A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 [PDF]
, 2018 CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic ...
Alarcon, Balbino +13 more
core +5 more sources
Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. [PDF]
, 1993 Cognate interactions between antigen-presenting B and T cells play crucial roles in immunologic responses. T cells that have been activated via the crosslinking of CD3 are able to induce B cell proliferation and immunoglobulin secretion in a major ...
Kipps, TJ, Ranheim, EA
core
Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]
, 2014 Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin +9 more
core +2 more sources
Advanced Science, EarlyView.BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou +9 more
wiley +1 more source
Suppression of Human T-Cell Responses to β-Cells by Activation of B7-H4 Pathway
Cell Transplantation, 2006 B7-H4, a recently described member of the B7 family of cosignal molecules, is thought to be involved in the regulation of cellular and humoral immune responses through receptors on activated T and B cells. Human islet cells express positive B7-H4 mRNA in
Dawei Ou +7 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Journal of Translational MedicineBackground Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing global incidence. Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to ...
Punchita Rujirachaivej +10 more
doaj +1 more source
Prevention of CD8 T Cell Deletion during Chronic Viral Infection
Viruses, 2021 During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physically
David G. Brooks +3 more
doaj +1 more source
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. [PDF]
, 1995 Insulin-dependent diabetes mellitus (IDDM) is thought to be an immunologically mediated disease resulting in the complete destruction of the insulin-producing islets of Langerhans.
Bluestone, JA +7 more
core
Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]
, 2008 B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M. +9 more
core +1 more source