Results 31 to 40 of about 5,400 (175)

Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat

Frontiers in Physiology, 2021
Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown.
Wendy L. Olsen, Melanie Rose, Frank J. Golder, Cheng Wang, Julie C. Hammond, Donald C. Bolser   +5 more
doaj   +1 more source

Speaking fluently with baclofen? [PDF]

, 2017
Baclofen is a new and promising pharmacological compound for the treatment of alcohol dependence (AD). Although several randomised trials found a reduction of craving and higher abstinence rates with low and high doses of baclofen, others failed to show ...
van den Brink, W., Reinout Wiers, Beraha, Esther, Bodewits, Pieter, van den Brink, Wim, Pieter Bodewits, Wiers, R.; id_orcid, Esther Beraha, Bodewits, P., Wiers, Reinout, Wim van den Brink, Beraha, E.   +11 more
core   +1 more source

Is R(+)‐Baclofen the best option for the future of Baclofen in alcohol dependence pharmacotherapy? Insights from the preclinical side

, 2021
International audienceFor several decades, studies conducted to evaluate the efficacy of RS(+/-)-Baclofen in the treatment of alcohol dependence yielded contrasting results.
Vorspan, Florence, Bloch, Vanessa, Jérôme Jeanblanc, Vanessa Bloch, Florence Vorspan, Echeverry-Alzate, Victor, Jeanblanc, Jerome, Sauton, Pierre, Marion Soichot, Mickael Naassila, Laurence Labat, Pierre Sauton, Labat, Laurence, Soichot, Marion, Naassïla, Mickaël, Victor Echeverry‐Alzate   +15 more
core   +1 more source

The Effect of Ginkgo on Baclofen Induced Amnesia using Passive Avoidance Learning and Memory in Rats [PDF]

Journal of Fasa University of Medical Sciences, 2015
Background & Objective: Ginkgo biloba is an herbal medicine that has a positive effect on improving memory. It prevents oxidative damage in mitochondria and cell death in a variety of Neuropathies.
Elaheh Nooshinfar, Mostafa Rezaei Tavirani, Akram Safaei, Yara Tambrchi   +3 more
doaj   +1 more source

Baclofen for alcohol use disorder. [PDF]

, 2023
Authors' conclusions: Baclofen likely reduces the risk of relapse to any drinking and increases the percentage of abstinent days, mainly among detoxified participants.
Silvia Minozzi, Roberta Agabio, Rosner, Susanne, Agabio R, Susanne Rösner, Minozzi S, Minozzi, Silvia, Saulle R, Agabio, Roberta, Rosella Saulle, Rösner S, Saulle, Rosella   +11 more
core   +1 more source

Systemic and intrathecal baclofen produce bladder antinociception in rats

BMC Urology, 2021
Background Baclofen, a clinically available GABAB receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception.
Timothy J. Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand   +4 more
doaj   +1 more source

Baclofen toxicity in a patient with baclofen pump

Ağrı - The Journal of The Turkish Society of Algology
Baclofen toxicity is a severe condition that can suppress brainstem reflexes, leading to coma and death. Therefore, emergency evaluation, correct diagnosis, and treatment are crucial to prevent any possible neurological sequelae. Here, we present a case of a patient with a previous baclofen pump, who was brought to the Emergency Department after being ...
Pınar, Gelener, Uğur, Özkula
openaire   +2 more sources

How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates

Frontiers in Psychiatry, 2018
Specialists in addiction medicine continue to debate whether baclofen is still indicated to treat alcohol use disorders in view of conflicting results as to its efficacy.
Nicolas Franchitto, Nicolas Franchitto, Nicolas Franchitto, Benjamin Rolland, Benjamin Rolland, Fanny Pelissier, Nicolas Simon   +6 more
doaj   +1 more source

Neonatal baclofen withdrawal following intrauterine exposure

Journal of Pediatric Rehabilitation Medicine, 2022
BACKGROUND: Pregnant women with spinal cord injuries are often advised to continue oral baclofen during pregnancy to manage spasticity, though the potential for adverse events in neonates is not well understood.
Marianne A. Mousigian, Sara A. Rosenblum, Erin E. Neil Knierbein, Alecia K. Daunter   +3 more
doaj   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, in collaboration with the Consensus Expert Panel (CEP) members, G. Alden Adkins, Brittany Adler, Hossein Ansari, Senada Arabelovic, Alan Baer, Denis Balaban, Shamik Bhattacharyya, Evelyn Bromet, Krishna Chaganti, Kamal Chemali, Melissa Cortez, Schartess Culpepper, Paul Dellaripa, Dana Direnzo, Daniel El Bogdadi, Robert Fearon, Mehrnez Fischbach, Judi Furlong, Christopher Gibbons, Rachael Gordon, Thomas Grader Beck, Syed Haider, Larry Hollenbeck, Chadwick R. Johr, Stuart S. Kassan, Brian King, Octavia Kincaid, Eugene Kissin, Vasileios Kyttaris, Lindsay Lally, Brandon M. Law, Janet Lewis, Scott M. Lieberman, Amanda Lusa, Joseph Lutt, Rashmi Maganti, Arthur M. Mandelin, Sara McCoy, Kerry Neall, Timothy Niewold, Anne Louise Oaklander, Ruben A. Peredo‐Wende, Lynn Petruzzi, Mark A. Porter, Guada Respicio Duque, Tania Reyna, Nathaniel M. Robbins, Elliot D. Rosenstein, Laura Rosow, Breanna Ruthrauff, Amit Sachdev, Nora Sandorfi, Sarah Schafer, Elena Schiopu, Chokkalingam Siva, Daniel Small, Sara M. Stern, Lauren Stiles, Susan Stoddard, Jinny Tavee, Donald Thomas, Edward L. Treadwell, Nagagopal Venna, Steven Vernino, Frederick B. Vivino, Brittany Weber, Sepideh Yadollahi, Huiying Yu, Scott Zashin   +88 more
wiley   +1 more source