Results 111 to 120 of about 1,274,301 (280)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Unification of G-Metric, Partial Metric, and b-Metric Spaces
Abstract and Applied Analysis, 2014 Using the concepts of G-metric, partial metric, and b-metric spaces, we define a new concept of generalized partial b-metric space. Topological and structural properties of the new space are investigated and certain fixed point theorems for contractive ...
Nawab Hussain +3 more
doaj +1 more source
STUDY ABOUT CYCLIC MAP ON PARTIAL b – METRIC SPACES AND FIXED-POINT THEOREM
Tikrit Journal of Pure Science, 2018 In this paper, we study the existence and uniqueness of fixed point of cyclic map α-admissible on partial b – metric ...
Muayyad Mahmood Khalil
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Controlled Metric Type Spaces and the Related Contraction Principle
Mathematics, 2018 In this article, we introduce a new extension of b-metric spaces, called controlled metric type spaces, by employing a control function α ( x , y ) of the right-hand side of the b-triangle inequality.
Nabil Mlaiki +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Two-dimensional conformal sigma models and exact string solutions
, 1993 We discuss two classes of exact (in $\a'$) string solutions described by conformal sigma models. They can be viewed as two possibilities of constructing a conformal model out of the non-conformal one based on the metric of a $D$-dimensional homogeneous ...
Tseytlin, A. A.
core +1 more source