Results 61 to 70 of about 5,400 (175)

Pneumomediastinum: A case report of baclofen toxicity

, 2023
Introduction: Baclofen is a γ -aminobutyric acid (GABA) agonist used to treat spasticity; however, it may be toxic at dosages above 200 mg. The psychological, nervous, cardiovascular, gastrointestinal, musculoskeletal, and respiratory systems are all ...
Babak Alavi Farzaneh, Zari Meidani, Fatemeh, Rahmati, Rahem, Mojdeh Ghorbankhani, Vahid Reisi-Vanani, Alavi Farzaneh, Babak, Rahem Rahmati, Ghorbankhani, Mojdeh, Fatemeh Zari Meidani, Reisi-Vanani, Vahid   +9 more
core   +1 more source

Severe Case of Oral Baclofen Withdrawal Resulting in Mechanical Ventilation

Journal of Investigative Medicine High Impact Case Reports, 2022
Abrupt baclofen withdrawal may be life-threatening with varied neuropsychiatric manifestations. We present a case of baclofen withdrawal necessitating intubation.
Resha Khanal, Sharad Oli, Janet Chan Gomez, Sahar Tahir, Binita Bhandari, Saketram Komanduri   +5 more
doaj   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Central sleep apnea caused by low dosage of baclofen: a case report

Journal of Medical Case Reports
Background Baclofen can relax muscle spasticity by inhibiting the transmission of both mono- and polysynaptic reflexes at the spinal cord. It has been increasingly used off-label for the management of spinal cord lesions or neurologic disorders. However,
Xiaoqiong Luo, Qidi Ding, Yanan Liu, Fang Han, Chenyu Li, Xiaosong Dong   +5 more
doaj   +1 more source

Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats

Indian Journal of Endocrinology and Metabolism
Introduction: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani   +3 more
doaj   +1 more source

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C., Pepeu, G., Gratzl, M., Gamel-Didelon, Katia, Jung, H., Mayerhofer, Artur   +5 more
core   +1 more source

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Frontiers in Psychiatry, 2018
Background: The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist, may reduce alcohol consumption, craving and promote abstinence.
Claire F. Durant, Louise M. Paterson, Sam Turton, Susan J. Wilson, James F. M. Myers, Suresh Muthukumaraswamy, Ashwin Venkataraman, Inge Mick, Susan Paterson, Tessa Jones, Limon K. Nahar, Rosa E. Cordero, David J. Nutt, Anne Lingford-Hughes   +13 more
doaj   +1 more source

Baclofen-induced neurotoxicity in a dialysis patient managed with continuous venovenous hemodialysis: A case report and literature review

Turkish Journal of Emergency Medicine
Despite documented cases of baclofen toxicity in individuals with kidney disease, the drug is widely prescribed for various medical conditions, primarily spasticity, hiccups, and multiple sclerosis.
Nejah F. Ellouze, Darpanarayan Hazra, Suad Al Abri   +2 more
doaj   +1 more source

Baclofen overdose: A curious case of medical sales representative

Clinical Case Reports, 2022
In this case report, a medical sales representative consumed 250 mg of Baclofen out of curiosity. Baclofen has life‐threatening complications like seizures, respiratory depression, and coma.
Swotantra Gautam, Aakash Neupane, Mandita Chamlagain, Sandip Pokhrel, Durga Neupane, Rochana Acharya, Sagar Panthi   +6 more
doaj   +1 more source