Results 41 to 50 of about 21,556 (197)

Baclofen Intoxication

, 2015
Baclofen is a β-(ρ-chlorophenyl) derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is usually prescribed for spasticity of spinal cord origin, intractable hiccup, trigeminal neuralgia, hemifacial spasm, and tardive dyskinesia.
İlkin Çankayalı, Karaca, Iclal, Demirag, Kubilay, İclal Karaca, Cankayali, Ilkin, Karakoc, Ozge, Uyar, Mehmet, Bor, Canan, Mehmet Uyar, Özge Karakoç, Kubilay Demirağ, Canan Bor   +11 more
core   +1 more source

Systemic and intrathecal baclofen produce bladder antinociception in rats

BMC Urology, 2021
Background Baclofen, a clinically available GABAB receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception.
Timothy J. Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand   +4 more
doaj   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Neonatal baclofen withdrawal following intrauterine exposure

Journal of Pediatric Rehabilitation Medicine, 2022
BACKGROUND: Pregnant women with spinal cord injuries are often advised to continue oral baclofen during pregnancy to manage spasticity, though the potential for adverse events in neonates is not well understood.
Marianne A. Mousigian, Sara A. Rosenblum, Erin E. Neil Knierbein, Alecia K. Daunter   +3 more
doaj   +1 more source

Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Letícia Hamm‐Buiar, Daniela Gorski, Marcela Harumi Kagueiama, Astrid Wiens   +3 more
wiley   +1 more source

Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia

, 2013
Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders. The effects of baclofen on voluntary motor output are limited and not yet understood.
Bunday, K.L., Perez, M.A., Chen, R., Barry, M.D.   +3 more
core   +1 more source

Baclofen for alcohol use disorder. [PDF]

, 2023
Authors' conclusions: Baclofen likely reduces the risk of relapse to any drinking and increases the percentage of abstinent days, mainly among detoxified participants.
Silvia Minozzi, Roberta Agabio, Rosner, Susanne, Agabio R, Susanne Rösner, Minozzi S, Minozzi, Silvia, Saulle R, Agabio, Roberta, Rosella Saulle, Rösner S, Saulle, Rosella   +11 more
core   +1 more source

Effects of the GABA(B) agonist baclofen on volitional swallowing in normal subjects

Kaohsiung Journal of Medical Sciences, 2023
The GABA(B) receptor agonist baclofen is known to suppress the rate of spontaneous swallowing but not pharyngeal muscle contraction. The extent to which baclofen may alter volitional swallowing is not currently known.
Jui‐Sheng Hung, Shu‐Wei Liang, Taher Omari, Ming‐Wun Wong, Wei‐Yi Lei, Chih‐Hsun Yi, Tso‐Tsai Liu, Lin Lin, Chien‐Lin Chen   +8 more
doaj   +1 more source

Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells

Journal of Ovarian Research, 2020
Objective This study aimed to explore the effects of activating GABAB1 receptor by baclofen on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of ovarian cancer cells.
Jun Gao, Yao Gao, Shixin Lin, Xia Zou, Yukai Zhu, Xintong Chen, Hong Wan, Hong Zhu   +7 more
doaj   +1 more source

Solubility of baclofen in 1-hexyl-4-methylpyridinium bromide + water binary mixtures [PDF]

شیمی کاربردی روز, 2017
In this paper, solubility of baclofen was studied by gravimetric method. The solubility of baclofen was measured in (water + 1-hexyl-4-methylpyridinium bromide) binary mixtures from 293.1 K to 313.1 K under atmosphere pressure.
Abbas Mehrdad, Sahar Ehsani-Tabar, Sara Taeb   +2 more
doaj   +1 more source