Results 71 to 80 of about 15,483 (191)
Safety Challenges of Using High Dose Baclofen for Alcohol Use Disorder: A Focused Review
Frontiers in Psychiatry, 2018 Since the early 2000s, the gamma-aminobutyric acid type B (GABA-B) receptor agonist baclofen has been extensively used for treating alcohol use disorder (AUD).
Benjamin Rolland +3 more
doaj +1 more source
Acta Médica Portuguesa, 2019 Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from ...
Pedro Videira Reis +5 more
doaj +1 more source
Effects of online motor cortex transcranial ultrasound stimulation on interhemispheric inhibition
The Journal of Physiology, EarlyView.Abstract figure legend The present study investigated the online effect of primary motor cortex (M1) transcranial ultrasound stimulation (TUS) on interhemispheric inhibition (IHI) from the sonicated M1 to the contralateral M1 and on the contralateral M1 excitability.
Yanqiu Wang +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
Orthopedic surgery in children with intrathecal baclofen pumps
Journal of Pediatric Rehabilitation Medicine, 2013 AIMS: Children with cerebral palsy often have severe spasticity leading to deformity that requires multiple orthopedic surgeries. Intrathecal baclofen pump implantation effectively decreases severe spasticity. The objective of this study was to determine
Judith L. Gooch +2 more
doaj +1 more source
Biomedical Journal, 2016 Background: Alcohol withdrawal syndrome (AWS) is a distressing condition, generally controlled by benzodiazepines (BZD's). Baclofen, a gamma-aminobutyric acid-B (GABAB) agonist, has also shown promising results in controlling AWS.
K. Girish +8 more
doaj +1 more source
The Six Pillars of Lifestyle Medicine in MASLD: An Evidence‐Based Guide
Liver International Communications, Volume 7, Issue 3, September 2026.ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and is projected to affect more than 40% of adults by 2050. Although pharmacologic therapies are emerging, lifestyle modification remains the foundation of management.
Jigyasa Sharma, Kathleen Viveiros
wiley +1 more source
Sleep Research, Volume 3, Issue 3, Page 286-291, September 2026.Abstract A 41‐year‐old male patient presented with a 13‐year history of recurrent nocturnal penile pain associated with erections during sleep. Over the course of his illness, the patient attended outpatient clinics on 298 occasions and was hospitalized three times. The primary symptom reported was erectile pain occurring during sleep.
Liping Zhang +5 more
wiley +1 more source
The oscillatory response of the electroretinogram and neuronal adaptation
Acta Ophthalmologica, Volume 104, Issue 6, Page 616-637, September 2026.Abstract After more than 50 years, there still remains a challenge and an interest to know more as well as extend and deepen our understanding of the small rapid wavelets, the oscillatory potentials (OPs), of the electroretinogram (ERG) and the neuronal adaptation of the retina.
Lillemor Wachtmeister, Anders Eklund
wiley +1 more source
Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1702-1710, August 2026.ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source