Results 51 to 60 of about 13,376 (252)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
O consumo de organismos marinhos, especialmente moluscos bivalves, pode afetar a saúde humana, uma vez que os mesmos concentram em seus tecidos, partículas em suspensão, incluindo microrganismos patogênicos. A região de Cananéia é a maior produtora de
Eliete Rodrigues BALLESTEROS +5 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Aeromonas spp. em água de pisciculturas da região da baixada ocidental Maranhense
Dentre os agentes bacterianos amplamente distribuídos no ecossistema aquático destacam-se os membros da família Aeromonadaceae, podendo ser detectados tanto nos peixes como na água desse sistema. Este estudo foi realizado com o objetivo de verificar
Rejeana Márcia Lima SILVA +5 more
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
O estado de degradação e, ou, recuperação de diferentes sítios de uma área de mineração de ferro no município de Mariana (MG) foi avaliado pela atividade microbiana, número de esporos de fungos micorrízicos arbusculares (FMA) e população total de fungos ...
A. V. Trindade +2 more
doaj +1 more source
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
INFECÇÃO BACTERIANA HOSPITALAR EM PACIENTES SUBMETIDOS A TRANSPLANTE HEPÁTICO EM 2008
INTRODUÇÃO: A infecção hospitalar representa um grave problema de saúde pública. É definido como aquela adquirida no hospital que se manifesta após 72 horas de internação ou mesmo após a sua alta, desde que se relacione com o período de internamento Mies
Maria Ozilene Rodrigues Batista +4 more
doaj +2 more sources
Ruminal fluid from steers fed on pasture was incubated with artificial media at pH 5.5 and 7.0 in two experiments. In the first, the effect of monensin level on resistance of ruminal bacteria to potassium depletion was evaluated; in the second, effects ...
W.M. Leopoldino +8 more
doaj +1 more source
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source

