Results 111 to 120 of about 281,344 (286)

Pediatric ALL Treatment Modifications in Low- and Middle-Income Countries: A Systematic Review

JCO Global Oncology
PURPOSEFor children with ALL in low- and middle-income countries (LMICs), treatment regimen adaptation based on local contexts is often necessary. However, the clinical impact of such modifications is poorly understood.
Caitlyn Duffy, Savannah Allen, Thomas B. Alexander, Eden C. Andrew, Manoo Bhakta, Nancy S. Bolous, Miguel Bonilla, Lisa M. Force, Catherine Habashy, Jeremy Hassan, Cody McMillan, Michael J. McNeil, Marta Salek, Tonya Ureda, Ruth Wang'ondu, Becky Wing-Yan Yuen, Meenakshi Devidas, Heather M. Brandt, Michelle L. Hermiston, Nickhill Bhakta   +19 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays

Arthritis Research & Therapy
Background Autoantibodies targeting antigens carrying distinct post-translational modifications (PTMs), including citrullinated, carbamylated, and acetylated residues, are characteristic for rheumatoid arthritis (RA).
Roxane Biersteker, Aegli Athanasiadou, Stef van der Meulen, Tineke J. van Wesemael, Linda M. Slot, Theresa Kissel, René E. M. Toes, Leendert A. Trouw, Diane van der Woude   +8 more
doaj   +1 more source

Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

Journal of Nucleic Acids, 2011
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations
Matthew J. Crawford, Srinivas Rapireddy, Raman Bahal, Iulia Sacui, Danith H. Ly   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Repatterning of mammalian backbone regionalization in cetaceans

Nature Communications
Cetacean reinvasion of the aquatic realm is an iconic ecological transition that led to drastic modifications of the mammalian body plan, especially in the axial skeleton. Relative to the vertebral column of other mammals that is subdivided into numerous
Amandine Gillet, Katrina E. Jones, Stephanie E. Pierce   +2 more
doaj   +1 more source

CancerSeg-XA: Enhanced Breast Cancer Histo-pathology Segmentation Using Xception Backbone with Attention Mechanisms

Journal of Communications Software and Systems
Breast cancer remains a formidable health challenge requiring advanced computational tools for accurate diagnosis and treatment planning. This study hypothesizes that modifica-tions to the DeepLabV3+ architecture, such as incorporating an attention layer
Alaa Mohamed Youssef, Wessam Hassan El Behaidy, Aliaa Abdel-Haleim Abdel-Razik Youssif   +2 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Backbone Modifications of HLA-A2-Restricted Antigens Induce Diverse Binding and T Cell Activation Outcomes. [PDF]

J Am Chem Soc, 2021
Gibadullin R, Randall CJ, Sidney J, Sette A, Gellman SH.   +4 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source