Results 101 to 110 of about 14,744 (224)
European Journal of Immunology, Volume 56, Issue 6, June 2026.LPS‐stimulated macrophages exhibit high glycolytic flux, with pyruvate preferentially converted to lactate even under normoglycemic conditions, limiting pyruvate availability for the tricarboxylic acid (TCA) cycle and reducing oxygen consumption rate (OCR).
Jila Nasirzade +8 more
wiley +1 more source
The VDAC channel: Molecular basis for selectivity
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 The voltage dependent anion-selective channel, VDAC, is the major permeability pathway by which molecules and ion cross the mitochondrial outer membrane. This pathway has evolved to optimize the flow of these substances and to control this flow by a gating process that is influenced by a variety of factors including transmembrane voltage.
openaire +2 more sources
Sites and functional consequence of VDAC–alkylphenol anesthetic interactions
, 2014 General anesthetics have previously been shown to bind mitochondrial VDAC. Here, using a photoactive analog of the anesthetic propofol, we determined that alkylphenol anesthetics bind to Gly56 and Val184 on rat VDAC1.
Wong, David +3 more
core +1 more source
Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.ABSTRACT Sepsis induces profound metabolic and mitochondrial dysfunction, contributing to multiple organ injury and mortality. Lipocalin‐2 (Lcn2), an acute‐phase protein, regulates iron homeostasis and oxidative stress, but its impact on mitochondrial resilience remains poorly understood.
Vinita Kushwaha +6 more
wiley +1 more source
Plasmalemmal VDAC controversies and maxi-anion channel puzzle
, 2012 The maxi-anion channel has been observed in many cell types from the very beginning of the patch-clamp era. The channel is highly conductive for chloride and thus can modulate the resting membrane potential and play a role in fluid secretion/absorption ...
Petr G. Merzlyak +3 more
core +1 more source
Advances in Bamboo ScienceMoso bamboo is an important fast-growing forest species. The rapid growth of its shoots and its ability to respond to environmental stresses, such as drought and low temperatures, directly influence its shoot yield and quality.
Zhen Yu +5 more
doaj +1 more source
VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis
Frontiers in Chemistry, 2018 Cancer and neurodegeneration are different classes of diseases that share the involvement of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called Warburg metabolism) and the suppression of apoptosis are key elements for the
Andrea Magrì +4 more
doaj +1 more source
To Include Plasmalemmal VDAC/Porin Pays
Journal of Biological Chemistry, 2012 The paper of Teijido et al. (1) will hopefully stimulate closer contacts between structure people and physiologists in the voltage-dependent anion channel (VDAC) community. It refines the VDAC model of Marco Colombini and also refers to the accessibility of the VDAC N-terminal end at mitochondria or the outer surface of the plasmalemma.
openaire +2 more sources
BNIP3 induces MPT by interacting with VDAC.
, 2014 A, BNIP3-induced MPT. Calcein release was presented as the percentage of calcein escaped from mitochondria during the 30-minute incubation ...
Jiming Kong (143823) +2 more
core +1 more source
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source