Results 231 to 240 of about 216,975 (333)

Modification of the rapid antimicrobial susceptibility testing from blood culture protocol for a resource-limited setting. [PDF]

open access: yesJAC Antimicrob Resist
Imwattana K   +5 more
europepmc   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

open access: yesChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet   +7 more
wiley   +1 more source

Ligand Screening and Discovery Using Cocktail Soaking and Automated Microcrystal Electron Diffraction

open access: yesChemMedChem, Volume 20, Issue 12, June 17, 2025.
Cocktail soaking using single‐crystal X‐ray diffraction allows high‐throughput crystallographic ligand screening against protein targets. However, protein microcrystals are not amenable to this approach. Herein, a workflow integrating cocktail soaking with automated microcrystal electron diffraction to allow rapid ligand screening, structure ...
Jieye Lin   +3 more
wiley   +1 more source

Performance of Xpert MTB/RIF and acid-fast bacilli smear microscopy for the diagnosis of pulmonary tuberculosis using bronchoalveolar lavage samples in negative or sputum-scarce adults in Colombia: a retrospective diagnostic accuracy study. [PDF]

open access: yesBMC Infect Dis
Sabella-Jiménez V   +9 more
europepmc   +1 more source

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