Results 11 to 20 of about 9,496 (202)

The intrinsically disordered N-terminus of the voltage-dependent anion channel.

PLoS Computational Biology, 2021
The voltage-dependent anion channel (VDAC) is a critical β-barrel membrane protein of the mitochondrial outer membrane, which regulates the transport of ions and ATP between mitochondria and the cytoplasm.
Jordane Preto, Isabelle Krimm
doaj   +2 more sources

Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation

BMC Medical Genetics, 2009
Background The mitochondrial voltage-dependent anion channel (VDAC) is increasingly implicated in the control of apoptosis. We have studied the effects the mitochondrial DNA (mtDNA) tRNAIle mutation on VDAC expression, localization, and apoptosis ...
Mohan Liu, Rui Chen, Lin Wang, Hua Xu, Zongbin Li, Yang Li, Lei Gao, Yuqi Liu, Yi Wen, Minxin Guan, Shiwen Wang   +10 more
doaj   +2 more sources

Involvement of voltage-dependent anion channel (VDAC) in dengue infection. [PDF]

Sci Rep, 2016
AbstractDuring infection, dengue virus (DENV) proteins interact with host cellular constituents promoting the remodeling of the cell to facilitate virus production. While a number of interacting proteins have been identified for DENV non-structural proteins, far fewer interacting partners have been identified for the DENV structural proteins.
Jitobaom K, Tongluan N, Smith DR.
europepmc   +4 more sources

Structural basis of the mitochondrial voltage-dependent anion channel VDAC I [PDF]

, 2008
Meins, Thomas, Meins, T.
openaire   +3 more sources

A C-Terminally Truncated Variant of Neurospora crassa VDAC Assembles Into a Partially Functional Form in the Mitochondrial Outer Membrane and Forms Multimers in vitro

Frontiers in Physiology, 2021
The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Previously,
Fraser G. Ferens, Fraser G. Ferens, William A. T. Summers, Ameet Bharaj, Jörg Stetefeld, Deborah A. Court   +5 more
doaj   +1 more source

Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC). [PDF]

Sci Rep, 2017
AbstractAspirin induces apoptotic cell death in various cancer cell lines. Here we showed that silencing of VDAC1 protected HeLa cells from aspirin-induced cell death. Compared to the wild type cells, VDAC1 knocked down cells showed lesser change of mitochondrial membrane potential (Δψm), upon aspirin treatment.
Tewari D, Majumdar D, Vallabhaneni S, Bera AK.   +3 more
europepmc   +3 more sources

Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Saudi Pharmaceutical Journal, 2020
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing.
Karolina Cierluk, Wojciech Szlasa, Joanna Rossowska, Mounir Tarek, Anna Szewczyk, Jolanta Saczko, Julita Kulbacka   +6 more
doaj   +1 more source

Redox-Sensitive VDAC: A Possible Function as an Environmental Stress Sensor Revealed by Bioinformatic Analysis

Frontiers in Physiology, 2021
Voltage-dependent anion-selective channel (VDAC) allows the exchange of small metabolites and inorganic ions across the mitochondrial outer membrane. It is involved in complex interactions that regulate mitochondrial and cellular functioning.
Andonis Karachitos, Wojciech Grabiński, Martyna Baranek, Hanna Kmita   +3 more
doaj   +1 more source

The Single Residue K12 Governs the Exceptional Voltage Sensitivity of Mitochondrial Voltage-Dependent Anion Channel Gating

, 2022
International audienceThe voltage-dependent anion channel (VDAC) is a βbarrel channel of the mitochondrial outer membrane (MOM) that passively transports ions, metabolites, polypeptides, and single-stranded DNA. VDAC responds to a transmembrane potential
Rostovtseva, Tatiana, K, Queralt-Martín, María, Hoogerheide, David, P, Khan, Farha, Bezrukov, Sergey m., Bergdoll, Lucie, Abramson, Jeff, Noskov, Sergei, Yu, Ngo, Van, A.   +8 more
core   +5 more sources

Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs

Frontiers in Physiology, 2020
There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC).
Tatiana K. Rostovtseva, María Queralt-Martín, William M. Rosencrans, Sergey M. Bezrukov   +3 more
doaj   +1 more source