Trophectoderm, Inner Cell Mass, and Expansion Status for Live Birth Prediction After Frozen Blastocyst Transfer: The Winner Is Trophectoderm [PDF]
LifeDespite advancements in technologies such as time-lapse microscopy and artificial intelligence, the gold standard for embryo selection still relies on standard morphological assessment. Several studies have investigated the correlation between blastocyst
Alessandro Bartolacci +6 more
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Beyond the Inner Cell Mass: Evaluating the Impact of Inner Cell Mass Visibility on Implantation Prediction in Static Blastocyst Images – A Retrospective Cohort Study [PDF]
Journal of Human Reproductive SciencesBackground: Embryo selection in IVF often relies on inner cell mass (ICM) morphology as a predictor of implantation. However, in static two-dimensional images, ICM visibility may be limited by technical factors like orientation or focus, rather than ...
Doel Bose Pande +3 more
doaj +9 more sources
Entropy sorting of single-cell RNA sequencing data reveals the inner cell mass in the human pre-implantation embryo [PDF]
Stem Cell Reports, 2023 Summary: A major challenge in single-cell gene expression analysis is to discern meaningful cellular heterogeneity from technical or biological noise. To address this challenge, we present entropy sorting (ES), a mathematical framework that distinguishes
Arthur Radley +4 more
doaj +4 more sources
Beyond the Inner Cell Mass: Evaluating the Impact of Inner Cell Mass Visibility on Implantation Prediction in Static Blastocyst Images [PDF]
Journal of Human Reproductive SciencesDoel Bose Pande +3 more
doaj +5 more sources
Nr5a2 ensures inner cell mass formation in mouse blastocyst
Cell ReportsSummary: Recent studies have elucidated Nr5a2’s role in activating zygotic genes during early mouse embryonic development. Subsequent research, however, reveals that Nr5a2 is not critical for zygotic genome activation but is vital for the gene program ...
Yanhua Zhao +7 more
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Morphology of inner cell mass: a better predictive biomarker of blastocyst viability [PDF]
PeerJ, 2022 Background Transfer of embryos at the blastocyst stage is one of the best approaches for achieving a higher success rate in In vitro fertilization (IVF) treatment as it demonstrates an improved uterine and embryonic synchrony at implantation.
Sargunadevi Sivanantham +4 more
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The Morphology of Inner Cell Mass Is the Strongest Predictor of Live Birth After a Frozen-Thawed Single Embryo Transfer [PDF]
Frontiers in Endocrinology, 2021 BackgroundThe scoring system for human blastocysts is traditionally based on morphology; however, there are controversies on the effect of morphology parameters on pregnancy outcomes.
Jihui Ai +5 more
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Characterizing Inner Pressure and Stiffness of Trophoblast and Inner Cell Mass of Blastocysts. [PDF]
Biophys J, 2018 It has long been recognized that mechanical forces underlie mammalian embryonic shape changes. Before gastrulation, the blastocyst embryo undergoes significant shape changes, namely, the blastocyst cavity emerges and expands, and the inner cell mass (ICM) forms and changes in shape.
Wang X +5 more
europepmc +5 more sources
Glutamine transport by mouse inner cell masses [PDF]
Reproduction, 1995 Abstract Mouse blastocysts take up glutamine by specific transport systems. Glutamine is an important precursor for macromolecular synthesis and a potential alternative fuel to glucose. This study compared glutamine uptake in blastocysts and isolated inner cell masses and characterized the major participating systems in the latter ...
Jamshidi M.B., Kaye P.L.
openaire +5 more sources
Double Zona Drilling for Trophectoderm Biopsy: A Safe Strategy When Inner Cell Mass Herniates [PDF]
DiagnosticsBackground/Objectives: Laser-assisted zona pellucida (ZP) drilling on day 4 embryos is routinely performed in IVF laboratories to facilitate trophectoderm (TE) herniation for blastocyst biopsy.
En-Hui Cheng +9 more
doaj +2 more sources