Results 71 to 80 of about 21,556 (197)

Baclofen, (how) does it work?: The efficacy and working mechanism of high-dose baclofen in the treatment of alcohol dependence [PDF]

, 2018
In this PhD project the efficacy and the working mechanism of high-dose baclofen for the treatment of alcohol use disorder (AUD) were examined. We conducted a randomized controlled trial (RCT) with a high-dose baclofen group (150 mg/day), a low-dose ...
Beraha Menahem, E.M.
core   +12 more sources

Severe, Protracted Spasm of Urinary Bladder and Autonomic Dysreflexia Caused by Changing the Suprapubic Catheter in a Cervical Spinal Cord Injury Patient: Treatment by a Bolus Dose and Increased Total Daily Dose of Intrathecal Baclofen

Clinical Medicine Insights: Case Reports, 2016
Background Intrathecal administration of baclofen by implanted pump reduces rigidity and muscle spasms. Its use specifically to control bladder spasms has not been reported.
Subramanian Vaidyanathan, Tun Oo, Bakul M. Soni, Peter L. Hughes, Gurpreet Singh   +4 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Evaluation of an innovative, green, and eco-friendly baclofen-loaded niosome (Baclosome) formulation for pain management by transdermal delivery [PDF]

Nanomedicine Journal
Objective(s): Baclofen, a muscle relaxant, exhibits limited dermal penetration, restricting its therapeutic efficacy. This study aimed to optimize baclofen delivery using ultrasonically manufactured niosomes (Baclosomes) for improved antinociceptive and ...
Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Seyede Nastaran Mousavi, Seyyed Mohammad Hassan Hashemi, Seyyed Mobin Rahimnia   +5 more
doaj   +1 more source

Expanding the Phenotype of PARK‐PRKN to Spastic Paraplegia: A Report of Two Cases

Movement Disorders Clinical Practice, EarlyView.
Nicolas Geoffre, Thomas Ollivier, Guillaume Baille, Luc Defebvre, Vincent Huin, Eugenie Mutez   +5 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Pneumomediastinum: A case report of baclofen toxicity

, 2023
Introduction: Baclofen is a γ -aminobutyric acid (GABA) agonist used to treat spasticity; however, it may be toxic at dosages above 200 mg. The psychological, nervous, cardiovascular, gastrointestinal, musculoskeletal, and respiratory systems are all ...
Babak Alavi Farzaneh, Zari Meidani, Fatemeh, Rahmati, Rahem, Mojdeh Ghorbankhani, Vahid Reisi-Vanani, Alavi Farzaneh, Babak, Rahem Rahmati, Ghorbankhani, Mojdeh, Fatemeh Zari Meidani, Reisi-Vanani, Vahid   +9 more
core   +1 more source

Safety strategies for everyday community physical activity by adults with cerebral palsy and high support needs: A qualitative case series

Developmental Medicine &Child Neurology, EarlyView.
Safety strategies used by adults with complex forms of cerebral palsy when participating in community‐based physical activity were explored in this study. Physical assistance was the main safety strategy in use, provided for four key purposes. The attributes of support people in community settings was key to experiences of safety.
Georgia B McKenzie, Stacey L Cleary, Freya E Munzel, Carlee Holmes, Prue E Morgan, Iain M Dutia, Nora Shields   +6 more
wiley   +1 more source

Intervention outcomes of children with non‐degenerative dystonia and associated hyperkinetic movement disorders: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify the outcomes reported in published studies of intervention approaches used with non‐degenerative childhood hyperkinetic movement disorders, including dystonia, dyskinesia, hypertonia, athetosis, chorea, cerebral palsy, involuntary movement, and kernicterus, and map them to the International Classification of Functioning ...
Hortensia Gimeno, Hannah Scott, Rocio Muñoz Sanchez, Alice Doohan, Deepti Chugh, Adrienne Harvey, Kirsty Stewart, Peter Rosenbaum, Grace Stynes, Khamani Edwards, Katherine Knighting   +10 more
wiley   +1 more source

Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study

Developmental Medicine &Child Neurology, EarlyView.
Children with cerebral palsy who experienced clinically significant sleep disturbances, their parents, and their siblings, were interviewed to understand the impact of sleep disturbance on the whole family. Six themes were identified, demonstrating the need for tailored, multidisciplinary, holistic sleep assessment and intervention, and family support.
Mary‐Elaine McCavert, Oliver Perra, Karen McConnell, Claire Kerr   +3 more
wiley   +1 more source