Results 81 to 90 of about 5,400 (175)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review

, 2013
Jessica L Brennan,2 Jonathan G Leung,1 Jane P Gagliardi,3 Sarah K Rivelli,3 Andrew J Muzyk4 1Department of Hospital Pharmacy Services, Mayo Clinic, Rochester, MN, 2Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center ...
Rivelli SK, Muzyk AJ, Brennan JL, Leung JG, Gagliardi JP   +4 more
core  

Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen

, 2017
Oral baclofen has long been a mainstay in the management of spasticity. This review looks at the clinical evidence for the efficacy and safety of oral baclofen in patients with spasticity of any origin or severity, to determine whether there is a ...
Ertzgaard, Per,, A Calabrese, C Campo, Campo, Claudia,, Calabrese, Alessandra,, P Ertzgaard   +5 more
core   +1 more source

A rare case report of baclofen induced mania: Uncovering the unexpected

Telangana Journal of Psychiatry
Baclofen is one of the most commonly used anti-craving agents; the effect is mainly mediated by antagonizing GABA-B receptors, thereby reducing the craving for alcohol.
Barath Ramanathan, Souganya Vijayan, Arun Selvaraj, Mirdula Devi   +3 more
doaj   +1 more source

Safety strategies for everyday community physical activity by adults with cerebral palsy and high support needs: A qualitative case series

Developmental Medicine &Child Neurology, EarlyView.
Safety strategies used by adults with complex forms of cerebral palsy when participating in community‐based physical activity were explored in this study. Physical assistance was the main safety strategy in use, provided for four key purposes. The attributes of support people in community settings was key to experiences of safety.
Georgia B McKenzie, Stacey L Cleary, Freya E Munzel, Carlee Holmes, Prue E Morgan, Iain M Dutia, Nora Shields   +6 more
wiley   +1 more source

Baclofen for narcolepsy with cataplexy: two cases

, 2015
Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa, 2Royal Ottawa Mental Health Center, Ottawa, ON, Canada Abstract: Narcolepsy is a disabling sleep ...
Lee EK, Douglass AB
core  

Baclofen in alcohol use disorder: mechanisms, efficacy and clinical applications

Alcohol use disorder (AUD) is a significant global health concern, contributing to millions of deaths and various health complications including liver disease or cardiovascular issues.
Izabella Ewa Pura
core   +1 more source

TREATMENT Dose-Response Effect of Baclofen in Reducing Daily Alcohol Intake in Alcohol Dependence: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial

, 2020
-Aims: To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence.
Giorgio Bedogni, Lorenzo Leggio, Fabio Caputo, Raffaele Landolfi, Giovanni Gasbarrini, Giovanni Addolorato, Silvia Cardone, Anna Ferrulli, Baclofen Study Group   +8 more
core  

Baclofen zur Behandlung der Alkoholabhängigkeit

, 2010
Fragestellung: Ziel dieser Arbeit ist die zusammenfassende Darstellung des aktuellen Kenntnisstandes zur Behandlung der Alkoholabhängigkeit mit Baclofen unter Berücksichtigung präklinischer und klinischer Befunde.
Christian A. Müller, Jakob Hein, Katharina Volkmar, Andreas Heinz   +3 more
core   +1 more source

Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report

BMC Nephrology, 2018
Background Baclofen is a centrally acting GABAB receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function
Emad Khazneh, Alaa Shamlawi, Kamel Jebrin, Zakaria Hamdan, Osama Sawalmeh   +4 more
doaj   +1 more source