Results 101 to 110 of about 21,556 (197)

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Orthopedic surgery in children with intrathecal baclofen pumps

Journal of Pediatric Rehabilitation Medicine, 2013
AIMS: Children with cerebral palsy often have severe spasticity leading to deformity that requires multiple orthopedic surgeries. Intrathecal baclofen pump implantation effectively decreases severe spasticity. The objective of this study was to determine
Judith L. Gooch, Molly McFadden, Wende Oberg   +2 more
doaj   +1 more source

A Swedish Population‐Based Study Found That Muscle Hypertonia in Children With Cerebral Palsy Varied by Age, Subtype, Functional Level, and Muscle Group

Acta Paediatrica, Volume 115, Issue 10, Page 2261-2268, October 2026.
ABSTRACT Aim We examined how lower limb muscle tone was related to age, sex, Gross Motor Function Classification System (GMFCS) level, and the cerebral palsy (CP) subtype in Swedish children with CP. Methods This registry‐based cohort study from 2023 to 2024 used data on all 3 216 children aged 1–15 from the Swedish follow‐up program and national CP ...
Gunnar. Hägglund, Ann. I. Alriksson‐Schmidt   +1 more
wiley   +1 more source

Baclofen und Baclofen-Prodrugs: Deskriptive und mechanistische Studien zum Membrantransport

, 2012
Baclofen wird zur Behandlung von schweren spastischen Zuständen eingesetzt. Frühere Studien zeigten, dass die Konzentration von Baclofen im Zentralnervensystem (ZNS) nach peroraler oder intravenöser Applikation nur sehr gering sind und es somit schwierig
Pendl, Elisabeth
core   +1 more source

Persistent Post‐Traumatic Brain Injury Hiccups Unresponsive to Standard Agents: Resolution Associated With Levetiracetam Therapy

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Post‐traumatic hiccups are an uncommon but distressing complication of traumatic brain injury (TBI), often resistant to conventional pharmacological agents, and the underlying mechanism may involve central neurological disruption of inhibitory pathways rather than gastrointestinal or metabolic aetiologies. We report a male patient in his early
Rostom Karajeh, Ranya Abu Khalaf, Mostafa Ibraheem Abo Alrob, Saif Khaled Abdalhadi Azzam, Youssef Abdelqader Alsaeed   +4 more
wiley   +1 more source

Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebocontrolled trial. Alcohol Alcohol

, 2011
-Aims: To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence.
Giorgio Bedogni, Lorenzo Leggio, Fabio Caputo, Raffaele Landolfi, Giovanni Gasbarrini, Giovanni Addolorato, Silvia Cardone, Anna Ferrulli, Baclofen Study Group   +8 more
core  

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

ChemistryEurope, Volume 4, Issue 9, September 2026.
A broadly applicable synthetic platform based on a DOS/LOS‐like strategy is implemented for the case of sp3‐enriched isoxazole/isoxazoline building blocks. The method is based on a [3+2] cycloaddition of nitroalkanes and various alkenes or alkynes. The utility of the proposed approach is illustrated by the discovery of JAK2‐selective inhibitors.
Bohdan A. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova, Bohdan S. Sosunovych, Bohdan V. Vashchenko, Oleksandr Zginnyk, Anna Beshtynarska, Nataliia Shliakhtova, Petro Borysko, Angelina V. Biitseva, Konstantin S. Gavrilenko, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko   +12 more
wiley   +1 more source

Rhizotomy as a treatment for hypertonia, spasticity, and dystonia

Developmental Medicine &Child Neurology, EarlyView.
Shashank Rajkumar, Jeffrey S. Raskin
wiley   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

The Prevalence of Neuropathic Pain in Multiple Sclerosis—A Systematic Review and Meta‐Analysis Using the NeuPSIG Algorithm

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background and Objectives Multiple sclerosis (MS) is a neurodegenerative disorder frequently leading to neuropathic pain. Due to the neurodegenerative nature, the diagnosis of neuropathic pain remains challenging. A grading system has been developed providing an overview of diagnostic certainty (i.e., possible, probable and definite). Since no
Rasmus C. Jungersen, Victor K. Baccaro, Lars G. Hvid, Ulrik Dalgas, Morten Hoegh   +4 more
wiley   +1 more source