Results 61 to 70 of about 600,274 (298)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Lived experiences of stressors and problems of higher education students on teacher education course in the Eastern Highlands of Zimbabwe, 2019

The Pan African Medical Journal, 2020
INTRODUCTION: There is increasing levels of stressors and hardship among higher education students especially in low and middle income countries. Higher education institutions have an important role to play in the provision of robust and comprehensive ...
Mathew Nyashanu, Rebecca Nuwematsiko, Wendy Nyashanu, Dung Ezekiel Jidong   +3 more
doaj   +1 more source

Comparison of direct and perturbation approaches to analysis of infinite–dimensional feedback control systems

International Journal of Applied Mathematics and Computer Science, 2021
For general boundary control systems in factor form some necessary and sufficient conditions for generation of an analytic exponentially stable semigroup are proposed in both direct and perturbation forms for comparison. The direct approach is applicable
Grabowski Piotr
doaj   +1 more source

SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation.

Cell Reports, 2017
The inhalation of silica dust is associated with fibrosis and lung cancer, which are triggered by macrophage inflammatory responses; however, how macrophages recognize silica remains largely unknown. Here, we identify by functional expression cloning the
Misato Tsugita, N. Morimoto, M. Tashiro, K. Kinoshita, Masafumi Nakayama   +4 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Optimization of bike-sharing repositioning operations: A reactive real-time approach

EURO Journal on Transportation and Logistics
One of the critical issues in the operation of vehicle-sharing systems is the optimization of the fleet repositioning movements. Repositioning implies the artificial movement of vehicles from places where they accumulate to others in which they are ...
Enrique Jiménez-Meroño, Francesc Soriguera   +1 more
doaj   +1 more source

Prevention of Escherichia coli infection in broiler chickens with Lactobacillus plantarum B1

Poultry Science, 2017
&NA; Two studies were performed to assess the efficacy of Lactobacillus plantarum B1 in prevention of pathogenic Escherichia coli K88 gastrointestinal infection in broilers. In an in vitro study, L.
S. Wang, Q. Peng, H. Jia, X. F. Zeng, J. Zhu, C. Hou, X. Liu, Fan Yang, S. Qiao   +8 more
semanticscholar   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Identification of Rubber Belt Damages Using Machine Learning Algorithms

Applied Sciences
This paper presents the experimental results of a Machine Learning application for the health monitoring of a conveyor belt. The real-time analysis of the rubber belt condition is a crucial issue in achieving safety and avoiding critical failures and ...
Miroslaw Rucki, Arturas Kilikevicius, Damian Bzinkowski, Tomasz Ryba   +3 more
doaj   +1 more source

Robust perfluorophenylboronic acid-catalyzed stereoselective synthesis of 2,3-unsaturated O-, C-, N- and S-linked glycosides

Beilstein Journal of Organic Chemistry, 2019
A convenient protocol was developed for the synthesis of 2,3-unsaturated C-, O-, N- and S-linked glycosides (enosides) using 20 mol % perflurophenylboronic acid catalyst via Ferrier rearrangement.
Madhu Babu Tatina, Xia Mengxin, Rao Peilin, Zaher M. A. Judeh   +3 more
doaj   +1 more source