Results 31 to 40 of about 31,066,857 (388)

MicroRNAs in B cell development and malignancy [PDF]

, 2012
MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and ...
Fernando, Thilini R., Rao, Dinesh S., Rodriguez-Malave, Norma I.   +2 more
core   +4 more sources

CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma

New England Journal of Medicine, 2002
Background The standard treatment for patients with diffuse large-B-cell lymphoma is cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Rituximab, a chimeric monoclonal antibody against the CD20 B-cell antigen, has therapeutic activity in
B. E. C. Oiffier, E. R. L. Epage, J. Rière, R. A. H. Erbrecht, T. Illy, R. E. B. Ouabdallah, P. Ierre, M. Orel, E. R. V. A. D. E. N. Este, G. I. S. Alles, P. H. G. Aulard, F. E. R. Eyes, C. H. G. Isselbrecht   +12 more
semanticscholar   +2 more sources

Opposing roles of B lymphocyte subsets in atherosclerosis

Autoimmunity, 2017
Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on ...
Tin Kyaw, Peter Tipping, Alex Bobik, Ban-Hock Toh   +3 more
doaj   +1 more source

Hypoxia and B cells

Experimental Cell Research, 2017
The ability of cells to sense and adapt to changes in oxygen is mediated by hypoxia-inducible factor (HIF). Immune cells function in physiologically complex and varying environments whereby oxygen, pH, nutrients, metabolites and cytokines are continuously fluctuating.
Burrows, N, Maxwell, PH
openaire   +4 more sources

B cells in autoimmunity [PDF]

Arthritis Research & Therapy, 2009
B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development
Thomas Dörner, Peter E. Lipsky, A.M. Jacobi   +2 more
openaire   +3 more sources

BCL-W has a fundamental role in B cell survival and lymphomagenesis. [PDF]

, 2017
Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival.
Annette S. Kim, Barrett, Christine M. Eischen, Clare M. Adams, Gibson, Haldar, Jerald Z. Gong, John K. Choi, Lee, Placzek, Ramkrishna Mitra, Schmitz, Visco, Wang, Yang   +14 more
core   +2 more sources

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFκB activity in vertebrate B-cells [PDF]

, 2007
To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A ...
Andrew M. Scharenberg, Arnold, Chiu, Dequiedt, Doppler, Doreen A. Cantrell, Ferns, Genot, Guha, Iglesias, Jackson, Marklund, Matthews, Matthews, Matthews, Matthews, Matthews, Mihailovic, Nishikawa, Parra, Ping Liu, Rey, Rey, Rey, Sharon A. Matthews, Shinohara, Sinnett-Smith, Sinnett-Smith, Sommer, Song, Stokoe, Storz, Storz, Storz, Storz, Storz, Sturany, Trauzold, Vega, Waldron, Wang, Wang, Wong, Wong, Wood, Zhukova   +45 more
core   +3 more sources

Unique B cell responses in B cell-dependent and B cell-independent EAE

Autoimmunity, 2011
Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Kamaldeen A. Muili, Guorong Liu, Vrushali V. Agashe, Jeri-Anne Lyons   +3 more
openaire   +2 more sources

Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. [PDF]

, 2018
The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown ...
Bernard, Claude CA, Brück, Wolfgang, Feldmann, Linda, Häusler, Darius, Häusser-Kinzel, Silke, Lehmann-Horn, Klaus, Lepennetier, Gildas, Torke, Sebastian, Weber, Martin S, Zamvil, Scott S   +9 more
core   +1 more source

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Brocker, Thomas, Hubele, S., Lane, P., Lanzavecchia, A., McConnell, F., Padovan, E.   +5 more
core   +1 more source