Results 1 to 10 of about 9,753 (107)
Frontiers in Microbiology, 2019 A defining characteristic of Gram-negative bacteria is the presence of an outer membrane, which functions as an additional barrier inhibiting the penetration of toxic chemicals, such as antibiotics.
Chang-Ro Lee, Umji Choi
exaly +4 more sources
Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria
Microorganisms, 2023 Gram-negative bacteria depend on their cell membranes for survival and environmental adaptation. They contain two membranes, one of which is the outer membrane (OM), which is home to several different outer membrane proteins (Omps).
Gang Zhou +8 more
doaj +2 more sources
Membrane fusion and drug delivery with carbon nanotube porins
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The plasma membrane protects cell content from the outer environment. Overcoming this obstacle and delivering drugs efficiently into cells still remain a major hurdle for modern pharmacology and medicine.
Gerhard Hummer +2 more
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Frontiers in Immunology, 2017 Several microbial components, such as bacterial DNA and flagellin, have been used as experimental vaccine adjuvants because of their inherent capacity to efficiently activate innate immune responses.
Marisol Pérez-Toledo +15 more
doaj +2 more sources
Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins
ACS Infectious Diseases, 2018 Small, hydrophilic molecules, including most important antibiotics in clinical use, cross the Gram-negative outer membrane through the water-filled channels provided by porins.
James H Naismith +2 more
exaly +2 more sources
The Influence of Permeability through Bacterial Porins in Whole-Cell Compound Accumulation
Antibiotics, 2021 The lack of new drugs for Gram-negative pathogens is a global threat to modern medicine. The complexity of their cell envelope, with an additional outer membrane, hinders internal accumulation and thus, the access of molecules to their targets.
Silvia Acosta-Gutiérrez +2 more
exaly +3 more sources
Structure, function and regulation of Pseudomonas aeruginosa porins
FEMS Microbiology Reviews, 2017 Marc G J Feuilloley +2 more
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Инфекция и иммунитет, 2022 Introduction. Study of features for interacting antigen-antibody system is of great importance for developing new modern tools for diagnostics and therapy of infectious diseases.
Ilya V. Konyshev +3 more
doaj +1 more source
How to Enter a Bacterium: Bacterial Porins and the Permeation of Antibiotics.
Chemical Reviews, 2021 Despite tremendous successes in the field of antibiotic discovery seen in the previous century, infectious diseases have remained a leading cause of death.
J. Prajapati +2 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Novel antibiotics are urgently needed to resolve the current antimicrobial resistance crisis. For critical pathogens, drug entry through the cell envelope is one of the major challenges in the development of effective novel antibiotics ...
J. Ude +10 more
semanticscholar +1 more source