Results 1 to 10 of about 13,527 (142)
Involvement of SIRT3 downstream targets ANT1, VDAC, CYPD, and Drp1 in a rat model of hepatic encephalopathy: Therapeutic role of thymoquinone [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Hepatic encephalopathy (HE) is a brain disorder linked to hyperammonemia from liver injury. Elevated ammonia levels are known to impair mitochondrial function, the primary energy source for cells.
Somayeh Hajipour +4 more
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Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology [PDF]
Frontiers in PhysiologyThe present paper is a review of the mitochondrial Voltage Dependent Anion Channel (VDAC), popularly known as mitochondrial porin, which is a protein that forms a passive diffusion ion channel across the outer membrane of the mitochondrion.
Daniel Tuikhang Koren +4 more
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Сибирский онкологический журнал, 2022 Purpose to study the tumor-forming activity of wild-type MC F-7 cells carrying a full set of porins (VDAC 1, VDAC 2, VDAC 3), as well as their genetically modified cells, from which one of the isoforms was removed (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO, MC ...
E. Yu. Mndlyan +8 more
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The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease
Cells, 2021 The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion selective state, and a closed and slightly cation-selective state.
Joyce T. Varughese +2 more
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Frontiers in Physiology, 2021 Voltage-dependent anion-selective channel (VDAC) allows the exchange of small metabolites and inorganic ions across the mitochondrial outer membrane. It is involved in complex interactions that regulate mitochondrial and cellular functioning.
Andonis Karachitos +3 more
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In Silico Exploration of Alternative Conformational States of VDAC
Molecules, 2023 VDAC (Voltage-Dependent Anion-selective Channel) is the primary metabolite pore in the mitochondrial outer membrane (OM). Atomic structures of VDAC, consistent with its physiological “open” state, are β-barrels formed by 19 transmembrane (TM) β-strands ...
Carmen Mannella
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Frontiers in Physiology, 2021 The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Previously,
Fraser G. Ferens +5 more
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The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration
Frontiers in Physiology, 2021 Voltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore.
Anasuya Moitra, Doron Rapaport
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VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges
Frontiers in Physiology, 2021 Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage ...
Kareem A. Heslop +3 more
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VDAC Genes Expression and Regulation in Mammals
Frontiers in Physiology, 2021 VDACs are pore-forming proteins, coating the mitochondrial outer membrane, and playing the role of main regulators for metabolites exchange between cytosol and mitochondria. In mammals, three isoforms have evolutionary originated, VDAC1, VDAC2, and VDAC3.
Federica Zinghirino +10 more
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