Results 171 to 180 of about 1,188,690 (195)

Obesity Induced by High Fat Diet Attenuates Postinfarct Myocardial Remodeling and Dysfunction in Adult B6D2F1 Mice

Journal of Molecular and Cellular Cardiology, 2015
Obesity is a major risk factor for cardiovascular morbidity and mortality. However, some studies suggest that among patients with established cardiovascular disease, obesity is associated with better prognosis, a phenomenon described as the obesity paradox.
Javier Inserte, Jordi Bañeras, Rafael Simó   +2 more
exaly   +3 more sources

More on the circadian melatonin rhythm in pineals from domesticated B6D2F1 mice.

Chronobiologia, 1987
For melatonin (a chronomodulator of adrenal cortical function, immune phenomena and carcinogenesis), a circadian rhythm is demonstrated in aqueous pineal homogenate of domesticated B6D2F1 mice. Domestication as such does not eliminate a mechanism of cephalo-adrenal coordination.
G M, Brown, S, Sánchez de la Peña, N, Marques, L J, Grota, F, Ungar, F, Halberg   +5 more
openaire   +1 more source

Distribution of cisplatin in tumor-free versus tumor-bearing B6D2F1 mice.

Archiv fur Geschwulstforschung, 1990
In healthy as well as in leukemia P388- or melanoma B16-bearing B6D2F1 mice the platinum concentrations in liver, serum and kidneys were determined after i.v. administration of 10 mg/kg cisplatin. In a tumor stage related to about 40% of the mean survival time (MST) no differences in platinum distribution between tumor-bearing and healthy animals could
R, Amlacher, V, Böckel, A, Mackowiak, M, Stadeler, D, Frankenberg, H, Hoffmann   +5 more
openaire   +1 more source

Age-dependent effects of a chronic ultramild stress procedure on open-field behaviour in B6D2F1 female mice

Physiology & Behavior, 2000
Few studies have been devoted to the interaction between age and stress. However, in view of the age-related changes in various components of the stress responses, the effects of stress may not be constant with age. In this study, we used a dimensional approach to compare open-field behaviour of B6D2F1 female mice, aged 5-6, 11-12, 17-18 and 23-24 ...
M, Pardon, F, Pérez-Diaz, C, Joubert, C, Cohen-Salmon   +3 more
openaire   +2 more sources

Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation

Carcinogenesis, 1995
Logistic regression analysis of age-specific prevalences for neoplastic and non-neoplastic liver lesions was used to examine treatment responses for B6C3F1 and B6D2F1 male mice continuously exposed to chlordane (55 p.p.m.) and to determine whether neoplasms were dependent on continuous exposure in the B6C3F1 mice.
D E, Malarkey, T R, Devereux, G E, Dinse, P C, Mann, R R, Maronpot   +4 more
openaire   +2 more sources

Neither non-contact exposure nor mating affect serum LH and FSH in male B6D2F1 house mice

Physiology & Behavior, 1979
Abstract Sexually experienced male B6D2F1 mice were allowed to copulate until ejaculation (equivalent to time 0) and then bled at subsequent times (0, 15, 60 min) after ejaculation. In another portion of the experiment sexually experienced males of the same strain were separated from estrous females by a double-walled hardware cloth and permitted 40 ...
D M, Quadagno, T E, McGill, S M, Yellon, B D, Goldman   +3 more
openaire   +2 more sources

Influence of leukemia P388 on plasma concentration-time profiles of bendamustine in B6D2F1 mice.

Die Pharmazie, 1992
It was the aim of this study to investigate whether leukemia P388 being an important murine transplantation tumor may alter the plasma concentration-time profiles of the alkylating antineoplastic agent bendamustine (1) in mice. In an advanced tumor stage the rapid decline of 1 plasma levels was found to be retarded in tumor-bearing in comparison to ...
R, Amlacher, H, Weber, R, Preiss, H, Hoffmann   +3 more
openaire   +1 more source

Influence of age on antileukemic action, subacute toxicity and tissue distribution of ambazone in B6D2F1 mice.

Archiv fur Geschwulstforschung, 1990
The influence of age of experimental animals on the antileukemic activity, toxicity and distribution of ambazone, a new potential antineoplastic agent, was studied in 2- and 12-month-old B6D2F1 mice. The predominant effect observed was a significant reduction of the antileukemic action of this compound in old-aged mice.
R, Amlacher, J, Baumgart, A, Härtl, H, Weber, H J, Kühnel, W, Schulze, H, Hoffmann   +6 more
openaire   +1 more source

A single dose of granulocyte colony-stimulating factor modifies radiation-induced death in B6D2F1 mice.

Experimental hematology, 1993
Granulocyte colony stimulating factor (G-CSF) stimulates the proliferation of progenitor cells committed to myeloid differentiation. In animal models, G-CSF is able to stimulate granulocyte recovery and promote survival after lethal or sublethal irradiation when administered as daily injections, suggesting an influence on the residual hematopoietic ...
A, Sureda, A, Valls, E, Kadar, M, Algara, J, Inglés-Esteve, A, Bigas, M, Jaume, M, Lacruz, L M, Tobajas, M, Rutllant   +9 more
openaire   +1 more source

Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.

Anticancer research, 2001
The expression of retinoid receptors is altered during the development of several types of cancer. In the present study, we determined the influence of high dietary concentrations of 4-hydroxyphenylretinamide (4-HPR) and 13-cis-retinoic acid (13-cis-RA) on RAR-beta mRNA expression in female mice. Expression of liver and lung RAR-beta RNA increased with
G L, Johanning, M B, Cope, T, Wilborn, C J, Grubbs, R A, Lubet   +4 more
openaire   +1 more source