Results 1 to 10 of about 65,256 (163)

Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion [PDF]

Iranian Journal of Basic Medical Sciences, 2011
Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore ...
Mohammad Ali Atlasi, Jose Luis Perez Velazquez   +1 more
doaj   +2 more sources

OmpK35/36 absence does not confer carbapenem-resistance alone nor ceftazidime-avibactam resistance with one blaKPC-2 [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveInvestigate the genetic background of porin OmpK35/36 in Klebsiella pneumoniae and their influence on antimicrobial susceptibility, particularly carbapenems and ceftazidime-avibactam (CZA).Methods1407 K.
Susu Wu, Susu Wu, Yinyin Yang, Wanyao Xiang, Jin Zhang, Jin Zhang, Xinhua Luo, Xinhua Luo, Mengqiao Xu, Dakang Hu, Dakang Hu, Dakang Hu, Haifang Zhang   +12 more
doaj   +2 more sources

Hydroxychloroquine in the treatment of adult patients with Covid-19 infection in a primary care setting (LIBERTY): A structured summary of a study protocol for a randomised controlled trial

Trials, 2021
Objectives The primary objective of this study is to evaluate the therapeutic potential of hydroxychloroquine (HCQ) in the treatment of adult patients with PCR-confirmed Covid-19 infection in a primary open-care setting, as compared to placebo. The study
Petri J. Vainio, Pauliina Hietasalo, Anna-Liisa Koivisto, Susanna Kääriäinen, Jari Turunen, Mika Virtala, Jouni Vuorinen, Mika Scheinin   +7 more
doaj   +1 more source

Differential Expression of Yersinia pseudotuberculosis General Porin Genes during Short- and Long-Term Antibiotic Stresses

Molecules, 2021
Here, we investigated general porin regulation in Yersinia pseudotuberculosis 488, the causative agent of Far Eastern scarlet-like fever, in response to sublethal concentrations of antibiotics.
Evgeniya Bystritskaya, Nadezhda Chernysheva, Anna Stenkova, Konstantin Guzev, Alexander Rakin, Marina Isaeva   +5 more
doaj   +1 more source

The Antimicrobial Resistance Characteristics of Imipenem-Non-Susceptible, Imipenemase-6-Producing Escherichia coli

Antibiotics, 2021
Imipenemase-6 (IMP-6) type carbapenemase-producing Enterobacteriaceae is regarded as dangerous due to its unique lack of antimicrobial susceptibility. It is resistant to meropenem (MEPM) but susceptible to imipenem (IPM).
Reo Onishi, Katsumi Shigemura, Kayo Osawa, Young-Min Yang, Koki Maeda, Shiuh-Bin Fang, Shian-Ying Sung, Kenichiro Onuma, Atsushi Uda, Takayuki Miyara, Masato Fujisawa   +10 more
doaj   +1 more source

Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus

Frontiers in Microbiology, 2021
Chronic pulmonary infections caused by non-tuberculous mycobacteria of the Mycobacterium abscessus complex (MABSC) are emerging as a global health problem and pose a threat to susceptible individuals with structural lung disease such as cystic fibrosis ...
Vinicius C. N. de Moura, Deepshikha Verma, Isobel Everall, Isobel Everall, Karen P. Brown, Karen P. Brown, Juan M. Belardinelli, Crystal Shanley, Megan Stapleton, Julian Parkhill, R. Andres Floto, R. Andres Floto, Diane J. Ordway, Mary Jackson   +13 more
doaj   +1 more source

Evolution of Mycobacterium abscessus in the human lung: Cumulative mutations and genomic rearrangement of porin genes in patient isolates

Virulence, 2023
Background Mycobacterium abscessus subspecies massiliense (M. massiliense) is increasingly recognized as an emerging bacterial pathogen, particularly in cystic fibrosis (CF) patients and CF centres’ respiratory outbreaks.
Shamira J. Shallom, Hervé Tettelin, Prabha Chandrasekaran, In Kwon Park, Sonia Agrawal, Kriti Arora, Lisa Sadzewicz, Aaron M. Milstone, Moira L. Aitken, Barbara A. Brown-Elliott, Richard J. Wallace, Elizabeth P. Sampaio, Michael Niederweis, Kenneth N. Olivier, Steven M. Holland, Adrian M. Zelazny   +15 more
doaj   +1 more source

Emergence of the Dickeya genus involved duplication of the OmpF porin and the adaptation of the EnvZ-OmpR signaling network

Microbiology Spectrum, 2023
Genome evolution, and more specifically gene duplication, is a key process shaping host–microorganism interaction. The conserved paralogs usually provide an advantage to the bacterium to thrive. If not, these genes become pseudogenes and disappear. Here,
Clémence Cochard, Marine Caby, Peggy Gruau, Edwige Madec, Michael Marceau, Iulia Macavei, Jérôme Lemoine, Chrystelle Le Danvic, Franck Bouchart, Brigitte Delrue, Sébastien Bontemps-Gallo, Jean-Marie Lacroix   +11 more
doaj   +1 more source

Opettajan asiantuntijuus muutoksessa – asiantuntijuus ja sen jakamisen diskurssit digitaalisessa oppimisympäristössä

Kasvatus & Aika, 2019
Asiantuntijuus ja asiantuntijatyö on perinteisesti liitetty spesifeihin ammattialoihin ja professionaalisuuteen. Teknologian lisääntyvä käyttö asiantuntijatyössä kuitenkin muuttaa asiantuntijuuden ilmenemistä ja sen rajoja. Tässä artikkelissa tarkastelen
Jenni Huhtasalo
doaj   +1 more source

Porin from Marine Bacterium Marinomonas primoryensis KMM 3633^T: Isolation, Physico-Chemical Properties, and Functional Activity

Molecules, 2020
Marinomonas primoryensis KMM 3633T, extreme living marine bacterium was isolated from a sample of coastal sea ice in the Amursky Bay near Vladivostok, Russia. The goal of our investigation is to study outer membrane channels determining cell permeability.
Olga D. Novikova, Valentina A. Khomenko, Natalia Yu. Kim, Galina N. Likhatskaya, Lyudmila A. Romanenko, Ekaterina I. Aksenova, Marina S. Kunda, Natalia N. Ryzhova, Olga Yu. Portnyagina, Tamara F. Solov’eva, Olga L. Voronina   +10 more
doaj   +1 more source