Bacterial Amyloids: The Link between Bacterial Infections and Autoimmunity. [PDF]
Trends Microbiol, 2019 Molecular mimicry is a common mechanism used by many bacteria to evade immune responses. In recent years, it has become evident that bacteria also decorate the extracellular matrix (ECM) of their biofilms with molecules that resemble those of the host.
Nicastro L, Tükel Ç.
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SynBio and the Boundaries between Functional and Pathogenic RepA-WH1 Bacterial Amyloids [PDF]
mSystems, 2020 Amyloids are protein polymers that were initially linked to human diseases. Across the whole Tree of Life, many disease-unrelated proteins are now emerging for which amyloids represent distinct functional states.
Rafael Giraldo
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Methods Mol Biol, 2018 Many bacteria can assemble functional amyloid fibers on their cell surface. Most bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with other cells. Bacterial amyloids, like all functional amyloids, share structural and biochemical properties with disease-associated eukaryotic amyloids.
Evans ML, Gichana E, Zhou Y, Chapman MR.
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Methods Mol Biol, 2012 Many bacteria can assemble functional amyloid fibers on their cell surface. The majority of bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with another cell. Bacterial amyloids, like all functional amyloids, share structural and biochemical properties with disease-associated eukaryotic ...
Zhou Y, Blanco LP, Smith DR, Chapman MR.
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Functional Bacterial Amyloids: Understanding Fibrillation, Regulating Biofilm Fibril Formation and Organizing Surface Assemblies [PDF]
Molecules, 2022 Functional amyloid is produced by many organisms but is particularly well understood in bacteria, where proteins such as CsgA (E. coli) and FapC (Pseudomonas) are assembled as functional bacterial amyloid (FuBA) on the cell surface in a carefully ...
Thorbjørn Vincent Sønderby +2 more
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New insight into the molecular control of bacterial functional amyloids [PDF]
Frontiers in Cellular and Infection Microbiology, 2015 Amyloid protein structure has been discovered in a variety of functional or pathogenic contexts. What distinguishes the former from the latter is that functional amyloid systems possess dedicated molecular control systems that determine the timing ...
Stephen eMatthews, Jonathan eTaylor
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The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions [PDF]
Advanced ScienceAmyloids are highly ordered β‐sheet‐rich structures that are well conserved across the domains of life. Amyloids have a unique repetitive structure that enables autocatalytic self‐replication.
Divya Kolli +3 more
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Fold modulating function: Bacterial toxins to functional amyloids [PDF]
Frontiers in Microbiology, 2014 Many bacteria produce cytolytic toxins that target host cells or other competing microbes. It is well known that environmental factors control toxin expression, however recent work suggests that some bacteria manipulate the fold of these protein toxins ...
Adnan Khawaja Syed, Blaise R Boles
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Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface [PDF]
Frontiers in ImmunologyC-reactive protein (CRP) protects mice during the initial stages of Streptococcus pneumoniae infection. In order to be protective against all stages of infection, we hypothesize that CRP binds to two different ligands on pneumococci.
Alok Agrawal +3 more
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Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation [PDF]
mBio, 2018 Curli amyloid fibers are produced as part of the extracellular biofilm matrix and are composed primarily of the major structural subunit CsgA. The CsgE chaperone facilitates the secretion of CsgA through CsgG by forming a cap at the base of the nonameric
Roger D. Klein +13 more
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