Results 21 to 30 of about 15,633 (213)

The Electrostatics of VDAC: Implications for Selectivity and Gating [PDF]

Journal of Molecular Biology, 2010
The voltage-dependent anion channel (VDAC) is the major pathway mediating the transfer of metabolites and ions across the mitochondrial outer membrane. Two hallmarks of the channel in the open state are high metabolite flux and anion selectivity, while the partially closed state blocks metabolites and is cation selective.
Choudhary, Om P., Ujwal, Rachna, Kowallis, William, Coalson, Rob, Abramson, Jeff, Grabe, Michael   +5 more
openaire   +3 more sources

VDAC regulates AAC-mediated apoptosis and cytochrome c release in yeast [PDF]

, 2016
Mitochondrial outer membrane permeabilization is a key event in apoptosis processes leading to the release of lethal factors. We have previously shown that absence of the ADP/ATP carrier (AAC) proteins (yeast orthologues of mammalian ANT proteins ...
Côrte-Real, Manuela, Dário Trindade, Maria João Sousa, Sousa, Maria João, Manon, Stephen, Pereira, Clara Isabel Ferreira, Susana R. Chaves, Chaves, Susana Alexandra Rodrigues, Clara Pereira, Stéphen Manon, Manuela Côrte-Real, Trindade, Dario Alexandre Martins   +11 more
core   +1 more source

VDAC, The early days

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
VDAC is now universally accepted as the channel in the mitochondrial outer membrane responsible for metabolite flux in and out of mitochondria. Its discovery occurred over two independent lines of investigation in the 1970s and 80s. This retrospective article describes the history of VDAC's discovery and how these lines merged in a collaboration by the
Colombini, Marco, Mannella, Carmen A.
openaire   +2 more sources

Using VDAC-Tubulin Interaction to Assess VDAC Orientation in the Mitochondrial Membrane [PDF]

Biophysical Journal, 2010
Recently we have found that dimeric αβ-tubulin at nanomolar concentrations induces reversible partial blockage of VDAC channel, reconstituted into a planar lipid membrane (Rostovtseva et al., PNAS 2008). Tubulin induces characteristic, well resolved fast blocking events with the highly voltage-dependent binding parameters. Tubulin interaction with VDAC
Rostovtseva, Tatiana K., Sheldon, Kely, Bezrukov, Sergey M.   +2 more
openaire   +1 more source

Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. [PDF]

PLoS ONE, 2011
Tubulin was recently found to be a uniquely potent regulator of the voltage-dependent anion channel (VDAC), the most abundant channel of the mitochondrial outer membrane, which constitutes a major pathway for ATP/ADP and other metabolites across this ...
Kely L Sheldon, Eduardo N Maldonado, John J Lemasters, Tatiana K Rostovtseva, Sergey M Bezrukov   +4 more
doaj   +1 more source

Markov chain Monte Carlo based analysis of post-translationally modified VDAC1 gating kinetics

Frontiers in Physiology, 2015
The voltage-dependent anion channel (VDAC) is the main conduit for permeation of solutes (including nucleotides and metabolites) of up to 5 kDa across the mitochondrial outer membrane (MOM). Recent studies suggest that VDAC activity is regulated via post-
Shivendra eTewari, Yifan eZhou, Bradley eOtto, Ranjan K. Dash, Wai-Meng eKwok, Daniel eBeard   +5 more
doaj   +1 more source

Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. [PDF]

PLoS ONE, 2011
The voltage-dependent anion channel (VDAC) forms the major pore in the outer mitochondrial membrane. Its high conducting open state features a moderate anion selectivity.
Eva-Maria Krammer, Fabrice Homblé, Martine Prévost   +2 more
doaj   +1 more source

Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior [PDF]

, 2012
Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang, Anastasia Salisowski, Koert, Ulrich, Reiss, Philipp, Ulrich Koert (125542), Georgios Psakis (125535), Katrin Christiane Back, Philipp Reiss, Mertins, Barbara, Lars-Oliver Essen (125543), Wolfgang Grosse (125537), Back, Katrin Christiane, Anastasia Salisowski (125540), Essen, Lars-Oliver, Barbara Mertins, Wolfgang Grosse, Psakis, Georgios, Barbara Mertins (125533), Philipp Reiss (125541), Lars-Oliver Essen, Georgios Psakis, Katrin Christiane Back (125538), Salisowski, Anastasia, Ulrich Koert   +23 more
core   +2 more sources

Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility

Cellular Physiology and Biochemistry, 2014
Background: Voltage-dependent anion channel (VDAC), a channel protein, exists in the outer mitochondrial membrane of somatic cells and is involved in multiple physiological and pathophysiological processes.
Bianjiang Liu, Min Tang, Zhijian Han, Jie Li, Jiexiu Zhang, Pei Lu, Ninghong Song, Zengjun Wang, Changjun Yin, Wei Zhang   +9 more
doaj   +1 more source

Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs

Frontiers in Physiology, 2020
There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC).
Tatiana K. Rostovtseva, María Queralt-Martín, William M. Rosencrans, Sergey M. Bezrukov   +3 more
doaj   +1 more source