Results 21 to 30 of about 5,400 (175)
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori +5 more
wiley +1 more source
Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano +10 more
wiley +1 more source
A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder
Frontiers in Psychiatry, 2018 Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder (AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with many biological systems potentially involved in AUD, including transduction
Renaud de Beaurepaire
doaj +1 more source
Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning [PDF]
Modern Medicine, 2019 Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life ...
Cristina Iolanda Vivisenco +1 more
doaj +1 more source
Characteristics of long-duration inhibitory postsynaptic potentials in rat neocortical neurons in vitro [PDF]
, 1987 1. The characteristics of long-duration inhibitory postsynaptic potentials (l-IPSPs) which are evoked in rat frontal neocortical neurons by local electrical stimulation were investigated with intracellular recordings from anin vitro slice preparation.
Howe, James R. +2 more
core +1 more source
O baclofeno intratecal no tratamento da espasticidade.
Acta Médica Portuguesa, 2006 The neuromotor techniques do not have good results in severe spasticity prevention and treatment (Ashworth Scale > or = 3). High doses of oral Baclofen are required, thus intrathecal baclofen is a current alternative.To assess the effectiveness of ...
Iolanda Veiros +2 more
doaj +1 more source
Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]
, 2007 Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core +1 more source
The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series.
Frontiers in Psychiatry, 2014 Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of ...
Renaud ede Beaurepaire
doaj +1 more source
Correlates of baclofen effectiveness in alcohol dependence
Indian Journal of Psychological Medicine, 2015 Alcohol dependence is a global concern. Baclofen has shown promise as an anti-craving agent but its efficiency remains to be settled. We reviewed 549 male cases diagnosed with alcohol dependence who received Acamprosate (201) or Baclofen (348).
Lekhansh Shukla +6 more
doaj +1 more source
Baclofen Withdrawal–Induced Psychosis in the Setting of Renal Insufficiency
Journal of Investigative Medicine High Impact Case Reports, 2022 Baclofen is used to treat muscle spasticity, acting at GABA B receptors in the central nervous system. The abrupt cessation of baclofen causes baclofen withdrawal–induced psychosis. The risk is exacerbated if the patient has renal insufficiency or if the
Guilmette Amanda +4 more
doaj +1 more source