Results 171 to 180 of about 4,559,918 (199)
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The International Journal of Biochemistry & Cell Biology, 2005
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other ...
Juha, Ollila, Mauno, Vihinen
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B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other ...
Juha, Ollila, Mauno, Vihinen
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CD5 B cells and B-cell malignancies
Current Opinion in Hematology, 1999Over the past year, progress has been made in understanding of the physiology and disease associations of CD5+ (B1) B cells, although their exact role in pathogenesis remains unclear. Earlier studies on the negative function of CD5 within the B-cell receptor complex have been substantiated, and it seems likely that soon the signaling pathways used by ...
Andrew P. Jewell +3 more
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Lupus, 2002
This session had as its central theme the analysis of peptide epitopes and their relationship with lupus pathogenesis. New information on the role of peptides opens up the possibility of treatments based on inducing immunological tolerance although care needs to be taken since it is diffi cult to predict flare or remission of disease after exposure to
Michael R. Ehrenstein, Bevra H. Hahn
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This session had as its central theme the analysis of peptide epitopes and their relationship with lupus pathogenesis. New information on the role of peptides opens up the possibility of treatments based on inducing immunological tolerance although care needs to be taken since it is diffi cult to predict flare or remission of disease after exposure to
Michael R. Ehrenstein, Bevra H. Hahn
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Somatic Cell Genetics, 1977
Hybrid cells were prepared by fusin an immunoglobulin-secreting mouse myeloma lin e (B cell) with an allogenic T-cell lymphoma which expresses the surface antigen Thy 1. The resulting hybrids expressed H2 antigens of both parental cells and secreted the immunoblobulin of the myeloma parent but did not express the Thy 1 antigen of the lymphoma parent ...
Kohler, G, Pearson, T, Milstein, C
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Hybrid cells were prepared by fusin an immunoglobulin-secreting mouse myeloma lin e (B cell) with an allogenic T-cell lymphoma which expresses the surface antigen Thy 1. The resulting hybrids expressed H2 antigens of both parental cells and secreted the immunoblobulin of the myeloma parent but did not express the Thy 1 antigen of the lymphoma parent ...
Kohler, G, Pearson, T, Milstein, C
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FOXO in B-cell lymphopoiesis and B cell neoplasia
Seminars in Cancer Biology, 2018FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors.
Thomas Wirth, Alexey Ushmorov
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2017
γδ T cells constitute the third arm of a tripartite adaptive immune system in jawed vertebrates, besides αβ T cells and B cells. Like the other two lymphocyte-types, they express diverse antigen receptors, capable of specific ligand recognition. Functionally, γδ T cells represent a system of differentiated subsets, sometimes engaged in cross-regulation,
Hua Huang +5 more
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γδ T cells constitute the third arm of a tripartite adaptive immune system in jawed vertebrates, besides αβ T cells and B cells. Like the other two lymphocyte-types, they express diverse antigen receptors, capable of specific ligand recognition. Functionally, γδ T cells represent a system of differentiated subsets, sometimes engaged in cross-regulation,
Hua Huang +5 more
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Nature Reviews Immunology, 2004
The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of
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The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of
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Noncanonical B Cells: Characteristics of Uncharacteristic B Cells
The Journal of Immunology, 2023Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
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Regulation of B-cell commitment to plasma cells or to memory B cells
Seminars in Immunology, 1997During humoral immune responses, B-lymphocyte activation is followed by differentiation along either the plasma cell pathway or the memory B-cell pathway. Recent studies suggest that CD40-CD40 ligand, OX-OX40 ligand, a group of cytokines and intracellular transcriptional factors may all contribute to B-lymphocyte differentiation control.
Yong-Jun Liu, Jacques Banchereau
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