Frontiers in Oncology, 2017 The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as ...
John J. Lemasters, John J. Lemasters
doaj +1 more source
Markov chain Monte Carlo based analysis of post-translationally modified VDAC1 gating kinetics
Frontiers in Physiology, 2015 The voltage-dependent anion channel (VDAC) is the main conduit for permeation of solutes (including nucleotides and metabolites) of up to 5 kDa across the mitochondrial outer membrane (MOM). Recent studies suggest that VDAC activity is regulated via post-
Shivendra eTewari +5 more
doaj +1 more source
Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease
Cells, 2019 In recent decades, there have been several models describing the relationships between the cytoskeleton and the bioenergetic function of the cell. The main player in these models is the voltage-dependent anion channel (VDAC), located in the mitochondrial
Marju Puurand +6 more
doaj +1 more source
Precocene II, a Trichothecene Production Inhibitor, Binds to Voltage-Dependent Anion Channel and Increases the Superoxide Level in Mitochondria of Fusarium graminearum. [PDF]
PLoS ONE, 2015 Precocene II, a constituent of essential oils, shows antijuvenile hormone activity in insects and inhibits trichothecene production in fungi. We investigated the molecular mechanism by which precocene II inhibits trichothecene production in Fusarium ...
Tomohiro Furukawa +5 more
doaj +1 more source
Decrypting strong and weak single-walled carbon nanotubes interactions with mitochondrial voltage-dependent anion channels using molecular docking and perturbation theory [PDF]
, 2017 [Abstract] The current molecular docking study provided the Free Energy of Binding (FEB) for the interaction (nanotoxicity) between VDAC mitochondrial channels of three species (VDAC1-Mus musculus, VDAC1-Homo sapiens, VDAC2-Danio rerio) with SWCNT-H ...
González-Durruthy, Michael +7 more
core +3 more sources
Voltage Dependent Anion Channels (VDAC) and Regulation of Mitochondrial Metabolism [PDF]
Biophysical Journal, 2015 Voltage dependent anion channels (VDAC) are responsible for permeability of mitochondrial outer membranes to hydrophilic metabolites like ATP, ADP and respiratory substrates. Although previously assumed to remain open, VDAC closure is emerging as an important mechanism for regulation of global mitochondrial function. Acetaldehyde formation from hepatic
openaire +1 more source
Identification and Characterization of VDAC Family in Maize
Plants, 2023 The voltage-dependent anion channel (VDAC) is the most abundant protein in the outer mitochondrial membrane (OMM) of all eukaryotes, having an important role in the communication between mitochondria and cytosol.
Carolina Rodríguez-Saavedra +6 more
doaj +1 more source
VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications [PDF]
, 2016 Voltage-Dependent Anion selective Channels (VDAC) are pore-forming mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized isoform, presents a set of cysteines predicted to be exposed toward the intermembrane space.
Ceccarelli, M +14 more
core +5 more sources
Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease [PDF]
, 2010 Perturbed neuronal calcium homeostasis is a prominent feature in Alzheimer's disease (AD). Mitochondria accumulate calcium ions (Ca2+) for cellular bioenergetic metabolism and suppression of mitochondrial motility within the cell.
Chang, RCC, Ho, YS, Hung, CHL
core +1 more source
Peran Vdac (Voltage Dependent Anion Channel) Terhadap Fungsi Spermatozoa
JURNAL KESEHATAN BHAKTI HUSADA, 2021 Sperma berkualitas baik dibutuhkan untuk keberhasilan proses fertilisasi. Untuk dapat membuahi sel telur, sperma mengalami perubahan-perubahan yang bersifat biokimia maupun biofisik, yaitu proses kapasitasi dan reaksi akrosom. Selain itu sperma harus mempunyai kemampuan gerak yang progresif untuk dapat mencapai sel telur.
openaire +1 more source