Results 41 to 50 of about 5,400 (175)

Baclofen Intoxication

, 2015
Baclofen is a β-(ρ-chlorophenyl) derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is usually prescribed for spasticity of spinal cord origin, intractable hiccup, trigeminal neuralgia, hemifacial spasm, and tardive dyskinesia.
İlkin Çankayalı, Karaca, Iclal, Demirag, Kubilay, İclal Karaca, Cankayali, Ilkin, Karakoc, Ozge, Uyar, Mehmet, Bor, Canan, Mehmet Uyar, Özge Karakoç, Kubilay Demirağ, Canan Bor   +11 more
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia

, 2013
Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders. The effects of baclofen on voluntary motor output are limited and not yet understood.
Bunday, K.L., Perez, M.A., Chen, R., Barry, M.D.   +3 more
core   +1 more source

Solubility of baclofen in 1-hexyl-4-methylpyridinium bromide + water binary mixtures [PDF]

شیمی کاربردی روز, 2017
In this paper, solubility of baclofen was studied by gravimetric method. The solubility of baclofen was measured in (water + 1-hexyl-4-methylpyridinium bromide) binary mixtures from 293.1 K to 313.1 K under atmosphere pressure.
Abbas Mehrdad, Sahar Ehsani-Tabar, Sara Taeb   +2 more
doaj   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan, Stefan Brugger, Martina Kurejova, Tegeder Imgard, Gangadharan Vijayan, Imgard Tegeder, Gangadharan, Vijayan, Tegeder, Irmgard, Kuner Rohini, Kurejova, Martina, Rohini Kuner, Kurejova Martina, Nitin Agarwal, Bernhard Bettler, Brugger Stefan, Vijayan Gangadharan, Tegeder, Imgard, Agarwal, Nitin, Bettler Bernhard, Bettler, Bernhard, Agarwal Nitin, Kuner, Rohini   +21 more
core   +1 more source

Baclofen overdose treated with continuous venovenous hemofiltration [PDF]

, 2015
Purpose: Overdose with baclofen, a derivative of the inhibitory neurotransmitter γ-aminobutyric acid, may lead to severe respiratory and central nervous system depression and can be life-threatening.
Meulendijks, Didier, Koks, Cornelis H W, Schellens, Jan H M, Huitema, Alwin D R, Pharmacoepidemiology and Clinical Pharmacology, Beijnen, Jos H., Sub Clinical Pharmacology, Khan, Saheed   +7 more
core   +1 more source

An unusual case of baclofen abuse

Indian Journal of Psychological Medicine, 2016
Baclofen was initially used for the treatment of spastic conditions. Last decade has seen its emergence as a treatment of profound interest in alcohol dependence, opiates and cocaine abuse, and tobacco addiction.
Soumitra Das, Dhanya Sasidharan Palappalllil, Sumesh Thoppil Purushothaman, Varun Rajan   +3 more
doaj   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Effects of the GABA(B) agonist baclofen on volitional swallowing in normal subjects

Kaohsiung Journal of Medical Sciences, 2023
The GABA(B) receptor agonist baclofen is known to suppress the rate of spontaneous swallowing but not pharyngeal muscle contraction. The extent to which baclofen may alter volitional swallowing is not currently known.
Jui‐Sheng Hung, Shu‐Wei Liang, Taher Omari, Ming‐Wun Wong, Wei‐Yi Lei, Chih‐Hsun Yi, Tso‐Tsai Liu, Lin Lin, Chien‐Lin Chen   +8 more
doaj   +1 more source