Results 41 to 50 of about 14,744 (224)

Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis

Frontiers in Oncology, 2017
The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as ...
John J. Lemasters, John J. Lemasters
doaj   +1 more source

The intrinsically disordered N-terminus of the voltage-dependent anion channel.

PLoS Computational Biology, 2021
The voltage-dependent anion channel (VDAC) is a critical β-barrel membrane protein of the mitochondrial outer membrane, which regulates the transport of ions and ATP between mitochondria and the cytoplasm.
Jordane Preto, Isabelle Krimm
doaj   +1 more source

VDAC-1 over-expression potentiates erastin’s cytotoxicity.

, 2016
Stably HT-29 cells or NCM460 colon epithelial cells expressing empty vector (pSuper-puro, “Vec”) or VDAC-1 cDNA (“VDAC-1”) were treated with designed erastin for applied time, VDAC-1 expression, cell survival and apoptosis were tested by Western blotting
Zhiyuan Zhou (350818), Haizhong Huo (3171984), Wenyong Liu (1510897), Jian Qin (34092), Bing Wang (126120), Yan Gu (125500)   +5 more
core   +1 more source

VDAC in cancer

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017
The voltage-dependent anion channel (VDAC) is a pore located at the outer membrane of the mitochondrion. It allows the entry and exit of numerous ions and metabolites between the cytosol and the mitochondrion. Flux through the pore occurs in an active way: first, it depends on the open or closed state and second, on the negative or positive charges of ...
openaire   +2 more sources

Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior

, 2012
Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang, Anastasia Salisowski, Koert, Ulrich, Reiss, Philipp, Ulrich Koert (125542), Georgios Psakis (125535), Katrin Christiane Back, Philipp Reiss, Mertins, Barbara, Lars-Oliver Essen (125543), Wolfgang Grosse (125537), Back, Katrin Christiane, Anastasia Salisowski (125540), Essen, Lars-Oliver, Barbara Mertins, Wolfgang Grosse, Psakis, Georgios, Barbara Mertins (125533), Philipp Reiss (125541), Lars-Oliver Essen, Georgios Psakis, Katrin Christiane Back (125538), Salisowski, Anastasia, Ulrich Koert   +23 more
core   +1 more source

Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation

BMC Medical Genetics, 2009
Background The mitochondrial voltage-dependent anion channel (VDAC) is increasingly implicated in the control of apoptosis. We have studied the effects the mitochondrial DNA (mtDNA) tRNAIle mutation on VDAC expression, localization, and apoptosis ...
Mohan Liu, Rui Chen, Lin Wang, Hua Xu, Zongbin Li, Yang Li, Lei Gao, Yuqi Liu, Yi Wen, Minxin Guan, Shiwen Wang   +10 more
doaj   +1 more source

Dual mechanism of ion permeation through VDAC revealed with inorganic phosphate ions and phosphate metabolites. [PDF]

PLoS ONE, 2015
In the exchange of metabolites and ions between the mitochondrion and the cytosol, the voltage-dependent anion channel (VDAC) is a key element, as it forms the major transport pathway for these compounds through the mitochondrial outer membrane. Numerous
Eva-Maria Krammer, Giang Thi Vu, Fabrice Homblé, Martine Prévost   +3 more
doaj   +1 more source

Energy Metabolic Plasticity of Colorectal Cancer Cells as a Determinant of Tumor Growth and Metastasis

Frontiers in Oncology, 2021
Metabolic plasticity is the ability of the cell to adjust its metabolism to changes in environmental conditions. Increased metabolic plasticity is a defining characteristic of cancer cells, which gives them the advantage of survival and a higher ...
Leenu Reinsalu, Leenu Reinsalu, Marju Puurand, Vladimir Chekulayev, Sten Miller, Sten Miller, Igor Shevchuk, Kersti Tepp, Egle Rebane-Klemm, Egle Rebane-Klemm, Natalja Timohhina, Anton Terasmaa, Tuuli Kaambre   +12 more
doaj   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Is huntingtin a modulator of VDAC?

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
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Karachitos A, Stobienia O, Jordan J, DE PINTO, Vito Nicola, Kmita H.   +4 more
openaire   +3 more sources