Results 51 to 60 of about 14,744 (224)
Animal Models and Experimental Medicine, EarlyView.We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang +14 more
wiley +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
The Topology of VDAC as Probed by Biotin Modification [PDF]
Journal of Biological Chemistry, 1998 The outer membrane of mitochondria contains channels called VDAC (mitochondrial porin), which are formed by a single 30-kDa protein. Cysteine residues introduced by site-directed mutagenesis at sites throughout Neurospora crassa VDAC (naturally devoid of cysteine) were specifically biotinylated prior to reconstitution into planar phospholipid membranes.
J, Song +4 more
openaire +2 more sources
, 2016 Voltage-dependent anion channel (VDAC), the major channel of the mitochondrial outer membrane, serves as a principal pathway for ATP, ADP, and other respiratory substrates across this membrane.
Tatiana K. Rostovtseva (201233) +2 more
core +1 more source
PLoS ONE, 2011 Voltage-dependent anion channel (VDAC) is mainly located in the mitochondrial outer membrane and participates in many biological processes. In mammals, three VDAC subtypes (VDAC1, 2 and 3) have been identified.
Bianjiang Liu +3 more
doaj +1 more source
Reward history modulates perceptual load effects
Acta Psychologica, 2021 The reward history of a stimulus can yield strong attentional selection biases. Indeed, attentional capture can be triggered by previously rewarded items which are neither salient nor relevant for the ongoing task, even when selection is clearly counter ...
Jérémy Matias +4 more
doaj +1 more source
Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
PROTEOMICS, EarlyView.ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan +5 more
wiley +1 more source
Multicopy Suppressors of Phenotypes Resulting from the Absence of Yeast VDAC Encode a VDAC-like Protein [PDF]
Molecular and Cellular Biology, 1997 The permeability of the outer mitochondrial membrane to most metabolites is believed to be based in an outer membrane, channel-forming protein known as VDAC (voltage-dependent anion channel). Although multiple isoforms of VDAC have been identified in multicellular organisms, the yeast Saccharomyces cerevisiae has been thought to contain a single VDAC ...
E, Blachly-Dyson +4 more
openaire +2 more sources
Effect of pH on HK-VDAC binding.
, 2016 (A, B) Immunoblots (top) and quantified band intensities (bottom) of recombinant HK-1 (A) and HK-2 (B) co-immunoprecipitated with purified VDAC protein. Recombinant HK and purified VDAC protein were pre-incubated in pH 6.2 or 7.8 for 50 min.
Jin Won Park (2901029) +7 more
core +1 more source