Results 11 to 20 of about 12,287 (215)
On the Structure of Mitochondrial Porins and Its Homologies with Bacterial Porins
Biochemical and Biophysical Research Communications, 1994 By use of computer modelling, we have predicted a model of 16 transmembrane beta-strands for mitochondrial porins structure from human, Saccharomyces cerevisiae, Neurospora crassa and Dictyostelium discoideum. The proposed model takes into account biochemical and immunological data reported in the literature, as well as electrophysiological results ...
G Rauch, O Moran
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Solute Transport through Mitochondrial Porins In Vitro and In Vivo
BiomoleculesMitochondria are most likely descendants of strictly aerobic prokaryotes from the class Alphaproteobacteria. The mitochondrial matrix is surrounded by two membranes according to its relationship with Gram-negative bacteria. Similar to the bacterial outer
Roland Benz
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Structure and functional mechanism of porins
Physiological Reviews, 1996 Cellular organisms such as gram-negative bacteria are enclosed by a dual lipid bilayer system. The outer membranes of the dual bilayer envelopes predominantly contain large numbers of water-filled transmembrane protein channels known as porins. The recent availability of the molecular structures of several bacterial porins has provided the opportunity
B K, Jap, P J, Walian
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Porins of Borrelia burgdorferi
, 2006 Borrelia burgdorferi is a pathogenic spirochete which cycles between its arthropod vector and vertebrate host. If transmitted to humans, B. burgdorferi causes Lyme disease, an infection which can impair different organs, such as the skin, joints, nervous system and heart.
Pinne, Marija
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The role of porins in copper acquisition by mycobacteria [PDF]
International Journal of Mycobacteriology, 2015 Aims and objectives: Copper poisoning in macrophages plays an important role in immunity against invading pathogens. Many bacteria, including Mycobacterium tuberculosis (Mtb), have evolved mechanisms to combat copper-derived innate immune responses ...
Mehri Haeili +4 more
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Antimicrobial Agents and Chemotherapy, 2022 Herein, we report the in vivo evolution of imipenem/relebactam-resistance in KPC-producing K. pneumoniae (KPC-Kp) isolated from a critically-ill patient treated with multiple combination therapies based on ceftazidime-avibactam or meropenem-vaborbactam ...
P. Gaibani +5 more
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Role of internal loop dynamics in antibiotic permeability of outer membrane porins
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Antibiotic resistance in Gram-negative pathogens has been identified as an urgent threat to human health by the World Health Organization.
A. Vasan +8 more
semanticscholar +1 more source
A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance
Applied Sciences, 2023 Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment.
Ishan Ghai
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Frontiers in Immunology, 2020 Immunotherapy has improved the clinical response in melanoma patients, although a relevant percentage of patients still cannot be salvaged. The search for the immune populations that provide the best tumor control and that can be coaxed by immunotherapy ...
Ricardo A. León-Letelier +12 more
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Porins of Brucella species [PDF]
Infection and Immunity, 1984 The outer membrane of Brucella species contains two major proteins, denoted as group 2 and group 3 proteins (Verstreate et al., Infect. Immun. 35:979-989, 1982). We reconstituted proteoliposomes from the purified proteins and egg phosphatidylcholine and showed that group 2 proteins, but not a group 3 protein, had the porin activity. The influx rates of
J T, Douglas +4 more
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