Results 31 to 40 of about 14,744 (224)
Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs
Frontiers in Physiology, 2020 There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC).
Tatiana K. Rostovtseva +3 more
doaj +1 more source
Redox-dependent gating of VDAC by mitoNEET [PDF]
Proceedings of the National Academy of Sciences, 2019 SignificanceThis work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have implications for ferroptosis, apoptosis, and iron metabolism by linking VDAC function, mitoNEET, and ...
Lipper, Colin H +8 more
openaire +4 more sources
Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility
Cellular Physiology and Biochemistry, 2014 Background: Voltage-dependent anion channel (VDAC), a channel protein, exists in the outer mitochondrial membrane of somatic cells and is involved in multiple physiological and pathophysiological processes.
Bianjiang Liu +9 more
doaj +1 more source
Frontiers in Physiology, 2021 Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, including ...
Hirohito Shimizu +11 more
doaj +1 more source
Voltage-dependent anion channels mediated apoptosis in refractory epilepsy
Open Medicine, 2020 The purpose of this study was to investigate the role of voltage-dependent anion channel (VDAC) in mitochondria-mediated apoptosis of neurons in refractory epilepsy. Western blot analyses were carried out to detect the changes in cytochrome C, caspase 9,
Zhao Yan +4 more
doaj +1 more source
Apoptosis: it's BAK to VDAC [PDF]
EMBO reports, 2009 VDAC's role in Bak‐dependent mitochondrial outer membrane permeabilization (MOMP) is controversial. Gordon Shore makes sense of it all in light of an EMBO reports paper that shows that VDAC mediates mitochondrial recruitment of Bak, thereby controlling tBid‐induced MOMP.
openaire +2 more sources
The role of glutamate release on voltage-dependent anion channels (VDAC)-mediated apoptosis in an eleven vessel occlusion model in rats. [PDF]
PLoS ONE, 2010 Voltage-dependent anion channel (VDAC) is the main protein in mitochondria-mediated apoptosis, and the modulation of VDAC may be induced by the excessive release of extracellular glutamate.
Eunkuk Park +7 more
doaj +1 more source
Biomolecules, 2021 It has become impossible to review all the existing literature on Voltage-Dependent Anion selective Channel (VDAC) in a single article. A real Renaissance of studies brings this protein to the center of decisive knowledge both for cell physiology and ...
Vito De Pinto
doaj +1 more source
Bid, but Not Bax, Regulates VDAC Channels [PDF]
Journal of Biological Chemistry, 2004 During apoptosis, cytochrome c is released from mitochondria into the cytosol, where it participates in caspase activation. Various and often conflicting mechanisms have been proposed to account for the increased permeability of the mitochondrial outer membrane that is responsible for this process.
Tatiana K, Rostovtseva +5 more
openaire +2 more sources