Results 11 to 20 of about 21,556 (197)

Correlation between the single, high dose of ingested baclofen and clinical symptoms [PDF]

Annals of Agricultural and Environmental Medicine, 2017
Introduction and Objectives Baclofen is a drug used mainly to treat muscle spasticity. Its overdose can lead to life-threatening clinical symptoms, including acute respiratory failure requiring mechanical ventilation.
Jacek Sein Anand, Maciej Zając, Wojciech Waldman, Andrzej Wojtyła, Przemysław Biliński, Barbara Jaworska-Łuczak   +5 more
doaj   +2 more sources

Baclofen overdose presenting as psychosis with catatonia

Indian Journal of Psychological Medicine, 2017
Baclofen is a centrally acting gamma-aminobutyric acid receptor agonist with many therapeutic uses in neurology and psychiatry. An overdose of baclofen is known to cause serious side effects such as encephalopathy, seizures, respiratory depression, and ...
Abhinav Nahar, Mukku Shiva Shanker Reddy, Bhaskaran Andi Subramaniyam, Harish Thippeswamy, Prabha S Chandra, Santosh Kumar Chaturvedi   +5 more
doaj   +2 more sources

Effects of baclofen on swallow motor pattern [PDF]

Frontiers in Neurology
Baclofen is a GABAB receptor agonist used clinically to manage spasticity. It has also been associated with increased duration of mechanical ventilation and rates of aspiration pneumonitis. We hypothesized that baclofen would impair pharyngeal swallow, a
Nathan W. Fielder, Michael Frazure, Ivan Poliacek, Ivan Poliacek, Donald C. Bolser, Kimberly E. Iceman, Teresa Pitts   +6 more
doaj   +2 more sources

Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action [PDF]

, 1987
1. Intracellular recordings were obtained from neurones in layers 2 and 3 of the rat frontal neocortex in an in vitro slice preparation. Three distinct types of stimulation-evoked post-synaptic potentials were recorded in these neurones: excitatory post ...
Howe, James R., Zieglgänsberger, Walter, J R Howe, B Sutor, Sutor, Bernd, W Zieglgänsberger   +5 more
core   +2 more sources

Reduction of chronic non-specific low back pain: A randomised controlled clinical trial on acupuncture and baclofen

Chinese Medicine, 2010
Background Chronic non-specific low back pain (LBP) is a prevalent (80%) and multi-dimensional illness. This study aims to test whether acupuncture, baclofen, or combined treatment with acupuncture and baclofen alleviates symptoms of non-specific chronic
Rastqar Ali, Manaheji Homa, Zaringhalam Jalal, Zaringhalam Maryam   +3 more
doaj   +1 more source

Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning [PDF]

Modern Medicine, 2019
Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life ...
Cristina Iolanda Vivisenco, Coriolan Emil Ulmeanu   +1 more
doaj   +1 more source

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan, Stefan Brugger, Martina Kurejova, Tegeder Imgard, Gangadharan Vijayan, Imgard Tegeder, Gangadharan, Vijayan, Tegeder, Irmgard, Kuner Rohini, Kurejova, Martina, Rohini Kuner, Kurejova Martina, Nitin Agarwal, Bernhard Bettler, Brugger Stefan, Vijayan Gangadharan, Tegeder, Imgard, Agarwal, Nitin, Bettler Bernhard, Bettler, Bernhard, Agarwal Nitin, Kuner, Rohini   +21 more
core   +1 more source

Dose–Response Effect of Baclofen in Reducing Daily Alcohol Intake in Alcohol Dependence: Secondary Analysis of A Randomized, Double-Blind, Placebo-Controlled Trial

, 2011
Aims: To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence.
Leggio L, Caputo F, Landolfi R and the Baclofen Study Group, Addolorato G, Ferrulli A, Bedogni G, Gasbarrini G, Cardone S   +7 more
core   +2 more sources

Comparison between baclofen and topiramate in alcohol dependence: A prospective study

Industrial Psychiatry Journal, 2019
Introduction: Baclofen and topiramate are GABAergic drugs, and both have been recommended for the treatment of alcohol dependence as anticraving agent. Several studies have demonstrated the effect of baclofen and topiramate as anticraving, but none has ...
Nimmi A Jose, Pooja Yadav, Abhishek Kapoor, Ved Pal Mahla   +3 more
doaj   +1 more source

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation at Different Stimulus Parameters for Neuropathic Pain: A Randomized Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori, Koichi Hosomi, Asaya Nishi, Satoru Oshino, Haruhiko Kishima, Youichi Saitoh   +5 more
wiley   +1 more source