The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease
Cells, 2021 The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion selective state, and a closed and slightly cation-selective state.
Joyce T. Varughese +2 more
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Ten Years of High Resolution Structural Research on the Voltage Dependent Anion Channel (VDAC)—Recent Developments and Future Directions [PDF]
Frontiers in Physiology, 2018 Mitochondria are evolutionarily related to Gram-negative bacteria and both comprise two membrane systems with strongly differing protein composition. The major protein in the outer membrane of mitochondria is the voltage-dependent anion channel (VDAC ...
Kornelius Zeth +2 more
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Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology [PDF]
Frontiers in PhysiologyThe present paper is a review of the mitochondrial Voltage Dependent Anion Channel (VDAC), popularly known as mitochondrial porin, which is a protein that forms a passive diffusion ion channel across the outer membrane of the mitochondrion.
Daniel Tuikhang Koren +4 more
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Elliptical β-barrel deformation underlies gating in VDAC1. [PDF]
Protein SciAbstract Gating by voltage‐dependent anion channels (VDAC) regulates mitochondrial metabolite flux, yet the structural mechanism underlying the open‐to‐closed transition remains unresolved. Here, we combine atomistic molecular dynamics (MD) simulations with double electron–electron resonance (DEER), using hydrostatic pressure as a reversible ...
Bergdoll L +6 more
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Genome-Wide Characterization of VDAC Gene Family in Soybean (Glycine max L.) and In Silico Expression Profiling in Response to Drought and Salt Stress [PDF]
PlantsSoybean (Glycine max L.) is grown worldwide to obtain edible oil, livestock feed, and biodiesel. However, drought and salt stress are becoming serious challenges to global soybean cultivation as they retard the growth of soybean plants and cause ...
Muhammad Muneeb Ullah +4 more
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Orientia tsutsugamushi Alters Mitochondrial Function and Selectively Associates with VDAC [PDF]
PathogensOrientia tsutsugamushi is an obligate intracellular alphaproteobacterium and the causative agent of the potentially fatal rickettsiosis, scrub typhus. During infection, O.
Savannah E. Sanchez +4 more
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Structural basis of apoptosis induction by the mitochondrial voltage-dependent anion channel [PDF]
Nature CommunicationsThe voltage-dependent anion channel (VDAC) is the main gateway for metabolites across the mitochondrial outer membrane. VDAC oligomers are connected to apoptosis induced by various stimuli.
Melina Daniilidis +8 more
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Current state of theoretical and experimental studies of the voltage-dependent anion channel (VDAC). [PDF]
Biochim Biophys Acta, 2016 Noskov SY +5 more
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Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. [PDF]
PLoS ONE, 2011 The voltage-dependent anion channel (VDAC) forms the major pore in the outer mitochondrial membrane. Its high conducting open state features a moderate anion selectivity.
Eva-Maria Krammer +2 more
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Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
Biomolecules, 2021 Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions.
Pierpaolo Risiglione +4 more
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