Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]
, 2013 Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Bhella, David +3 more
core +2 more sources
Markov chain Monte Carlo based analysis of post-translationally modified VDAC1 gating kinetics
Frontiers in Physiology, 2015 The voltage-dependent anion channel (VDAC) is the main conduit for permeation of solutes (including nucleotides and metabolites) of up to 5 kDa across the mitochondrial outer membrane (MOM). Recent studies suggest that VDAC activity is regulated via post-
Shivendra eTewari +5 more
doaj +1 more source
Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. [PDF]
PLoS ONE, 2011 The voltage-dependent anion channel (VDAC) forms the major pore in the outer mitochondrial membrane. Its high conducting open state features a moderate anion selectivity.
Eva-Maria Krammer +2 more
doaj +1 more source
Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]
, 2014 The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen +46 more
core +1 more source
Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs
Frontiers in Physiology, 2020 There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC).
Tatiana K. Rostovtseva +3 more
doaj +1 more source
Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. [PDF]
PLoS ONE, 2011 Tubulin was recently found to be a uniquely potent regulator of the voltage-dependent anion channel (VDAC), the most abundant channel of the mitochondrial outer membrane, which constitutes a major pathway for ATP/ADP and other metabolites across this ...
Kely L Sheldon +4 more
doaj +1 more source
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1 [PDF]
, 2017 Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell.
Abramson, Jeff +10 more
core +3 more sources
Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior [PDF]
, 2012 Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Anastasia Salisowski +8 more
core +8 more sources
Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility
Cellular Physiology and Biochemistry, 2014 Background: Voltage-dependent anion channel (VDAC), a channel protein, exists in the outer mitochondrial membrane of somatic cells and is involved in multiple physiological and pathophysiological processes.
Bianjiang Liu +9 more
doaj +1 more source
Frontiers in Physiology, 2021 Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, including ...
Hirohito Shimizu +11 more
doaj +1 more source