Results 91 to 100 of about 21,556 (197)

Baclofen in alcohol use disorder: mechanisms, efficacy and clinical applications

Alcohol use disorder (AUD) is a significant global health concern, contributing to millions of deaths and various health complications including liver disease or cardiovascular issues.
Izabella Ewa Pura
core   +1 more source

Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen

, 2017
Oral baclofen has long been a mainstay in the management of spasticity. This review looks at the clinical evidence for the efficacy and safety of oral baclofen in patients with spasticity of any origin or severity, to determine whether there is a ...
Ertzgaard, Per,, A Calabrese, C Campo, Campo, Claudia,, Calabrese, Alessandra,, P Ertzgaard   +5 more
core   +1 more source

The role and uptake of drug and alcohol services in patients with alcohol‐associated acute pancreatitis at a large multisite health service

Internal Medicine Journal, EarlyView.
Abstract Background Alcohol consumption remains an independent risk factor for recurrent presentations of alcohol‐associated acute pancreatitis (AAP). Although there are recognised guidelines for alcohol use disorder (AUD), there are no recommendations on targeting alcohol cessation to reduce recurrence of AAP in guidelines for acute pancreatitis ...
Cindy Ho, Hardesh Dhillon, Alexander Mitropoulos, Eliza Flanagan, Timothy Phan, Joshua Haron Abasszade, Jeremy Tse, Bowen Xia, Kyle Williams, Faris Gondal, Sally Jane Bell, David Jacka, Simon Hew   +12 more
wiley   +1 more source

Chronic Baclofen Abuse and Withdrawal Delirium

, 2011
Baclofen is a GABA-B agonist used for muscle spasticity in disorders such as multiple sclerosis. It has growing applications in the treatment of alcohol dependence [1] and its role in the treatment in other addiction disorders has recently been explored [
Nasti, Julian J., Vlasios Brakoulias, Brakoulias, Vlasios (R19651), Julian J. Nasti   +3 more
core   +1 more source

Intrathecal Baclofen Infusion Pumps in the Treatment of Spasticity: A Retrospective Cohort Study in a Portuguese Centre

Acta Médica Portuguesa, 2019
Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from ...
Pedro Videira Reis, Catarina Rocha Vieira, Ana Cristina Midões, Virginia Rebelo, Paula Barbosa, Armanda Gomes   +5 more
doaj   +1 more source

Safety Challenges of Using High Dose Baclofen for Alcohol Use Disorder: A Focused Review

Frontiers in Psychiatry, 2018
Since the early 2000s, the gamma-aminobutyric acid type B (GABA-B) receptor agonist baclofen has been extensively used for treating alcohol use disorder (AUD).
Benjamin Rolland, Benjamin Rolland, Nicolas Simon, Nicolas Franchitto   +3 more
doaj   +1 more source

Baclofen zur Behandlung der Alkoholabhängigkeit

, 2010
Fragestellung: Ziel dieser Arbeit ist die zusammenfassende Darstellung des aktuellen Kenntnisstandes zur Behandlung der Alkoholabhängigkeit mit Baclofen unter Berücksichtigung präklinischer und klinischer Befunde.
Christian A. Müller, Jakob Hein, Katharina Volkmar, Andreas Heinz   +3 more
core   +1 more source

Serum Baclofen Concentrations in Four Dogs With Baclofen Toxicosis Treated With In‐Series Carbon Hemoperfusion and Hemodialysis

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To report serum baclofen concentrations before, during, and after in‐series carbon hemoperfusion (cHP) and hemodialysis (HD) in four dogs with severe baclofen toxicosis. Series Summary This series involves four dogs with serum samples collected before, during, and after in‐series cHP/HD.
Amanda Spillane, Jiwoong Her, Nahvid Etedali, Joanna Finstad, Catherine Langston   +4 more
wiley   +1 more source

Baclofen for alcohol withdrawal.

, 2017
Review question: This review attempted to evaluate the efficacy and safety of baclofen as a therapy for alcohol withdrawal syndrome (AWS) in people with alcoholism.
Liu, Jia, Wang, Lunig
core   +1 more source

A randomized, open-label, standard controlled, parallel group study of efficacy and safety of baclofen, and chlordiazepoxide in uncomplicated alcohol withdrawal syndrome

Biomedical Journal, 2016
Background: Alcohol withdrawal syndrome (AWS) is a distressing condition, generally controlled by benzodiazepines (BZD's). Baclofen, a gamma-aminobutyric acid-B (GABAB) agonist, has also shown promising results in controlling AWS.
K. Girish, K. Vikram Reddy, Lakshmi V. Pandit, H.P. Pundarikaksha, R. Vijendra, K. Vasundara, R. Manjunatha, Moulya Nagraj, R. Shruthi   +8 more
doaj   +1 more source