worse a prognosis than a normal karyotype.
D G, Oscier, M, Fitchett, T J, Hamblin
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