Results 121 to 130 of about 14,744 (224)
Computational Investigation of Cholesterol Binding Sites on Mitochondrial VDAC
, 2015 The mitochondrial voltage-dependent anion channel (VDAC) allows passage of ions and metabolites across the mitochondrial outer membrane. Cholesterol binds mammalian VDAC, and we investigated the effects of binding to human VDAC1 with atomistic molecular ...
Roderic G. Eckenhoff (1331799) +3 more
core +2 more sources
The Journal of Physiology, Volume 604, Issue 11, Page 4186-4207, 1 June 2026.Abstract figure legend Calciprotein particles (CPPs) are small calcium‐ and phosphate‐containing nanoaggregates associated with the development of vascular disease (CVD) in chronic kidney disease (CKD). Previously, we have shown that CPPs induce endothelial cell (EC) dysfunction, possibly contributing to CVD in CKD, but the underlying molecular ...
Lian Feenstra +9 more
wiley +1 more source
Physiological Reports, Volume 14, Issue 11, June 2026.Abstract Ischemia‐reperfusion injury (IRI) is a prevalent condition that predominantly afflicts hospitalized patients, inducing acute kidney injury (AKI). In recent years, complement 5 (C5) and its anaphylatoxin receptor C5aR1 have been implicated in driving kidney IRI and loss of function.
Madison McGraw +5 more
wiley +1 more source
VDAC and Mitochondrial Bioenergetics in Cancer Biology and Therapeutics
, 2022 The contribution of mitochondria to cancer cell metabolism is a continuously growing research field. Enhanced glycolysis and partial suppression of mitochondrial metabolism, reciprocally dependent in many tumors, characterize the pro-survival and ...
Heslop, Kareem Akeam
core
Aortic Segments‐Depending Hypertensive Remodeling Is Driven by Mitochondrial Fusion Dysfunction
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.A region‐specific protective function of OPA1 within the aortic wall under severe hypertensive stress. ABSTRACT OPA1 haploinsufficiency exacerbates severe hypertension‐induced aortic remodeling in a segment‐specific manner, revealing differential vulnerability between the suprarenal abdominal aorta (SRAA) and the descending thoracic aorta (DTA). In the
Alexis Richard +14 more
wiley +1 more source
Ceramides disrupt hexokinase HKI-VDAC complex assembly and modulate VDAC tilting
Abstract Ceramides bind voltage-dependent anion channels (VDACs) to promote mitochondrial apoptosis. However, the underlying mechanism is unclear. Ceramide binding relies on a charged, bilayer-facing glutamate that also controls complex formation between VDACs and pro-survival hexokinase HKI, suggesting that ceramides may exert their ...
Michael Timme +2 more
openaire +1 more source
The 3D structures of VDAC represent a native conformation
, 2010 The most abundant protein of the mitochondrial outer membrane is the voltage-dependent anion channel (VDAC), which facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by interactions with other proteins and ...
Gerhard Wagner +14 more
core +1 more source
New insight into hexokinase-VDAC interactions in a fungal system
, 2023 Hexokinase and VDAC are two critical proteins throughout fungi. Despite the considerable number of studies on VDAC-hexokinase interactions in animal systems, little research has been attempted looking at their interaction in fungal systems.
Dubyna, Jason
core
Does VDAC insert into membranes in random orientation?
, 2004 It is widely accepted that voltage-dependent anion-selective channel (VDAC) inserts into planar lipid bilayers in a random orientation. This is in contrast to the well-documented oriented insertion of various channel-forming proteins.
Marques, Edson J +3 more
core +1 more source
Scientific Reports, 2017 Mycobacterium avium subsp. hominissuis is associated with infection of immunocompromised individuals as well as patients with chronic lung disease. M. avium infects macrophages and actively interfere with the host killing machinery such as apoptosis and ...
Lia Danelishvili +4 more
doaj +1 more source