Results 21 to 30 of about 15,483 (191)

TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS [PDF]

Kafrelsheikh Veterinary Medical Journal, 2004
The absorption of baclofen (BAC), a centrally acting antispastic agent with γ-amino acid structure as well as the influence of taurine (TAU) and caffeine (CAFF) on baclofen permeability was investigated by in-situ single-pass rat intestinal perfusion ...
H. Spahn-Langguth, A. Hanafy, C. Leisen
doaj   +1 more source

Baclofen Withdrawal–Induced Psychosis in the Setting of Renal Insufficiency

Journal of Investigative Medicine High Impact Case Reports, 2022
Baclofen is used to treat muscle spasticity, acting at GABA B receptors in the central nervous system. The abrupt cessation of baclofen causes baclofen withdrawal–induced psychosis. The risk is exacerbated if the patient has renal insufficiency or if the
Guilmette Amanda, Palushi Ambra, Shamsan Hundaol MD, Bhattacharyya Aniruddha MD, Michael Miriam MD   +4 more
doaj   +1 more source

Correlates of baclofen effectiveness in alcohol dependence

Indian Journal of Psychological Medicine, 2015
Alcohol dependence is a global concern. Baclofen has shown promise as an anti-craving agent but its efficiency remains to be settled. We reviewed 549 male cases diagnosed with alcohol dependence who received Acamprosate (201) or Baclofen (348).
Lekhansh Shukla, Tulika Shukla, Spandana Bokka, Arun Kandasamy, Vivek Benegal, Pratima Murthy, Prabhat Chand   +6 more
doaj   +1 more source

Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat

Frontiers in Physiology, 2021
Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown.
Wendy L. Olsen, Melanie Rose, Frank J. Golder, Cheng Wang, Julie C. Hammond, Donald C. Bolser   +5 more
doaj   +1 more source

The Effect of Ginkgo on Baclofen Induced Amnesia using Passive Avoidance Learning and Memory in Rats [PDF]

Journal of Fasa University of Medical Sciences, 2015
Background & Objective: Ginkgo biloba is an herbal medicine that has a positive effect on improving memory. It prevents oxidative damage in mitochondria and cell death in a variety of Neuropathies.
Elaheh Nooshinfar, Mostafa Rezaei Tavirani, Akram Safaei, Yara Tambrchi   +3 more
doaj   +1 more source

Baclofen toxicity in a patient with baclofen pump

Ağrı - The Journal of The Turkish Society of Algology
Baclofen toxicity is a severe condition that can suppress brainstem reflexes, leading to coma and death. Therefore, emergency evaluation, correct diagnosis, and treatment are crucial to prevent any possible neurological sequelae. Here, we present a case of a patient with a previous baclofen pump, who was brought to the Emergency Department after being ...
Pınar, Gelener, Uğur, Özkula
openaire   +2 more sources

How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates

Frontiers in Psychiatry, 2018
Specialists in addiction medicine continue to debate whether baclofen is still indicated to treat alcohol use disorders in view of conflicting results as to its efficacy.
Nicolas Franchitto, Nicolas Franchitto, Nicolas Franchitto, Benjamin Rolland, Benjamin Rolland, Fanny Pelissier, Nicolas Simon   +6 more
doaj   +1 more source

Systemic and intrathecal baclofen produce bladder antinociception in rats

BMC Urology, 2021
Background Baclofen, a clinically available GABAB receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception.
Timothy J. Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand   +4 more
doaj   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source