Results 11 to 20 of about 15,483 (191)
Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans
Metabolites, 2012 STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD).
Raymundo Sanchez-Ponce +5 more
doaj +1 more source
The Neuropharmacology of Baclofen [PDF]
, 1988 Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the mammalian central nervous system [see: 36, 69, 92, 98]. GABAergic neurons have been identified throughout the central nervous system with histochemical techniques [see: 75].
Zieglgänsberger, Walter +2 more
openaire +2 more sources
Chinese Medicine, 2010 Background Chronic non-specific low back pain (LBP) is a prevalent (80%) and multi-dimensional illness. This study aims to test whether acupuncture, baclofen, or combined treatment with acupuncture and baclofen alleviates symptoms of non-specific chronic
Rastqar Ali +3 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori +5 more
wiley +1 more source
Comparison between baclofen and topiramate in alcohol dependence: A prospective study
Industrial Psychiatry Journal, 2019 Introduction: Baclofen and topiramate are GABAergic drugs, and both have been recommended for the treatment of alcohol dependence as anticraving agent. Several studies have demonstrated the effect of baclofen and topiramate as anticraving, but none has ...
Nimmi A Jose +3 more
doaj +1 more source
Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano +10 more
wiley +1 more source
A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder
Frontiers in Psychiatry, 2018 Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder (AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with many biological systems potentially involved in AUD, including transduction
Renaud de Beaurepaire
doaj +1 more source
O baclofeno intratecal no tratamento da espasticidade.
Acta Médica Portuguesa, 2006 The neuromotor techniques do not have good results in severe spasticity prevention and treatment (Ashworth Scale > or = 3). High doses of oral Baclofen are required, thus intrathecal baclofen is a current alternative.To assess the effectiveness of ...
Iolanda Veiros +2 more
doaj +1 more source
Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning [PDF]
Modern Medicine, 2019 Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life ...
Cristina Iolanda Vivisenco +1 more
doaj +1 more source
The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series.
Frontiers in Psychiatry, 2014 Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of ...
Renaud ede Beaurepaire
doaj +1 more source