Results 71 to 80 of about 15,633 (213)
Environmental Toxicology, EarlyView.ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim +4 more
wiley +1 more source
The Topology of VDAC as Probed by Biotin Modification [PDF]
Journal of Biological Chemistry, 1998 The outer membrane of mitochondria contains channels called VDAC (mitochondrial porin), which are formed by a single 30-kDa protein. Cysteine residues introduced by site-directed mutagenesis at sites throughout Neurospora crassa VDAC (naturally devoid of cysteine) were specifically biotinylated prior to reconstitution into planar phospholipid membranes.
J, Song +4 more
openaire +2 more sources
Pesquisa Veterinária Brasileira, 2012 A VDAC é uma porina presente na MME cuja função é crucial no metabolismo energético, sobrevivência e morte celular. A caracterização da VDAC torna-se importante para a compreensão das inter-relações da mitocôndria com os diferentes componentes ...
Phelipe Augusto Mariano Vitale +4 more
doaj
Membrane lipid composition modulates the organization of VDAC1, a mitochondrial gatekeeper
Communications BiologyVDACs, the most abundant proteins in the outer mitochondrial membrane (MOM), are crucial for mitochondrial physiology. VDAC regulate metabolite and ion exchange, modulate calcium homeostasis, and play roles in numerous cellular events such as apoptosis ...
Elodie Lafargue +8 more
doaj +1 more source
Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies
Brain Pathology, EarlyView.Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom +7 more
wiley +1 more source
Effect of pH on HK-VDAC binding.
, 2016 (A, B) Immunoblots (top) and quantified band intensities (bottom) of recombinant HK-1 (A) and HK-2 (B) co-immunoprecipitated with purified VDAC protein. Recombinant HK and purified VDAC protein were pre-incubated in pH 6.2 or 7.8 for 50 min.
Jin Won Park (2901029) +7 more
core +1 more source
VDAC structure, selectivity, and dynamics
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 VDAC channels exist in the mitochondrial outer membrane of all eukaryotic organisms. Of the different isoforms present in one organism, it seems that one of these is the canonical VDAC whose properties and 3D structure are highly conserved. The fundamental role of these channels is to control the flux of metabolites between the cytosol and ...
openaire +2 more sources
Acta Chimica SlovenicaNeurosteroids modulate the function of γ-aminobutyric acid type A (GABAA) receptors in the brain. We showed that GABAA receptors modulate neurosteroid interactions with VDAC. GABA enhanced [3H]6-AziP labeling of VDAC in a concentration-dependent manner.
Natalia Akentieva
doaj +1 more source
Reactive oxygen species, antioxidants and the regulation of plant development
The FEBS Journal, EarlyView.The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi +2 more
wiley +1 more source
Aims: Endoplasmic reticulum stress (ERS) with aberrant mitochondrial-ER contact (MERC), mitophagy, and apoptosis are interconnected determinants in neurodegenerative diseases.
Hanan S. El-Abhar (290828) +6 more
core +5 more sources