Results 1 to 10 of about 828 (107)

The Morphology of Inner Cell Mass Is the Strongest Predictor of Live Birth After a Frozen-Thawed Single Embryo Transfer

Frontiers in Endocrinology, 2021
BackgroundThe scoring system for human blastocysts is traditionally based on morphology; however, there are controversies on the effect of morphology parameters on pregnancy outcomes.
Jihui Ai, Lei Jin, Yu Zheng, Peiwen Yang, Bo Huang, Xiyuan Dong   +5 more
doaj   +3 more sources

Beyond the Inner Cell Mass: Evaluating the Impact of Inner Cell Mass Visibility on Implantation Prediction in Static Blastocyst Images – A Retrospective Cohort Study

Journal of Human Reproductive Sciences
Background: Embryo selection in IVF often relies on inner cell mass (ICM) morphology as a predictor of implantation. However, in static two-dimensional images, ICM visibility may be limited by technical factors like orientation or focus, rather than ...
Doel Bose Pande, Hemant Deshmukh, Sandeep Kumar Verma, Gajendra Singh Tomar   +3 more
doaj   +7 more sources

Cell Lineage Allocation Within the Inner Cell Mass of the Mouse Blastocyst [PDF]

Results and Problems in Cell Differentiation, 2012
At the time of implantation, the early mouse embryo consists of three distinct cell lineages: the epiblast (EPI), primitive endoderm (PrE), and trophectoderm (TE). Here we will focus on the EPI and PrE cell lineages, which arise within the inner cell mass (ICM) of the blastocyst.
Anna-Katerina Hadjantonakis, Panagiotis Xenopoulos, Minjung Kang   +2 more
exaly   +3 more sources

Entropy sorting of single-cell RNA sequencing data reveals the inner cell mass in the human pre-implantation embryo

Stem Cell Reports, 2023
Summary: A major challenge in single-cell gene expression analysis is to discern meaningful cellular heterogeneity from technical or biological noise. To address this challenge, we present entropy sorting (ES), a mathematical framework that distinguishes
Arthur Radley, Elena Corujo-Simon, Jennifer Nichols, Austin Smith, Sara-Jane Dunn   +4 more
doaj   +3 more sources

Nr5a2 ensures inner cell mass formation in mouse blastocyst

Cell Reports
Summary: Recent studies have elucidated Nr5a2’s role in activating zygotic genes during early mouse embryonic development. Subsequent research, however, reveals that Nr5a2 is not critical for zygotic genome activation but is vital for the gene program ...
Yanhua Zhao, Meiting Zhang, Jiqiang Liu, Xinglin Hu, Yuchen Sun, Xingwei Huang, Jingyu Li, Lei Lei   +7 more
doaj   +3 more sources

Trophectoderm, Inner Cell Mass, and Expansion Status for Live Birth Prediction After Frozen Blastocyst Transfer: The Winner Is Trophectoderm

Life
Despite advancements in technologies such as time-lapse microscopy and artificial intelligence, the gold standard for embryo selection still relies on standard morphological assessment. Several studies have investigated the correlation between blastocyst
Alessandro Bartolacci, Sofia de Girolamo, Lisett Solano Narduche, Elisa Rabellotti, Lucia De Santis, Enrico Papaleo, Luca Pagliardini   +6 more
doaj   +3 more sources

Beyond the Inner Cell Mass: Evaluating the Impact of Inner Cell Mass Visibility on Implantation Prediction in Static Blastocyst Images

Journal of Human Reproductive Sciences
Doel Bose Pande, Hemant Deshmukh, Sandeep Kumar Verma, Gajendra Singh Tomar   +3 more
doaj   +4 more sources

A Haspin promoter element induces tissue-specific methylation of a transcription region and the regulation of gene expression in mouse ova [PDF]

Cell Journal, 2022
HASPIN is a nuclear serine-threonine kinase originally identified in the mouse testis. Its 193 bp DNA promoter element(hereafter, 193PE) regulates bidirectional, synchronous gene expression in the germ cells of male mice.
Hiromitsu Tanaka, Keizo Tokuhiro
doaj   +1 more source

Morphology of inner cell mass: a better predictive biomarker of blastocyst viability [PDF]

PeerJ, 2022
Background Transfer of embryos at the blastocyst stage is one of the best approaches for achieving a higher success rate in In vitro fertilization (IVF) treatment as it demonstrates an improved uterine and embryonic synchrony at implantation.
Sargunadevi Sivanantham, Mahalakshmi Saravanan, Nidhi Sharma, Jayashree Shrinivasan, Ramesh Raja   +4 more
doaj   +2 more sources

Mosaicism in the inner cell mass of human blastocysts [PDF]

Human Reproduction, 1998
Although mosaicism was shown to be a normal feature in cleaving embryos, its consequences for the late preimplantation stages are unknown. We performed blastocyst immunosurgery, followed by fluorescent in-situ hybridization (FISH), to determine the number of cells and degree of mosaicism in the inner cell mass (ICM) of human blastocysts.
S, Evsikov, Y, Verlinsky
openaire   +2 more sources