The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria [PDF]
Nature Reviews Microbiology, 2008 Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
Jean Marie Pagès +2 more
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The Optimal Permeation of Cyclic Boronates to Cross the Outer Membrane via the Porin Pathway [PDF]
Antibiotics, 2022 We investigated the diffusion of three cyclic boronates formulated as beta-lactamase inhibitors through the porin OmpF to evaluate their potential to cross OM via the porin pathway.
Gian Marco Tuveri +3 more
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Fluoroquinolone Metalloantibiotics to Bypass Antimicrobial Resistance Mechanisms: Decreased Permeation through Porins [PDF]
Membranes, 2020 Fluoroquinolones (FQs) are broad-spectrum antibiotics largely used in the clinical practice against Gram-negative and some Gram-positive bacteria. Nevertheless, bacteria have developed several antimicrobial resistance mechanisms against such class of ...
Mariana Ferreira +2 more
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Frontiers in Microbiology, 2019 A defining characteristic of Gram-negative bacteria is the presence of an outer membrane, which functions as an additional barrier inhibiting the penetration of toxic chemicals, such as antibiotics.
Chang-Ro Lee
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Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation [PDF]
MicroorganismsPhenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular ...
Xinyue Sui +4 more
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Interplay between porin deficiency, fitness, and virulence in carbapenem-non-susceptible Pseudomonas aeruginosa and Enterobacteriaceae. [PDF]
PLoS PathogensThe increasing resistance of Gram-negative bacteria to last resort antibiotics, such as carbapenems, is particularly of concern as it is a significant cause of global health threat.
Hedi Mammeri +4 more
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Frontiers in Immunology, 2017 Several microbial components, such as bacterial DNA and flagellin, have been used as experimental vaccine adjuvants because of their inherent capacity to efficiently activate innate immune responses.
Adam F Cunningham +2 more
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Antibiotic Resistance in Klebsiella pneumoniae and Related Enterobacterales: Molecular Mechanisms, Mobile Elements, and Therapeutic Challenges [PDF]
AntibioticsDrug-resistant Klebsiella pneumoniae and related Enterobacterales represent an escalating global public health threat, increasingly limiting therapeutic options in both healthcare- and community-associated infections.
Veronika Zdarska +3 more
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The ropAe gene encodes a porin‐like protein involved in copper transit in Rhizobium etli CFN42 [PDF]
MicrobiologyOpen, 2018 Copper (Cu) is an essential micronutrient for all aerobic forms of life. Its oxidation states (Cu+/Cu2+) make this metal an important cofactor of enzymes catalyzing redox reactions in essential biological processes.
Antonio González‐Sánchez +4 more
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Understanding Drug Permeability in Pseudomonas aeruginosa [PDF]
LifePseudomonas aeruginosa is a Gram-negative bacterium that poses a serious threat to patients with weakened immunity, cystic fibrosis, severe burns, or those in hospitals.
Ishan Ghai
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