Results 41 to 50 of about 9,496 (202)

Voltage Dependent Anion Channels (VDAC) and Regulation of Mitochondrial Metabolism [PDF]

Biophysical Journal, 2015
Voltage dependent anion channels (VDAC) are responsible for permeability of mitochondrial outer membranes to hydrophilic metabolites like ATP, ADP and respiratory substrates. Although previously assumed to remain open, VDAC closure is emerging as an important mechanism for regulation of global mitochondrial function. Acetaldehyde formation from hepatic
openaire   +1 more source

Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior

, 2012
Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang, Anastasia Salisowski, Koert, Ulrich, Reiss, Philipp, Ulrich Koert (125542), Georgios Psakis (125535), Katrin Christiane Back, Philipp Reiss, Mertins, Barbara, Lars-Oliver Essen (125543), Wolfgang Grosse (125537), Back, Katrin Christiane, Anastasia Salisowski (125540), Essen, Lars-Oliver, Barbara Mertins, Wolfgang Grosse, Psakis, Georgios, Barbara Mertins (125533), Philipp Reiss (125541), Lars-Oliver Essen, Georgios Psakis, Katrin Christiane Back (125538), Salisowski, Anastasia, Ulrich Koert   +23 more
core   +1 more source

Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease

Cells, 2019
In recent decades, there have been several models describing the relationships between the cytoskeleton and the bioenergetic function of the cell. The main player in these models is the voltage-dependent anion channel (VDAC), located in the mitochondrial
Marju Puurand, Kersti Tepp, Natalja Timohhina, Jekaterina Aid, Igor Shevchuk, Vladimir Chekulayev, Tuuli Kaambre   +6 more
doaj   +1 more source

Precocene II, a Trichothecene Production Inhibitor, Binds to Voltage-Dependent Anion Channel and Increases the Superoxide Level in Mitochondria of Fusarium graminearum. [PDF]

PLoS ONE, 2015
Precocene II, a constituent of essential oils, shows antijuvenile hormone activity in insects and inhibits trichothecene production in fungi. We investigated the molecular mechanism by which precocene II inhibits trichothecene production in Fusarium ...
Tomohiro Furukawa, Naoko Sakamoto, Michio Suzuki, Makoto Kimura, Hiromichi Nagasawa, Shohei Sakuda   +5 more
doaj   +1 more source

Identification and Characterization of VDAC Family in Maize

Plants, 2023
The voltage-dependent anion channel (VDAC) is the most abundant protein in the outer mitochondrial membrane (OMM) of all eukaryotes, having an important role in the communication between mitochondria and cytosol.
Carolina Rodríguez-Saavedra, Donají Azucena García-Ortiz, Andrés Burgos-Palacios, Luis Enrique Morgado-Martínez, Beatriz King-Díaz, Ángel Arturo Guevara-García, Sobeida Sánchez-Nieto   +6 more
doaj   +1 more source

Deterministic Model of the Voltage Dependent Anion Channel (VDAC) Kinetics

, 2020
The voltage-dependent anion channel (VDAC) is a voltage gated channel residing on the outer mitochondrial membrane (OMM) that facilitates the flow of metabolites between the cytosol and mitochondria.
Shah, Viren
core   +1 more source

Peran Vdac (Voltage Dependent Anion Channel) Terhadap Fungsi Spermatozoa

JURNAL KESEHATAN BHAKTI HUSADA, 2021
Sperma berkualitas baik dibutuhkan untuk keberhasilan proses fertilisasi. Untuk dapat membuahi sel telur, sperma mengalami perubahan-perubahan yang bersifat biokimia maupun biofisik, yaitu proses kapasitasi dan reaksi akrosom. Selain itu sperma harus mempunyai kemampuan gerak yang progresif untuk dapat mencapai sel telur.
openaire   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source