The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease
Cells, 2021 The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion selective state, and a closed and slightly cation-selective state.
Joyce T. Varughese +2 more
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Ten Years of High Resolution Structural Research on the Voltage Dependent Anion Channel (VDAC)—Recent Developments and Future Directions [PDF]
Frontiers in Physiology, 2018 Mitochondria are evolutionarily related to Gram-negative bacteria and both comprise two membrane systems with strongly differing protein composition. The major protein in the outer membrane of mitochondria is the voltage-dependent anion channel (VDAC ...
Kornelius Zeth +2 more
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Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology [PDF]
Frontiers in PhysiologyThe present paper is a review of the mitochondrial Voltage Dependent Anion Channel (VDAC), popularly known as mitochondrial porin, which is a protein that forms a passive diffusion ion channel across the outer membrane of the mitochondrion.
Daniel Tuikhang Koren +4 more
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Orientia tsutsugamushi Alters Mitochondrial Function and Selectively Associates with VDAC [PDF]
PathogensOrientia tsutsugamushi is an obligate intracellular alphaproteobacterium and the causative agent of the potentially fatal rickettsiosis, scrub typhus. During infection, O.
Savannah E. Sanchez +4 more
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Current state of theoretical and experimental studies of the voltage-dependent anion channel (VDAC). [PDF]
Biochim Biophys Acta, 2016 Noskov SY +5 more
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Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. [PDF]
PLoS ONE, 2011 The voltage-dependent anion channel (VDAC) forms the major pore in the outer mitochondrial membrane. Its high conducting open state features a moderate anion selectivity.
Eva-Maria Krammer +2 more
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Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
Biomolecules, 2021 Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions.
Pierpaolo Risiglione +4 more
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Frontiers in Physiology, 2021 The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Previously,
Fraser G. Ferens +5 more
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The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration
Frontiers in Physiology, 2021 Voltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore.
Anasuya Moitra, Doron Rapaport
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Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability
Saudi Pharmaceutical Journal, 2020 Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing.
Karolina Cierluk +6 more
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