Results 81 to 90 of about 7,532,055 (283)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Interactions between background matching and disruptive colouration: Experiments using human predators and virtual crabs

, 2015
Interactions between disruptive colouration and the match between prey and background spot size were manipulated in two experiments that used time taken by human 'predators' to find artificial prey (virtual crab morphs) against heterogeneous backgrounds ...
P. Todd, Huijia Phua, K. Toh
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Host defense triggers rapid adaptive radiation in experimentally evolving parasites

Evolution Letters, 2019
Adaptive radiation occurs when the members of a single lineage evolve different adaptive forms in response to selection imposed by competitors or predators.
Sarah E. Bush, Scott M. Villa, Juan C. Altuna, Kevin P. Johnson, Michael D. Shapiro, Dale H. Clayton   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Gloger's Rule or Historical Conjecture? Tests in Mammals

Ecology and Evolution
Gloger's rule states that homeotherms are darker at lower latitudes; however, a number of 19th‐century naturalists also suggested that animals are more brightly coloured in the tropics than in temperate regions. Using phylogenetic comparative methods, we
Natasha Howell, Tim Caro
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Camouflage Using Surface Disruption: The Importance of Corners Versus Edges

Ecology and Evolution
Disruptive colouration is a common mode of camouflage used by predators and prey to conceal their body contours. However, it is unclear how disruptive colouration hinders the detection and recognition of three‐dimensional (3D) body shapes.
Ruby McLellan, Vanessa K. Bowden, Troy A. W. Visser, Jennifer L. Kelley   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Geographical Variation of Colour Change in the Arabian Killifish (Aphaniops dispar Sensu Lato) From Freshwater and Marine Ecosystems

Ecology and Evolution
Widely distributed animals may exhibit substantial plastic physiological, morphological and behavioural responses to environmental changes. One such extraordinary form of plasticity is colour change, which varies substantially among most taxonomic groups.
Ateah Alfakih, Nicola J. Nadeau, Penelope J. Watt   +2 more
doaj   +1 more source