Results 71 to 80 of about 14,744 (224)

VDAC structure, selectivity, and dynamics

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
VDAC channels exist in the mitochondrial outer membrane of all eukaryotic organisms. Of the different isoforms present in one organism, it seems that one of these is the canonical VDAC whose properties and 3D structure are highly conserved. The fundamental role of these channels is to control the flux of metabolites between the cytosol and ...
openaire   +2 more sources

拟南芥AtGluRS相互作用蛋白质VDAC及其转基因植物表型分析

四川大学学报. 自然科学版, 2010
电压依赖性阴离子通道蛋白质(voltage-dependent anion channel,VDAC)是拟南芥谷氨酰tRNA合成酶(AtGluRS)相互作用的蛋白质.为了研究VDAC蛋白的功能和作用,通过构建VDAC稳定表达载体,农杆菌介导的方法转化拟南芥,筛选和鉴定出VDAC过量和抑制表达植株.研究结果证实VDAC的过量和抑制表达植株影响气孔关闭和种子萌发.VDAC的过量表达导致植株对ABA敏感,VDAC的抑制表达降低了植株对ABA的敏感性.推测VDAC蛋白可能参与ABA信号途径.
何菡, 严金平, 张建军, 刘震, 张皖蓉, 童仕波, 杨毅   +6 more
doaj  

Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. [PDF]

PLoS ONE, 2016
We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cancer cell
Haizhong Huo, Zhiyuan Zhou, Jian Qin, Wenyong Liu, Bing Wang, Yan Gu   +5 more
doaj   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

VDAC-dependent mitochondrial metabolism and cell proliferation differ between VDAC knockout and transient inhibition of VDAC expression

Biophysical Journal
68th Biophysical Society Annual ...
Santiago Valtierra, Florencia Ximena, Junco, Milagros, Ventura, Clara, Sanchez Gonzalez, Dativo, Ward, Richard, Garcia Arcos, Itsaso, Hartman, Jessica, Maldonado, Eduardo N.   +7 more
openaire   +2 more sources

Purificação e caracterização da VDAC de mitocôndrias corticais aviares: identificação de modificações pós-traducionais nas porinas neuronais murinas e aviares Purification and characterization of avian cortical mitochondrial VDAC: identification of post-translational modifications of rat and avian neuronal porins

Pesquisa Veterinária Brasileira, 2012
A VDAC é uma porina presente na MME cuja função é crucial no metabolismo energético, sobrevivência e morte celular. A caracterização da VDAC torna-se importante para a compreensão das inter-relações da mitocôndria com os diferentes componentes ...
Phelipe Augusto Mariano Vitale, Carla Rossini Crepaldi, Andréa Cristina Tesch, Ricardo de Albuquerque, Marcelo de Cerqueira César   +4 more
doaj  

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]

, 2013
Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Howell, Matthew, Hacker, Christian, Lucocq, John Milton, Lucocq, John, Bhella, David   +4 more
core   +1 more source

Purificação e caracterização da VDAC de mitocôndrias corticais aviares: identificação de modificações pós-traducionais nas porinas neuronais murinas e aviares

Pesquisa Veterinária Brasileira, 2012
A VDAC é uma porina presente na MME cuja função é crucial no metabolismo energético, sobrevivência e morte celular. A caracterização da VDAC torna-se importante para a compreensão das inter-relações da mitocôndria com os diferentes componentes ...
Phelipe Augusto Mariano Vitale, Carla Rossini Crepaldi, Andréa Cristina Tesch, Ricardo de Albuquerque, Marcelo de Cerqueira César   +4 more
doaj   +1 more source