Results 41 to 50 of about 7,099,213 (281)

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes

Nature Communications, 2019
GpsB is a cytosolic protein that modulates bacterial cell wall synthesis by interacting with cytoplasmic domains of peptidoglycan synthases. Here, Cleverley et al.
Robert M. Cleverley, Zoe J. Rutter, Jeanine Rismondo, Federico Corona, Ho-Ching Tiffany Tsui, Fuad A. Alatawi, Richard A. Daniel, Sven Halbedel, Orietta Massidda, Malcolm E. Winkler, Richard J. Lewis   +10 more
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP

Nature Communications, 2020
Protein, MatP, binds to and delays segregation of the ter region of the bacterial chromosome before cell division. Here, the authors show that MatP displays multiple activities to promote optimal pairing of sister ter regions until cell division.
Estelle Crozat, Catherine Tardin, Maya Salhi, Philippe Rousseau, Armand Lablaine, Tommaso Bertoni, David Holcman, Bianca Sclavi, Pietro Cicuta, François Cornet   +9 more
doaj   +1 more source

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria

mBio
The NLRP11 protein is only expressed in primates and participates in the activation of the canonical NLRP3 and non-canonical NLRP3 inflammasome activation after infection with gram-negative bacteria. Here, we generated a series of defined NLRP11 deletion
Mateusz Szczerba, Akshaya Ganesh, María Luisa Gil-Marqués, Volker Briken, Marcia B. Goldberg   +4 more
doaj   +1 more source

ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation [PDF]

Open Biology, 2016
In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes ...
Magdalena Donczew, Paweł Mackiewicz, Agnieszka Wróbel, Klas Flärdh, Jolanta Zakrzewska-Czerwińska, Dagmara Jakimowicz   +5 more
doaj   +1 more source

Investigating the effect of bacteriophages on bacterial FtsZ localisation

Frontiers in Cellular and Infection Microbiology, 2022
Escherichia coli is one of the most common Gram-negative pathogens and is responsible for infection leading to neonatal meningitis and sepsis. The FtsZ protein is a bacterial tubulin homolog required for cell division in most species, including E.
Gurneet K. Dhanoa, Inbar Kushnir, Udi Qimron, David I. Roper, Antonia P. Sagona   +4 more
doaj   +1 more source

Bacterial Growth and Cell Division: a Mycobacterial Perspective [PDF]

Microbiology and Molecular Biology Reviews, 2008
SUMMARYThe genusMycobacteriumis best known for its two major pathogenic species,M. tuberculosisandM. leprae, the causative agents of two of the world's oldest diseases, tuberculosis and leprosy, respectively.M. tuberculosiskills approximately two million people each year and is thought to latently infect one-third of the world's population.
Hett, Erik C., Rubin, Eric J.
openaire   +4 more sources

Membrane potential is important for bacterial cell division [PDF]

Proceedings of the National Academy of Sciences, 2010
Many cell division-related proteins are located at specific positions in the bacterial cell, and this organized distribution of proteins requires energy. Here, we report that the proton motive force, or more specifically the (trans)membrane potential, is directly involved in protein localization.
Strahl H, Hamoen LW
openaire   +3 more sources

The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action

Nature Communications
Daptomycin is a lipopeptide antibiotic, commonly used as last resort treatment against multidrug resistant Gram-positive pathogens. Despite its clinical success, the mechanism through which daptomycin exerts its antibacterial properties has remained ...
Jessica A. Buttress, Ann-Britt Schäfer, Alan Koh, Jessica Wheatley, Katarzyna Mickiewicz, Michaela Wenzel, Henrik Strahl   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source