Results 281 to 290 of about 328,822 (337)

Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post-Photothermal Therapy.

Small, 2022
Tumor antigens released from tumor cells after local photothermal therapy (PTT) can activate the tumor-specific immune responses, which are critical for eliminating the residual lesions and distant metastases.
Yao Li, Kaiyue Zhang, Yao Wu, Yale Yue, Keman Cheng, Qingqing Feng, Xiaotu Ma, Jie Liang, Nana Ma, Guangna Liu, Guangjun Nie, L. Ren, Xiao Zhao   +12 more
semanticscholar   +1 more source

Phytochemical Engineered Bacterial Outer Membrane Vesicles for Photodynamic Effects Promoted Immunotherapy.

Nano letters (Print), 2022
Cancer vaccines are emerging as an attractive modality for tumor immunotherapy. However, their practical application is seriously impeded by the complex fabrication and unsatisfactory outcomes. Herein, we construct bacterial outer membrane vesicles (OMVs)
Wanru Zhuang, Yunfeng Wang, Yao Lei, Liping Zuo, Anqi Jiang, Guanghao Wu, Weidong Nie, Lili Huang, Haiyan Xie   +8 more
semanticscholar   +1 more source

Hybrid Vesicles Based on Autologous Tumor Cell Membrane and Bacterial Outer Membrane To Enhance Innate Immune Response and Personalized Tumor Immunotherapy.

Nano letters (Print), 2021
Tumor heterogeneity, often leading to metastasis, limits the development of tumor therapy. Personalized therapy is promising to address tumor heterogeneity.
Mei‐Zhen Zou, Zi-Hao Li, Xuefeng Bai, Chuan‐Jun Liu, Xianzheng Zhang   +4 more
semanticscholar   +1 more source

Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo

Advanced Functional Materials, 2021
The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need to develop novel approaches to address the problem of antibiotic shortage, particularly for Gram‐negative ...
Shuang Wu, Y. Huang, Jiachang Yan, Yuzhen Li, Jinfeng Wang, Yi Yan Yang, Peiyan Yuan, Xin Ding   +7 more
semanticscholar   +1 more source

Host immunity and cellular responses to bacterial outer membrane vesicles.

Trends in immunology, 2021
All Gram-negative bacteria produce outer membrane vesicles (OMVs) which are minute spherical structures emanating from the bacterial outer membrane. OMVs are primarily enriched in lipopolysaccharide (LPS) and phospholipids, as well as outer membrane and ...
Varnesh Tiku, M. Tan
semanticscholar   +1 more source

Bacterial outer membrane vesicles and host cell death signaling.

Trends in Microbiology, 2021
The programmed cell death pathways of pyroptosis and apoptosis protect mammals from infections. The activation of host cell death signaling depends on cell surface and cytosolic receptors that bind bacterial molecules or sense their activity.
Subhash Dhital, P. Deo, Isabella Stuart, Thomas Naderer   +3 more
semanticscholar   +1 more source

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Advances in Materials, 2020
The highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming.
Shuang Qing, Chengliang Lyu, Li Zhu, Chao Pan, Shuang Wang, Feng Li, Jianghua Wang, H. Yue, Xiaoyong Gao, Rongrong Jia, Wei Wei, G. Ma   +11 more
semanticscholar   +1 more source

Assembly of Bacterial Outer Membrane Proteins

2012
Various methods that are routinely used to study the subcellular localization of membrane proteins in wild-type Gram-negative bacteria fall short in genetic studies addressing the biogenesis of outer membrane proteins (OMPs). Here, we describe three biochemical methods that can be used in such studies to evaluate the proper assembly of OMPs into the ...
Grijpstra, J., Bos, M.P., Tommassen, J.P.M.   +2 more
openaire   +3 more sources

Bacterial outer membrane vesicles as a platform for biomedical applications: An update.

Journal of Controlled Release, 2020
Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and contain multiple parent bacteria-derived components.
Min Li, Han Zhou, Chen Yang, Yi Wu, Xuechang Zhou, Hang Liu, Yucai Wang   +6 more
semanticscholar   +1 more source

Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor.

Cell Chemical Biology
The lysosome-targeting chimera (LYTAC) approach has shown promise for the targeted degradation of secreted and membrane proteins via lysosomes. However, there have been challenges in design, development, and targeting.
Ling-Yan Su, Yang Tian, Qiang Zheng, Yu Cao, Mengyu Yao, S. Wang, Wen Xu, Chuyu Xi, Andrea Clocchiatti, Guangjun Nie, Hejiang Zhou   +10 more
semanticscholar   +1 more source