Results 41 to 50 of about 286,033 (295)

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes

Nature Communications, 2019
GpsB is a cytosolic protein that modulates bacterial cell wall synthesis by interacting with cytoplasmic domains of peptidoglycan synthases. Here, Cleverley et al.
Robert M. Cleverley, Zoe J. Rutter, Jeanine Rismondo, Federico Corona, Ho-Ching Tiffany Tsui, Fuad A. Alatawi, Richard A. Daniel, Sven Halbedel, Orietta Massidda, Malcolm E. Winkler, Richard J. Lewis   +10 more
doaj   +1 more source

Tetracycline hypersensitivity of an ezrA mutant links GalE and TseB (YpmB) to cell division [PDF]

, 2015
Cell division in bacteria is initiated by the polymerization of FtsZ into a ring-like structure at midcell that functions as a scaffold for the other cell division proteins.
Daniel, R.A., Eva Rietkötter, Pamela eGamba, Pamela Gamba, Richard A. Daniel, Gamba, P., Hamoen, L.W., Eva eRietkötter, Leendert W. Hamoen, Rietkötter, E., Hamoen, L.W.; id_orcid   +10 more
core   +1 more source

Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP

Nature Communications, 2020
Protein, MatP, binds to and delays segregation of the ter region of the bacterial chromosome before cell division. Here, the authors show that MatP displays multiple activities to promote optimal pairing of sister ter regions until cell division.
Estelle Crozat, Catherine Tardin, Maya Salhi, Philippe Rousseau, Armand Lablaine, Tommaso Bertoni, David Holcman, Bianca Sclavi, Pietro Cicuta, François Cornet   +9 more
doaj   +1 more source

Amplifying the innate immune response : cell-cell propagation of proinflammatory signals during bacterial infection [PDF]

, 2012
The enteroinvasive bacterium Shigella flexneri uses multiple secreted effector proteins to downregulate interleukin-8 (IL-8) expression in infected epithelial cells. Nevertheless, massive IL-8 secretion is observed in shigellosis. In this thesis, a novel
Kasper, Christoph Alexander
core   +1 more source

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria

mBio
The NLRP11 protein is only expressed in primates and participates in the activation of the canonical NLRP3 and non-canonical NLRP3 inflammasome activation after infection with gram-negative bacteria. Here, we generated a series of defined NLRP11 deletion
Mateusz Szczerba, Akshaya Ganesh, María Luisa Gil-Marqués, Volker Briken, Marcia B. Goldberg   +4 more
doaj   +1 more source

Investigating the effect of bacteriophages on bacterial FtsZ localisation

Frontiers in Cellular and Infection Microbiology, 2022
Escherichia coli is one of the most common Gram-negative pathogens and is responsible for infection leading to neonatal meningitis and sepsis. The FtsZ protein is a bacterial tubulin homolog required for cell division in most species, including E.
Gurneet K. Dhanoa, Inbar Kushnir, Udi Qimron, David I. Roper, Antonia P. Sagona   +4 more
doaj   +1 more source

The conserved DNA-binding protein WhiA is involved in cell division in Bacillus subtilis [PDF]

, 2013
Bacterial cell division is a highly coordinated process that begins with the polymerization of the tubulin-like protein FtsZ at midcell. FtsZ polymerization is regulated by a set of conserved cell division proteins, including ZapA.
Siersma, T., Claessen, D., Surdova, K., Jonker, M.J., Errington, J., Gamba, P., Hamoen, L.W., Hamoen, L.W.; id_orcid   +7 more
core   +1 more source

Probing bacterial cell wall growth by tracing wall-anchored protein complexes

Nature Communications, 2021
Dynamic cell wall assembly is key to cell shape maintenance during bacterial growth. Here, the authors present a method that allows high-resolution analysis of active and inert zones of cell wall growth during bacterial elongation.
Yi-Jen Sun, Fan Bai, An-Chi Luo, Xiang-Yu Zhuang, Tsai-Shun Lin, Yu-Cheng Sung, Yu-Ling Shih, Chien-Jung Lo   +7 more
doaj   +1 more source

Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement [PDF]

, 2010
Compartmentalization is an important process, since it allows the segregation of metabolic activities and, in the era of synthetic biology, represents an important tool by which defined microenvironments can be created for specific metabolic functions ...
Prentice, M.B., Mulvihill, D.P., Frank, S., Bhella, D., Frank, Stefanie, Parsons, J.B., Bhella, David, Prentice, Michael B., Liang, M., Mulvihill, Daniel P., Warren, Martin J., Parsons, Joshua B., Warren, M.J., Liang, Mingzhi   +13 more
core   +1 more source

The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action

Nature Communications
Daptomycin is a lipopeptide antibiotic, commonly used as last resort treatment against multidrug resistant Gram-positive pathogens. Despite its clinical success, the mechanism through which daptomycin exerts its antibacterial properties has remained ...
Jessica A. Buttress, Ann-Britt Schäfer, Alan Koh, Jessica Wheatley, Katarzyna Mickiewicz, Michaela Wenzel, Henrik Strahl   +6 more
doaj   +1 more source