Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase
Nature Communications, 2023 Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this is unclear.
Helene Jahn +6 more
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The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. [PDF]
PLoS ONE, 2014 BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway. We reported previously that mitochondrial localization of BNIP3 and translocation of EndoG from mitochondria to the nucleus are critical steps of the BNIP3 ...
Xiaosha Zhang, Xiuwu Bian, Jiming Kong
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Characterizing ATP Permeation through the Voltage-Dependent Anion Channel VDAC [PDF]
Biophysical Journal, 2014 Voltage-dependent anion channels (VDAC) mediate the transfer of metabolites such as ATP, ADP, and NADH across the outer mitochondrial membrane of all eukaryotic cells. The open state is selective for anions, while the partially closed state is selective for cations. The x-ray crystal structure of VDAC from mouse (mVDAC1) (Ujwal et al.
Choudhary, Om P. +5 more
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Frontiers in Oncology, 2017 The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as ...
John J. Lemasters, John J. Lemasters
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Markov chain Monte Carlo based analysis of post-translationally modified VDAC1 gating kinetics
Frontiers in Physiology, 2015 The voltage-dependent anion channel (VDAC) is the main conduit for permeation of solutes (including nucleotides and metabolites) of up to 5 kDa across the mitochondrial outer membrane (MOM). Recent studies suggest that VDAC activity is regulated via post-
Shivendra eTewari +5 more
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Voltage Dependent Anion Channels (VDAC) and Regulation of Mitochondrial Metabolism [PDF]
Biophysical Journal, 2015 Voltage dependent anion channels (VDAC) are responsible for permeability of mitochondrial outer membranes to hydrophilic metabolites like ATP, ADP and respiratory substrates. Although previously assumed to remain open, VDAC closure is emerging as an important mechanism for regulation of global mitochondrial function. Acetaldehyde formation from hepatic
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Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease
Cells, 2019 In recent decades, there have been several models describing the relationships between the cytoskeleton and the bioenergetic function of the cell. The main player in these models is the voltage-dependent anion channel (VDAC), located in the mitochondrial
Marju Puurand +6 more
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Precocene II, a Trichothecene Production Inhibitor, Binds to Voltage-Dependent Anion Channel and Increases the Superoxide Level in Mitochondria of Fusarium graminearum. [PDF]
PLoS ONE, 2015 Precocene II, a constituent of essential oils, shows antijuvenile hormone activity in insects and inhibits trichothecene production in fungi. We investigated the molecular mechanism by which precocene II inhibits trichothecene production in Fusarium ...
Tomohiro Furukawa +5 more
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Identification and Characterization of VDAC Family in Maize
Plants, 2023 The voltage-dependent anion channel (VDAC) is the most abundant protein in the outer mitochondrial membrane (OMM) of all eukaryotes, having an important role in the communication between mitochondria and cytosol.
Carolina Rodríguez-Saavedra +6 more
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Peran Vdac (Voltage Dependent Anion Channel) Terhadap Fungsi Spermatozoa
JURNAL KESEHATAN BHAKTI HUSADA, 2021 Sperma berkualitas baik dibutuhkan untuk keberhasilan proses fertilisasi. Untuk dapat membuahi sel telur, sperma mengalami perubahan-perubahan yang bersifat biokimia maupun biofisik, yaitu proses kapasitasi dan reaksi akrosom. Selain itu sperma harus mempunyai kemampuan gerak yang progresif untuk dapat mencapai sel telur.
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