Results 61 to 70 of about 286,033 (295)

The In Vitro Non-Tetramerizing ZapA^I83E Mutant Is Unable to Recruit ZapB to the Division Plane In Vivo in Escherichia coli [PDF]

, 2020
Bacterial cell division is guided by filamenting temperature-sensitive Z (FtsZ) treadmilling at midcell. FtsZ itself is regulated by FtsZ-associated proteins (Zaps) that couple it to different cellular processes. Z-associated protein A (ZapA) is known to
Tanneke den Blaauwen, den Blaauwen, T.; id_orcid, Meiresonne, N.Y., den Blaauwen, T., Nils Y. Meiresonne   +4 more
core   +1 more source

Membrane potential is important for bacterial cell division [PDF]

Proceedings of the National Academy of Sciences, 2010
Many cell division-related proteins are located at specific positions in the bacterial cell, and this organized distribution of proteins requires energy. Here, we report that the proton motive force, or more specifically the (trans)membrane potential, is directly involved in protein localization.
Strahl H, Hamoen LW
openaire   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The minimalistic divisome reveals power of the cell division machinery [PDF]

, 2019
Bacterial resistance towards antibiotics is an increasing worldwide health problem with the potential to seriously endanger modern medicine without prudent measures.
Saaki, T.N.V.
core  

Free SepF interferes with recruitment of late cell division proteins [PDF]

, 2017
The conserved cell division protein SepF aligns polymers of FtsZ, the key cell division protein in bacteria, during synthesis of the (Fts)Z-ring at midcell, the first stage in cytokinesis.
Wenzel, M., Jonker, M.J., Hamoen, L.W., Gao, Y., Hamoen, L.W.; id_orcid   +4 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Prokaryotic cell division: flexible and diverse

, 2013
Gram-negative rod-shaped bacteria have different approaches to position the cell division initiating Z-ring at the correct moment in their cell division cycle.
den Blaauwen, T.; id_orcid, den Blaauwen, T.   +1 more
core   +1 more source

Probing the benzofuroquinolinium derivative as a potent antibacterial agent through the inhibition of FtsZ activity

Journal of Pharmacological Sciences, 2018
A benzofuroquinolinium derivative that exhibits excellent cell division inhibitory effect was discovered through cell-based screening approach. This compound possesses potent antimicrobial activity against both Gram-positive and Gram-negative bacteria ...
Ning Sun, Li Ban, Ming Li, Zhiyuan Fang, Xiaomei Li, Wenxia Yao, Jinghui Pan, Yujing Lu, Zhihua Liu, Wing-Leung Wong   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli

, 2013
The rod-shaped bacterium Escherichia coli grows by insertion of peptidoglycan into the lateral wall during cell elongation and synthesis of new poles during cell division.
Verheul, Jolanda, Hoogendoorn, Eelco, Alexeeva, Svetlana, Vollmer, Waldemar, Banzhaf, Manuel; id_orcid, van der Ploeg, René, Vollmer, W., Vischer, Norbert O E, Postma, Marten, Verheul, J., Postma, M., Alexeeva, S., Verheul, J.; id_orcid, Alexeeva, S.V., van der Ploeg, R., den Blaauwen, T.; id_orcid, Banzhaf, M., Vischer, N.O.E., den Blaauwen, T., Blaauwen, T., den, Hoogendoorn, E., Ploeg, R., van der, den Blaauwen, Tanneke   +22 more
core   +1 more source