Results 71 to 80 of about 1,235,601 (229)
High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion
Genomics, Proteomics & Bioinformatics, 2023 The high host genetic background of tissue biopsies hinders the application of shotgun metagenomic sequencing in characterizing the tissue microbiota. We proposed an optimized method that removed host DNA from colon biopsies and examined the effect on ...
Wing Yin Cheng +8 more
doaj
DnaG Primase—A Target for the Development of Novel Antibacterial Agents
Antibiotics, 2018 The bacterial primase—an essential component in the replisome—is a promising but underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different structure than the human primase.
Stefan Ilic +5 more
doaj +1 more source
Dna Supercoiling and Bacterial Gene Expression [PDF]
Science Progress, 2006 DNA in bacterial cells is maintained in a negatively supercoiled state. This contributes to the organization of the bacterial nucleoid and also influences the global gene expression pattern in the cell through modulatory effects on transcription.
openaire +3 more sources
Co- variation in soil biodiversity and biogeochemistry in northern and southern Victoria Land, Antarctica [PDF]
, 2006 Data from six sites in Victoria Land (72–77°S) investigating co-variation in soil communities (microbial and invertebrate) with biogeochemical properties showthe influence of soil properties on habitat suitability varied among local landscapes as well as
Adams, Byron J. +6 more
core +2 more sources
Communications Biology, 2023 Two potent inhibitors PPEF and BPVF of bacterial TopoIA enzymes function by impairing DNA binding and thus DNA cleavage and relaxation activities of bacterial topoisomerase I enzymes.
Vikas Maurya +9 more
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Gram-negative bacterial molecules associate with Alzheimer disease pathology. [PDF]
, 2016 ObjectiveWe determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative ...
DeCarli, Charles +5 more
core +1 more source
Mutagenic cost of ribonucleotides in bacterial DNA [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance DNA polymerases frequently incorporate ribonucleotides in place of deoxyribonucleotides during genome replication. RNase HII is responsible for initiating the removal of ribonucleotide errors across all three domains of life.
William G. Hirst +4 more
openaire +3 more sources
Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Bacterial translocation is a frequent event in cirrhosis leading to an increased inflammatory response. Splanchnic adrenergic system hyperactivation has been related with increased bacterial translocation. We aim at evaluating the interacting
Pedro Zapater +8 more
doaj +1 more source
Molecular mechanisms of autoimmunity triggered by microbial infection [PDF]
, 2005 Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives.
Anders, Hans-Joachim +3 more
core +2 more sources
Long-term persistence of bacterial DNA [PDF]
Current Biology, 2004 The persistence of bacterial DNA over geological timespans remains a contentious issue. In direct contrast to in vitro based predictions, bacterial DNA and even culturable cells have been reported from various ancient specimens many million years (Ma) old [1–8].
Alan Cooper +9 more
openaire +4 more sources