Results 81 to 90 of about 15,633 (213)

Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases

The FEBS Journal, EarlyView.
Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger, Markus Daniel Gerber, Torsten Ochsenreiter, Christoph von Ballmoos, André Schneider   +4 more
wiley   +1 more source

Towards understanding of plant mitochondrial VDAC proteins: An overview of bean (Phaseolus) VDAC proteins

, 2017
As the main grain legume consumed worldwide, the common bean (Phaseolus vulgaris) is generally considered as a model for food legumes. The mitochondrial voltage-dependent anion-selective channel (VDAC) is the major transport pathway for inorganic ions ...
Kmita, Hanna, Saidani, Hayet, Leonetti, Marc, Grobys, Daria, Homblé, Fabrice   +4 more
core   +1 more source

Sites and functional consequence of VDAC–alkylphenol anesthetic interactions [PDF]

, 2014
General anesthetics have previously been shown to bind mitochondrial VDAC. Here, using a photoactive analog of the anesthetic propofol, we determined that alkylphenol anesthetics bind to Gly56 and Val184 on rat VDAC1.
Wong, David, Bu, Weiming, Weiser, Brian P., Eckenhoff, Roderic G.   +3 more
core   +1 more source

Role of the N-Terminal Moiety in VDAC Isoforms [PDF]

Biophysical Journal, 2010
VDAC or mitochondrial porin is the most abundant transmembrane protein in the mitochondrial outer membrane. Similarly to bacterial porins that are formed of a typical transmembrane β-barrel, the mitochondrial VDAC structure has been also found to form a β-barrel [1-3]. Interestingly the VDAC N-terminal 20 amino acids fold as an amphipathic α-helix [1-3]
DE PINTO, Vito Nicola, Reina S., Guarnera A., Tomasello F. M., GUARINO, FRANCESCA MARIA, MESSINA, Angela Anna   +5 more
openaire   +3 more sources

Single scores in the RT-based value-driven attentional capture paradigm have high reliability

Scientific Reports
Value-driven attentional capture (VDAC) involves involuntary attention shifts towards neutral stimuli previously associated with rewards. This phenomenon is pertinent for various neuropsychiatric conditions. This study aims to evaluate the reliability of
Chung-Yi Shih, Shuo-Heng Li, Ming-Chou Ho   +2 more
doaj   +1 more source

Purificação e caracterização da VDAC de mitocôndrias corticais aviares: identificação de modificações pós-traducionais nas porinas neuronais murinas e aviares

Pesquisa Veterinária Brasileira, 2012
A VDAC é uma porina presente na MME cuja função é crucial no metabolismo energético, sobrevivência e morte celular. A caracterização da VDAC torna-se importante para a compreensão das inter-relações da mitocôndria com os diferentes componentes ...
Phelipe Augusto Mariano Vitale, Carla Rossini Crepaldi, Andréa Cristina Tesch, Ricardo de Albuquerque, Marcelo de Cerqueira César   +4 more
doaj   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia

Biological Research, 2023
Background Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in mammals by three genes, VDAC1, 2 and 3, mostly ubiquitously expressed.
Xena Giada Pappalardo, Pierpaolo Risiglione, Federica Zinghirino, Angela Ostuni, Daniela Luciano, Faustino Bisaccia, Vito De Pinto, Francesca Guarino, Angela Messina   +8 more
doaj   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. [PDF]

PLoS ONE, 2014
BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway. We reported previously that mitochondrial localization of BNIP3 and translocation of EndoG from mitochondria to the nucleus are critical steps of the BNIP3 ...
Xiaosha Zhang, Xiuwu Bian, Jiming Kong
doaj   +1 more source