Results 211 to 220 of about 692,677 (291)

Exploring the Impact of Phenanthroline‐based Glycoconjugated Ru(II) Polypyridyl Photosensitizers on Metastasis‐related Processes”

open access: yesChemistry – A European Journal, Accepted Article.
Novel water‐soluble, phosphorescent ruthenium(II) polypyridyl‐glycoconjugates of general formula [Ru{N‐(1,10‐phenanthroline)}2{N‐(1,10‐phenanthrolin‐5‐yl)‐β‐glycopyranosylamine}][Cl]2 (glycopyranosyl = D‐glucopyranosyl (1), D‐mannopyranosyl (2), L‐rhamnopyranosyl (3), L‐xylopyranosyl (4) and 2,3,4‐tri‐O‐acetyl‐L‐xylopyranosyl (5)) and corresponding ...
Elena de la Torre-Rubio   +5 more
wiley   +1 more source

From Desferrioxamine B Umpolung to an Enantiopure Bifunctional Chelator for 89Zr‐immunoPET

open access: yesChemistry – A European Journal, EarlyView.
Functional group transformations were performed at the pendent amine residue of desferrioxamine B (DFO), the commercial siderophore used in various medical applications, including iron decorporation, antibiotic development, and molecular imaging.
Laurie Zujew   +2 more
wiley   +1 more source

Corn cob pyrolysis: A systematic literature review of methods and applications

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Mapping the research landscape of corn cob pyrolysis. Abstractas The agricultural sector is experiencing a surge in waste generation due to population growth, creating an urgent need to convert byproducts into value‐added products. Maize (Zea mays L.), a leading global crop, produces significant byproducts, such as corn cob, which are often undervalued.
Vilmar Steffen   +5 more
wiley   +1 more source

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

open access: yesCytoskeleton, EarlyView.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar   +3 more
wiley   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

open access: yesChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri   +6 more
wiley   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

open access: yesChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet   +7 more
wiley   +1 more source

Molecular identification of the strains contained in commercial products for improving agriculture in Africa [PDF]

open access: yes, 2010
Atieno, Mary   +3 more
core  

Ligand Screening and Discovery Using Cocktail Soaking and Automated Microcrystal Electron Diffraction

open access: yesChemMedChem, EarlyView.
Cocktail soaking using single‐crystal X‐ray diffraction allows high‐throughput crystallographic ligand screening against protein targets. However, protein microcrystals are not amenable to this approach. Herein, a workflow integrating cocktail soaking with automated microcrystal electron diffraction to allow rapid ligand screening, structure ...
Jieye Lin   +3 more
wiley   +1 more source

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