Results 31 to 40 of about 15,633 (213)
Voltage-dependent anion channels mediated apoptosis in refractory epilepsy
Open Medicine, 2020 The purpose of this study was to investigate the role of voltage-dependent anion channel (VDAC) in mitochondria-mediated apoptosis of neurons in refractory epilepsy. Western blot analyses were carried out to detect the changes in cytochrome C, caspase 9,
Zhao Yan +4 more
doaj +1 more source
Frontiers in Physiology, 2021 Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, including ...
Hirohito Shimizu +11 more
doaj +1 more source
Apoptosis: it's BAK to VDAC [PDF]
The EMBO Reports, 2009 The voltage‐dependent anion channel (VDAC) of the mitochondrial outer membrane (MOM; Mannella & Kinnally, 2008)—also known as mitochondrial porin—has long been implicated in regulating the mitochondrial response to certain cell death stimuli (Galluzzi & Kroemer, 2007).
openaire +2 more sources
Redox-dependent gating of VDAC by mitoNEET [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance This work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner.
Lipper, Colin H +8 more
openaire +4 more sources
VDAC closure increases calcium ion flux [PDF]
, 2007 VDAC is the major permeability pathway in the mitochondrial outer membrane and can control the flow of metabolites and ions. Therefore Ca2+ flux across the outer membrane occurs mainly through VDAC.
Tan, Wenzhi, Colombini, Marco
core +1 more source
Bid, but Not Bax, Regulates VDAC Channels [PDF]
Journal of Biological Chemistry, 2004 During apoptosis, cytochrome c is released from mitochondria into the cytosol, where it participates in caspase activation. Various and often conflicting mechanisms have been proposed to account for the increased permeability of the mitochondrial outer membrane that is responsible for this process.
Tatiana K, Rostovtseva +5 more
openaire +2 more sources
The role of glutamate release on voltage-dependent anion channels (VDAC)-mediated apoptosis in an eleven vessel occlusion model in rats. [PDF]
PLoS ONE, 2010 Voltage-dependent anion channel (VDAC) is the main protein in mitochondria-mediated apoptosis, and the modulation of VDAC may be induced by the excessive release of extracellular glutamate.
Eunkuk Park +7 more
doaj +1 more source
Biomolecules, 2021 It has become impossible to review all the existing literature on Voltage-Dependent Anion selective Channel (VDAC) in a single article. A real Renaissance of studies brings this protein to the center of decisive knowledge both for cell physiology and ...
Vito De Pinto
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VDAC-1 over-expression potentiates erastin’s cytotoxicity.
, 2016 Stably HT-29 cells or NCM460 colon epithelial cells expressing empty vector (pSuper-puro, “Vec”) or VDAC-1 cDNA (“VDAC-1”) were treated with designed erastin for applied time, VDAC-1 expression, cell survival and apoptosis were tested by Western blotting
Zhiyuan Zhou (350818) +5 more
core +1 more source
The intrinsically disordered N-terminus of the voltage-dependent anion channel.
PLoS Computational Biology, 2021 The voltage-dependent anion channel (VDAC) is a critical β-barrel membrane protein of the mitochondrial outer membrane, which regulates the transport of ions and ATP between mitochondria and the cytoplasm.
Jordane Preto, Isabelle Krimm
doaj +1 more source