Results 51 to 60 of about 21,556 (197)

Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Stiff person syndrome (SPS) is a rare disabling neurological condition with overlapping symptomatology with more common neurological conditions. Exaggerated exteroceptive reflex mechanisms are thought to play a role in its pathophysiology.
Belinda Cruse, Duncan Wilson, Hugo Morales Briceno, Pamela Garcia, Victor Zhang, Jessica Qiu, Tomas Kalincik, Neil Mahant, Victor Shue Chung Fung   +8 more
wiley   +1 more source

Baclofen overdose treated with continuous venovenous hemofiltration [PDF]

, 2015
Purpose: Overdose with baclofen, a derivative of the inhibitory neurotransmitter γ-aminobutyric acid, may lead to severe respiratory and central nervous system depression and can be life-threatening.
Meulendijks, Didier, Koks, Cornelis H W, Schellens, Jan H M, Huitema, Alwin D R, Pharmacoepidemiology and Clinical Pharmacology, Beijnen, Jos H., Sub Clinical Pharmacology, Khan, Saheed   +7 more
core   +2 more sources

Baclofen-induced neurotoxicity in a dialysis patient managed with continuous venovenous hemodialysis: A case report and literature review

Turkish Journal of Emergency Medicine
Despite documented cases of baclofen toxicity in individuals with kidney disease, the drug is widely prescribed for various medical conditions, primarily spasticity, hiccups, and multiple sclerosis.
Nejah F. Ellouze, Darpanarayan Hazra, Suad Al Abri   +2 more
doaj   +1 more source

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Suppression of alcohol-dependence using baclofen: a two-year observational study of 100 patients.

Frontiers in Psychiatry, 2012
Aims: The purpose of this study was to examine the long-term effects of baclofen in a large cohort of alcohol-dependent patients compliant to baclofen treatment.
Renaud eDe Beaurepaire
doaj   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Intrathecal Baclofen Pumps do not Accelerate Progression of Scoliosis in Quadriplegic Spastic Cerebral Plasy

Global Spine Journal, 2016
Introduction Intrathecal baclofen pumps are an effective treatment for spasticity in patients with cerebral palsy. Recently, concerns have been raised regarding the potential for intrathecal baclofen pumps to accelerate scoliosis progression and increase
Paul Rushton, Luigi Nasto, Ranjit Aujla, Michael Vloeberghs, Michael Grevitt   +4 more
doaj   +1 more source

Overtime Histological Changes in the Lungs after Intoxication with Baclofen Alone or in Combination with Ethanol (Experimental Study)

Общая реаниматология, 2023
The aim of the study was to evaluate the overtime histological changes in the lungs after intoxication with baclofen alone or in combination with ethanol.Materials and methods.
O. L. Romanova, M. L. Blagonravov, P. G. Dzhuvalyakov, V. I. Torshin, A. V. Ershov, E. Kh. Barinov   +5 more
doaj   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Resequencing of the auxiliary GABA(B) receptor subunit gene KCTD12 in chronic tinnitus [PDF]

, 2012
Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom sounds. Susceptibility factors remain largely unknown but GABA(B) receptor signaling has long been implicated in the response to treatment and, putatively,
V. Pimentel, Geis, S, Cárdenas-Conejo, E., Angelika eBauer, Cárdenas-Conejo, Z E, Langguth, B, Vanessa ePimentel, J. Itzhacki, Sand, P G, Zuge, Elisabeth, Sandra eGeis, Langguth, Berthold, Kleinjung, Tobias, Berthold eLangguth, Kleinjung, T, Philipp G Sand, Bauer, Angelika, S. Geis, A. Bauer, Itzhacki, J, Geis, Sandra, Itzhacki, Jacob, Elizabeth eCárdenas Conejo Zugey, Pimentel, Vanessa, Z. E. Cárdenas-Conejo, P. G. Sand, Pimentel, V, Tobias eKleinjung, B. Langguth, T. Kleinjung, Jacob eItzhacki, Bauer, A, Sand, Philipp G.   +32 more
core   +1 more source