Results 31 to 40 of about 9,496 (202)
Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility
Cellular Physiology and Biochemistry, 2014 Background: Voltage-dependent anion channel (VDAC), a channel protein, exists in the outer mitochondrial membrane of somatic cells and is involved in multiple physiological and pathophysiological processes.
Bianjiang Liu +9 more
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Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target [PDF]
Cancer Biology & Therapy, 2010 Commentary to:Down-regulation of voltage-dependent anion channel-1 expression by RNA interference prevents cancer cell growth in vivoInbar Koren, Ziv Raviv and Varda Shoshan ...
Saroj P, Mathupala, Peter L, Pedersen
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Frontiers in Oncology, 2021 Metabolic plasticity is the ability of the cell to adjust its metabolism to changes in environmental conditions. Increased metabolic plasticity is a defining characteristic of cancer cells, which gives them the advantage of survival and a higher ...
Leenu Reinsalu +12 more
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Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. [PDF]
PLoS ONE, 2016 We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cancer cell
Haizhong Huo +5 more
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Cell-free electrophysiology of human VDACs incorporated into nanodiscs: An improved method
Biophysical Reports, 2021 Voltage-dependent anion-selective channel (VDAC) is one of the main proteins of the outer mitochondrial membrane of all eukaryotes, where it forms aqueous, voltage-sensitive, and ion-selective channels.
Stefano Conti Nibali +5 more
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Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase
Nature Communications, 2023 Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this is unclear.
Helene Jahn +6 more
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The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. [PDF]
PLoS ONE, 2014 BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway. We reported previously that mitochondrial localization of BNIP3 and translocation of EndoG from mitochondria to the nucleus are critical steps of the BNIP3 ...
Xiaosha Zhang, Xiuwu Bian, Jiming Kong
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Characterizing ATP Permeation through the Voltage-Dependent Anion Channel VDAC [PDF]
Biophysical Journal, 2014 Voltage-dependent anion channels (VDAC) mediate the transfer of metabolites such as ATP, ADP, and NADH across the outer mitochondrial membrane of all eukaryotic cells. The open state is selective for anions, while the partially closed state is selective for cations. The x-ray crystal structure of VDAC from mouse (mVDAC1) (Ujwal et al.
Choudhary, Om P. +5 more
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Frontiers in Oncology, 2017 The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as ...
John J. Lemasters, John J. Lemasters
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Markov chain Monte Carlo based analysis of post-translationally modified VDAC1 gating kinetics
Frontiers in Physiology, 2015 The voltage-dependent anion channel (VDAC) is the main conduit for permeation of solutes (including nucleotides and metabolites) of up to 5 kDa across the mitochondrial outer membrane (MOM). Recent studies suggest that VDAC activity is regulated via post-
Shivendra eTewari +5 more
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