Novel approach of vaccination against Brucella abortus 544 based on a combination of fusion proteins, human serum albumin and brucella abortus Lipopolysaccharides. [PDF]
, 2010 Lipopolysaccharide (LPS) of Brucella abortus is an essential component for developing the subunit vaccine against brucellosis. B. abortus LPS was extracted by n-butanol, purified by ultracentrifugation and detoxified by alkaline treatment.
Abdulamir, Ahmed Sahib +8 more
core +1 more source
Brucella and Osteoarticular Cell Activation: Partners in Crime [PDF]
, 2017 Osteoarticular brucellosis is the most common presentation of human active disease although its prevalence varies widely. The three most common forms of osteoarticular involvement are sacroiliitis, spondylitis, and peripheral arthritis.
Adamopoulos +95 more
core +1 more source
Frontiers in Endocrinology, 2020 Brucellosis is a prevalent global zoonotic infection but has far more impact in developing countries. The adipocytes are the most abundant cell type of adipose tissue and their secreted factors play an important role in several aspects of the innate and ...
Ayelén Ivana Pesce Viglietti +3 more
doaj +1 more source
Investigation of the Proportion of Brucella abortus and Brucella melitensis in Sheep and Goat Milk
Veterinary Medicine International, 2023 Despite the implementation of brucellosis eradication programs in Iran, this disease is still endemic and highly prevalent among ruminants in this country.
Saeid Rostami +3 more
doaj +1 more source
Lipopolysaccharide (LPS) from Brucella abortus is less toxic than that from Escherichia coli, suggesting the possible use of B. abortus or LPS from B. abortus as a carrier in vaccines [PDF]
Infection and Immunity, 1992 Brucella abortus may be useful as a component of vaccines. This is because it possesses several unique properties as a carrier that enable it to stimulate human B cells even in the relative absence of T cells. Human immunodeficiency virus type 1 proteins conjugated to B.
J, Goldstein +8 more
openaire +2 more sources
Frontiers in Microbiology, 2020 Brucella abortus is a pathogen that survives in macrophages. Several virulence factors participate in this process, including the open reading frame (ORF) BAB1_0270 codifying for a zinc-dependent metalloproteinase (ZnMP).
Leonardo A. Gómez +7 more
doaj +1 more source
Comprehensive Identification of Immunodominant Proteins of Brucella abortus and Brucella melitensis Using Antibodies in the Sera from Naturally Infected Hosts [PDF]
, 2016 Brucellosis is a debilitating zoonotic disease that affects humans and animals. The diagnosis of brucellosis is challenging, as accurate species level identification is not possible with any of the currently available serology-based diagnostic methods ...
Eravci, Murat +7 more
core +2 more sources
Neutrophils as Trojan Horse Vehicles for Brucella abortus Macrophage Infection
Frontiers in Immunology, 2019 Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B.
Cristina Gutiérrez-Jiménez +6 more
doaj +1 more source
Brucella abortusRB51 Induces Protection in Mice Orally Infected with the Virulent StrainB. abortus2308 [PDF]
Infection and Immunity, 2003 ABSTRACTBrucellae are gram-negative, facultative intracellular bacteria which are one of the most common causes of abortion in animals. In addition, they are the source of a severe zoonosis. In this trial, we evaluated the effect of oral inoculation ofBrucella abortusRB51 in mice against a challenge infection withB. abortus2308. First, we showed that a
Paolo, Pasquali +4 more
openaire +2 more sources
The aggregation of Brucella abortus occurs under microaerobic conditions and promotes desiccation tolerance and biofilm formation [PDF]
, 2012 Brucella abortus causes brucellosis mainly in cattle. The infection is transmitted to humans by ingestion of animal products or direct contact with infected material.
Almiron, Marta A. +2 more
core +1 more source