Results 131 to 140 of about 343,349 (228)

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

Immunology, Volume 177, Issue 2, Page 317-328, February 2026.
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta, Shi‐Chuen Miaw, Tse‐Ching Chen, Chia‐Shiang Chang, Yu‐Lin Huang, Yung‐Chang Lin, Chun‐Yen Lin, Ching‐Tai Huang   +7 more
wiley   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction

Proceedings of the National Academy of Sciences of the United States of America, 2016
R. Levy, Ziv Rotfogel, D. Hillman, Andrey Popugailo, G. Arad, Emmanuelle Supper, F. Osman, R. Kaempfer   +7 more
semanticscholar   +1 more source

HLA Class II Alleles Are Associated With Anti‐Drug Antibodies in Ulcerative Colitis Patients Treated With Etrolizumab

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT Patients treated with etrolizumab, a monoclonal antibody drug for ulcerative colitis, often develop anti‐drug antibodies (ADA) and neutralising antibodies (NAb). To investigate genetic risk factors, we evaluated associations between HLA alleles and ADA/NAb development. HLA‐DQB1*06:03 demonstrated the most significant association with both ADA (
Ashis Saha, Mark I. McCarthy, Saloumeh K. Fischer, Gizette Sperinde, Christian Hammer   +4 more
wiley   +1 more source

Immunity and immunosuppression in experimental visceral leishmaniasis

Brazilian Journal of Medical and Biological Research, 2004
Leishmaniasis is a disease caused by protozoa of the genus Leishmania, and visceral leishmaniasis is a form in which the inner organs are affected. Since knowledge about immunity in experimental visceral leishmaniasis is poor, we present here a review on
Goto H., Lindoso J.A.L.
doaj  

Expression and immmunogenicity of HLA-B27 in high-transfection recipient P815: [PDF]

, 1989
Kuon, W., Riethmüller, Gert, Thureau, S. R., Weiss, Elisabeth H., Wildner, G.   +4 more
core   +1 more source

Organization, sequence and expression of the HLA-B27 gene [PDF]

, 1985
Doerner, C., Kuon, W., Lang, M., Riethmüller, Gert, Weiss, Elisabeth H.   +4 more
core   +1 more source

B7-H3 and GD2 overexpression as immunotherapeutic targets in retinoblastoma. [PDF]

Sci Rep
Sujjitjoon J, Ng WL, Kongkla K, Jarutatsanangkoon K, Chongsutakawewong K, Subhadhirasakul S, Uiprasertkul M, Udompunturak S, Junking M, Yenchitsomanus PT, Atchaneeyasakul LO.   +10 more
europepmc   +1 more source

Three-Dimensional Tumor Spheroids Reveal B7-H3 CAR T Cell Infiltration Dynamics and Microenvironment-Induced Functional Reprogramming in Solid Tumors. [PDF]

Cells
Chen F, Ning K, Xie Y, Yang X, Yu L, Wang X.   +5 more
europepmc   +1 more source

c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors. [PDF]

Cell Rep Med
Balke-Want H, Keerthi V, Del Carmen Arenas M, Chen Y, Malipatlolla M, Klysz DD, Xu P, Ho K, Asano K, Stahl D, Huang J, Retherford A, Patel S, Fowler C, Maas L, Gkitsas-Long N, Jiang Q, Liu X, Ullrich R, George J, Heitzeneder S, Tunuguntla R, Sage J, Sotillo E, Mackall CL, Feldman SA.   +25 more
europepmc   +1 more source