Results 51 to 60 of about 109,615 (132)

A Selective Cortico‐Limbic Network Organizes Behavior During Reward Seeking Under Threat

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
In the SDAmC task, rats step down from safety and cross a threat‐associated context for saccharin. PL limits approach, pIC supports risk assessment, BLA supports avoidance across motivational states, and NAc supports goal‐directed behavior under conflict; IL, lOFC, aIC, and LHb showed no detectable effects.
Rodrigo O. Sierra, Leticia Ramirez‐Lugo, Elizabeth Illescas‐Huerta, Axel R. Bolaños, Francisco Sotres‐Bayon   +4 more
wiley   +1 more source

Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]

, 2007
Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen, Asta Prescott, Caroline Folkersen, Jens Laigaard, Atena Saito, Caroline Lando Klammer, Mik Wetterslev, Emil Ipsen Ørskov, Mathilde Fahrendorff, Rebecca Kiær, Helene Holm Laigaard, Nichlas Hovmand, Lars Hyldborg Lundstrøm, Sebastian Buhl Rasmussen, Anders Kehlet Nørskov, Markus Harboe Olsen   +15 more
wiley   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Baclofen Intoxication

, 2015
Baclofen is a β-(ρ-chlorophenyl) derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is usually prescribed for spasticity of spinal cord origin, intractable hiccup, trigeminal neuralgia, hemifacial spasm, and tardive dyskinesia.
İlkin Çankayalı, Karaca, Iclal, Demirag, Kubilay, İclal Karaca, Cankayali, Ilkin, Karakoc, Ozge, Uyar, Mehmet, Bor, Canan, Mehmet Uyar, Özge Karakoç, Kubilay Demirağ, Canan Bor   +11 more
core   +1 more source

Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia

, 2013
Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders. The effects of baclofen on voluntary motor output are limited and not yet understood.
Bunday, K.L., Perez, M.A., Chen, R., Barry, M.D.   +3 more
core   +1 more source

Intrathecal baclofen pumps in the management of hypertonia in childhood:a UK and Ireland wide survey

, 2021
Background: Intrathecal baclofen (ITB) is a useful treatment for hypertonia where non-invasive treatments have been ineffective or poorly tolerated. There is an absence of national guidance on selection criteria and a lack of literature regarding patient
Calisto, Amedeo, Kehoe, Joanne, Bellis, Lucy, Lodh, Rajib, Crimmins, Darach, Ammar, Amr, Mordekar, Santosh R., Zaki, Hesham, Leonard, Jane, Whitney, Andrea, Eunson, Paul, Forsyth, Rob J., Smith, Rachel, Goodden, John, Kumar, Ram, Smith, Martin, Kaminska, Margaret, Kirkpatrick, Martin, Pettorini, Benedetta, Amin, Sam, Brink, Phillip, Lumsden, Daniel E., Vloeberghs, Michael, Sneade, Christine, Lording, Alice, Miller, Russell, Martin, Katherine   +26 more
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Correlation between the single, high dose of ingested baclofen and clinical symptoms [PDF]

, 2017
Introduction and Objectives Baclofen is a drug used mainly to treat muscle spasticity. Its overdose can lead to life-threatening clinical symptoms, including acute respiratory failure requiring mechanical ventilation.
Waldman, Wojciech, Biliński, Przemysław, Wojciech Waldman, Jacek Anand, Andrzej Wojtyła, Jaworska-Łuczak, Barbara, Przemysław Biliński, Maciej Zając, Sein Anand, Jacek, Jacek Sein Anand, Barbara Jaworska-Łuczak, Zając, Maciej, Wojtyła, Andrzej   +12 more
core   +1 more source

Stability of a Baclofen and Clonidine Hydrochloride Admixture for Intrathecal Administration

, 2001
Implantable infusion pumps for the intrathecal administration of analgesics are commonly used in the treatment of severe or intractable chronic pain. Drugs used in these pumps include morphine, baclofen, clonidine, hydromorphone, meperidine, fentanyl ...
Donald A. Godwin, Nae-Hwa Kim, Robert Zuniga   +2 more
core   +1 more source

Damages on pumps and systems: the handbook for the operation of centrifugal pumps

, 2014
Damage on Pumps and Systems. The Handbook for the Operation of Centrifugal Pumps offers a combination of the theoretical basics and practical experience for the operation of circulation pumps in the engineering industry.
Merkle, Thomas., Merkle, Thomas
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