Results 51 to 60 of about 15,483 (191)

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Frontiers in Psychiatry, 2018
Background: The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist, may reduce alcohol consumption, craving and promote abstinence.
Claire F. Durant, Louise M. Paterson, Sam Turton, Susan J. Wilson, James F. M. Myers, Suresh Muthukumaraswamy, Ashwin Venkataraman, Inge Mick, Susan Paterson, Tessa Jones, Limon K. Nahar, Rosa E. Cordero, David J. Nutt, Anne Lingford-Hughes   +13 more
doaj   +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson, Thomas Parkhouse, Chloe Burke, Monika Halicka, Jennifer C. Palmer, Hend Gabr, Rebecca Wilson, Katie E. Webster, Francesca Spiga, Sarah Dawson, Deborah M. Caldwell, Jennifer Scott, Julian P. T. Higgins, Jelena Savović   +13 more
wiley   +1 more source

Central sleep apnea caused by low dosage of baclofen: a case report

Journal of Medical Case Reports
Background Baclofen can relax muscle spasticity by inhibiting the transmission of both mono- and polysynaptic reflexes at the spinal cord. It has been increasingly used off-label for the management of spinal cord lesions or neurologic disorders. However,
Xiaoqiong Luo, Qidi Ding, Yanan Liu, Fang Han, Chenyu Li, Xiaosong Dong   +5 more
doaj   +1 more source

Risk Factors for Complications Following Paediatric Neuromuscular and Syndromic Scoliosis Correction Surgery: A Systematic Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Paediatric neuromuscular and syndromic scoliosis patients have multiple medical comorbidities that increase the risk of postoperative complications. There is a lack of consistent literature assessing the specific risk factors for complications following scoliosis correction surgery in this high‐risk cohort.
Mai Pham, Mia A. Percival, Moya Vandeleur, Giuliana Antolovich, Kris Lundine   +4 more
wiley   +1 more source

Evaluation of an innovative, green, and eco-friendly baclofen-loaded niosome (Baclosome) formulation for pain management by transdermal delivery [PDF]

Nanomedicine Journal
Objective(s): Baclofen, a muscle relaxant, exhibits limited dermal penetration, restricting its therapeutic efficacy. This study aimed to optimize baclofen delivery using ultrasonically manufactured niosomes (Baclosomes) for improved antinociceptive and ...
Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Seyede Nastaran Mousavi, Seyyed Mohammad Hassan Hashemi, Seyyed Mobin Rahimnia   +5 more
doaj   +1 more source

Baclofen overdose: A curious case of medical sales representative

Clinical Case Reports, 2022
In this case report, a medical sales representative consumed 250 mg of Baclofen out of curiosity. Baclofen has life‐threatening complications like seizures, respiratory depression, and coma.
Swotantra Gautam, Aakash Neupane, Mandita Chamlagain, Sandip Pokhrel, Durga Neupane, Rochana Acharya, Sagar Panthi   +6 more
doaj   +1 more source

Expanding the Phenotype of PARK‐PRKN to Spastic Paraplegia: A Report of Two Cases

Movement Disorders Clinical Practice, EarlyView.
Nicolas Geoffre, Thomas Ollivier, Guillaume Baille, Luc Defebvre, Vincent Huin, Eugenie Mutez   +5 more
wiley   +1 more source

A Swedish Population‐Based Study Found That Muscle Hypertonia in Children With Cerebral Palsy Varied by Age, Subtype, Functional Level, and Muscle Group

Acta Paediatrica, EarlyView.
ABSTRACT Aim We examined how lower limb muscle tone was related to age, sex, Gross Motor Function Classification System (GMFCS) level, and the cerebral palsy (CP) subtype in Swedish children with CP. Methods This registry‐based cohort study from 2023 to 2024 used data on all 3 216 children aged 1–15 from the Swedish follow‐up program and national CP ...
Gunnar. Hägglund, Ann. I. Alriksson‐Schmidt   +1 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source