Results 1 to 10 of about 14,744 (224)
In Silico Exploration of Alternative Conformational States of VDAC
Molecules, 2023 VDAC (Voltage-Dependent Anion-selective Channel) is the primary metabolite pore in the mitochondrial outer membrane (OM). Atomic structures of VDAC, consistent with its physiological “open” state, are β-barrels formed by 19 transmembrane (TM) β-strands ...
Carmen Mannella
doaj +2 more sources
VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges [PDF]
Frontiers in Physiology, 2021 Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage ...
Kareem A. Heslop +3 more
doaj +2 more sources
Membrane lipid composition modulates the organization of VDAC1, a mitochondrial gatekeeper [PDF]
Communications BiologyVDACs, the most abundant proteins in the outer mitochondrial membrane (MOM), are crucial for mitochondrial physiology. VDAC regulate metabolite and ion exchange, modulate calcium homeostasis, and play roles in numerous cellular events such as apoptosis ...
Elodie Lafargue +8 more
doaj +2 more sources
Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology [PDF]
Frontiers in PhysiologyThe present paper is a review of the mitochondrial Voltage Dependent Anion Channel (VDAC), popularly known as mitochondrial porin, which is a protein that forms a passive diffusion ion channel across the outer membrane of the mitochondrion.
Daniel Tuikhang Koren +4 more
doaj +2 more sources
Single scores in the RT-based value-driven attentional capture paradigm have high reliability [PDF]
Scientific ReportsValue-driven attentional capture (VDAC) involves involuntary attention shifts towards neutral stimuli previously associated with rewards. This phenomenon is pertinent for various neuropsychiatric conditions. This study aims to evaluate the reliability of
Chung-Yi Shih +2 more
doaj +2 more sources
Сибирский онкологический журнал, 2022 Purpose to study the tumor-forming activity of wild-type MC F-7 cells carrying a full set of porins (VDAC 1, VDAC 2, VDAC 3), as well as their genetically modified cells, from which one of the isoforms was removed (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO, MC ...
E. Yu. Mndlyan +8 more
doaj +1 more source
The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease
Cells, 2021 The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion selective state, and a closed and slightly cation-selective state.
Joyce T. Varughese +2 more
doaj +1 more source
Frontiers in Physiology, 2021 Voltage-dependent anion-selective channel (VDAC) allows the exchange of small metabolites and inorganic ions across the mitochondrial outer membrane. It is involved in complex interactions that regulate mitochondrial and cellular functioning.
Andonis Karachitos +3 more
doaj +1 more source
Frontiers in Physiology, 2021 The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Previously,
Fraser G. Ferens +5 more
doaj +1 more source
The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration
Frontiers in Physiology, 2021 Voltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore.
Anasuya Moitra, Doron Rapaport
doaj +1 more source