Results 51 to 60 of about 9,288,310 (309)

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies

EMBO Molecular Medicine, 2023
Human monoclonal antibodies (mAbs) against the central repeat and junction domain of Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to guide malaria vaccine design compared to antibodies against the PfCSP C terminus.
Opeyemi Ernest Oludada, Giulia Costa, Clare Burn Aschner, Anna S Obraztsova, Katherine Prieto, Caterina Canetta, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmüller, Rajagopal Murugan, Jean‐Philippe Julien, Elena A Levashina, Hedda Wardemann   +12 more
doaj   +1 more source

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
core   +1 more source

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Effects of Exogenous Proteins Injection into the Bursa of Fabricius on Humoral Immunity in Neonatal Chickens

The Journal of Poultry Science, 2012
Early researches have shown that the bursa of Fabricius is a critical organ for development of B lymphocytes in birds. Exogenous proteins from the gut lumen or the environment are taken up by the follicle-associated epithelium and enter into the bursal ...
Fang Yuan, Guojin Wu, Junshuang Gao, Xiaoyan Tang, Zandong Li   +4 more
doaj   +1 more source

CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]

, 2019
The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad, DiRusso, Christopher J., Gilmore, Thomas D., Kagermazova, Larisa, Liu, Yuekun, McCaslin, Ethan Z., Miyamoto, Shigeki, Wuerzberger-Davis, Shelly M., Yeo, Alan T.   +8 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Advancements in understanding the regulatory mechanism of B-cell immune activation associated with adenotonsillar hypertrophy

生物医学转化
B cells play a crucial role in recognizing external antigens through their surface B cell receptor (BCR), essential for generating protective antibodies and immune memory.
Chen Wenjing, Gao Ruiyu, Huang Jingwen, Ye Jingying, Liu Wanli   +4 more
doaj   +1 more source

Sources of Antifungal Drugs

Journal of Fungi, 2023
Due to their eukaryotic heritage, the differences between a fungal pathogen’s molecular makeup and its human host are small. Therefore, the discovery and subsequent development of novel antifungal drugs are extremely challenging.
Giel Vanreppelen, Jurgen Wuyts, Patrick Van Dijck, Paul Vandecruys   +3 more
doaj   +1 more source

Tfg (Trk fused gene) is a Carma-1/IKKgamma interacting protein involved in CD40-induced canonical NF-KB signaling [PDF]

, 2009
Carma-1 is required for B cell receptor-/CD40- and T cell receptor-/CD28-induced B- and T-cell activation via JNK and NF-betaB. In B cells, Carma-1 becomes phosphorylated by PKCbeta, leading to its oligomerization.
Grohmann, Marcus, Hampel, Martin, Hermann, Ingo, Jäck, Hans-Martin, Kalbacher, Hubert, Karas, Michael (Prof. Dr.), Mielenz, Dirk   +6 more
core   +1 more source