A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder
Frontiers in Psychiatry, 2018 Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder (AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with many biological systems potentially involved in AUD, including transduction
Renaud de Beaurepaire
doaj +1 more source
Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano +10 more
wiley +1 more source
Characteristics of long-duration inhibitory postsynaptic potentials in rat neocortical neurons in vitro [PDF]
, 1987 1. The characteristics of long-duration inhibitory postsynaptic potentials (l-IPSPs) which are evoked in rat frontal neocortical neurons by local electrical stimulation were investigated with intracellular recordings from anin vitro slice preparation.
Howe, James R. +2 more
core +1 more source
O baclofeno intratecal no tratamento da espasticidade.
Acta Médica Portuguesa, 2006 The neuromotor techniques do not have good results in severe spasticity prevention and treatment (Ashworth Scale > or = 3). High doses of oral Baclofen are required, thus intrathecal baclofen is a current alternative.To assess the effectiveness of ...
Iolanda Veiros +2 more
doaj +1 more source
Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]
, 2007 Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core +1 more source
TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS [PDF]
Kafrelsheikh Veterinary Medical Journal, 2004 The absorption of baclofen (BAC), a centrally acting antispastic agent with γ-amino acid structure as well as the influence of taurine (TAU) and caffeine (CAFF) on baclofen permeability was investigated by in-situ single-pass rat intestinal perfusion ...
H. Spahn-Langguth, A. Hanafy, C. Leisen
doaj +1 more source
The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series.
Frontiers in Psychiatry, 2014 Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of ...
Renaud ede Beaurepaire
doaj +1 more source
Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat
Frontiers in Physiology, 2021 Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown.
Wendy L. Olsen +5 more
doaj +1 more source
Lung Histopathology in Baclofen Intoxication [PDF]
, 2021 The aim of the study: to assess the lung histopathology in acute intoxication with baclofen alone and its combination with alcohol (in the same dose) 3 hours after the ingestion.Materials and methods.
M. A. Golubev +4 more
core +1 more source
Correlates of baclofen effectiveness in alcohol dependence
Indian Journal of Psychological Medicine, 2015 Alcohol dependence is a global concern. Baclofen has shown promise as an anti-craving agent but its efficiency remains to be settled. We reviewed 549 male cases diagnosed with alcohol dependence who received Acamprosate (201) or Baclofen (348).
Lekhansh Shukla +6 more
doaj +1 more source