Results 11 to 20 of about 5,400 (175)
The Neuropharmacology of Baclofen [PDF]
, 1988 Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the mammalian central nervous system [see: 36, 69, 92, 98]. GABAergic neurons have been identified throughout the central nervous system with histochemical techniques [see: 75].
Zieglgänsberger, Walter +2 more
openaire +4 more sources
Correlation between the single, high dose of ingested baclofen and clinical symptoms
Annals of Agricultural and Environmental Medicine, 2017 Introduction and Objectives Baclofen is a drug used mainly to treat muscle spasticity. Its overdose can lead to life-threatening clinical symptoms, including acute respiratory failure requiring mechanical ventilation.
Jacek Sein Anand +5 more
doaj +2 more sources
Baclofen overdose presenting as psychosis with catatonia
Indian Journal of Psychological Medicine, 2017 Baclofen is a centrally acting gamma-aminobutyric acid receptor agonist with many therapeutic uses in neurology and psychiatry. An overdose of baclofen is known to cause serious side effects such as encephalopathy, seizures, respiratory depression, and ...
Abhinav Nahar +5 more
doaj +2 more sources
Effects of baclofen on swallow motor pattern [PDF]
Frontiers in NeurologyBaclofen is a GABAB receptor agonist used clinically to manage spasticity. It has also been associated with increased duration of mechanical ventilation and rates of aspiration pneumonitis. We hypothesized that baclofen would impair pharyngeal swallow, a
Nathan W. Fielder +6 more
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Treatment of recalcitrant cough with baclofen [PDF]
Italian Journal of Medicine, 2013 Background: Chronic dry cough is a debilitating symptom often refractory to standard antitussive therapy. It may result from increased sensitivity of the cough reflex. Baclofen, an agonist of gamma-aminobutyric acid (GABA), has been shown, in animals, to
Paolo Agostinis +9 more
doaj +2 more sources
Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action [PDF]
, 1987 1. Intracellular recordings were obtained from neurones in layers 2 and 3 of the rat frontal neocortex in an in vitro slice preparation. Three distinct types of stimulation-evoked post-synaptic potentials were recorded in these neurones: excitatory post ...
Howe, James R. +5 more
core +1 more source
Chinese Medicine, 2010 Background Chronic non-specific low back pain (LBP) is a prevalent (80%) and multi-dimensional illness. This study aims to test whether acupuncture, baclofen, or combined treatment with acupuncture and baclofen alleviates symptoms of non-specific chronic
Rastqar Ali +3 more
doaj +1 more source
TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS [PDF]
Kafrelsheikh Veterinary Medical Journal, 2004 The absorption of baclofen (BAC), a centrally acting antispastic agent with γ-amino acid structure as well as the influence of taurine (TAU) and caffeine (CAFF) on baclofen permeability was investigated by in-situ single-pass rat intestinal perfusion ...
H. Spahn-Langguth, A. Hanafy, C. Leisen
doaj +1 more source
, 2011 Aims: To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence.
Leggio L +7 more
core +2 more sources
Comparison between baclofen and topiramate in alcohol dependence: A prospective study
Industrial Psychiatry Journal, 2019 Introduction: Baclofen and topiramate are GABAergic drugs, and both have been recommended for the treatment of alcohol dependence as anticraving agent. Several studies have demonstrated the effect of baclofen and topiramate as anticraving, but none has ...
Nimmi A Jose +3 more
doaj +1 more source